Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor β1 in obese Zucker rats by perindopril
Open accessAbstract
Objective: To determine whether angiotensin converting enzyme inhibition by perindopril can reduce cardiac transforming growth factor β1 (TGFβ1) and plasminogen activator inhibitor 1 (PAI-1) and therefore control collagen accumulation in an animal model with the metabolic syndrome such as the obese Zucker rat (OZR). Animals: Male OZR (group 1, n = 10); OZR treated with perindopril (group 2, n = 10); and lean Zucker rats (group 3, n = 10). Methods: During six months, group 2 received 3 mg/kg/day of perindopril orally and group 1 and group 3 were given a vehicle. Hearts were processed for pathology studies including immunohistochemical analysis with antibodies to PAI-1, TGFβ1, collagen type I, and collagen type III. Results: Group 2 had lower blood pressure (126.7 (2) v 148.6 (2.7) mm Hg, p < 0.01) than untreated OZR and had decreased cardiac PAI-1 (3.6 (0.4) v 13.5 (1.7)% of positive area/field, p < 0.01), TGFβ1 in myocytes (0.13 (0.1) v 9.14 (4.7)%/area, p < 0.01) and in interstitium (19.8 (6.8) v 178.9 (27.4) positive cells/area, p < 0.01), collagen I (3 (0.8) v 13.3 (1)%/area, p < 0.01), collagen III (5 (0.6) v 9.5 (0.9)%/area, p < 0.01), and collagen I to collagen III ratio (0.59 (0.13) v 1.40 (0.15) p < 0.01) compared with untreated OZR. Conclusion: These results suggest that perindopril reduces cardiac PAI-1 and TGFβ1 and ameliorates cardiac fibrosis in a rat model with multiple cardiovascular risk factors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased interstitial fibrosis occurs in the hearts of Zucker (fa/fa) rats and UCP-DTA mice.
“Increased interstitial fibrosis has been described in the hearts of Zucker (fa/fa) rats (350, 394) and in UCP-DTA mice (54).”
From Cardiac remodeling in obesity (2008) · cites this paper as [350]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hsu, S. M., Raine, L., & Fanger, H. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.4.6166661 · Cited by 14,248 · see citing works
Weber, K. T., & Brilla, C. G. (1991) · Circulation · doi:10.1161/01.cir.83.6.1849 · Cited by 2,035 · see citing works
He, J., Ogden, L. G., Bazzano, L. A., Vupputuri, S., Loria, C., & Whelton, P. K. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.7.996 · Cited by 1,172 · see citing works
Lisinopril-Mediated Regression of Myocardial Fibrosis in Patients With Hypertensive Heart Disease
Brilla, C. G., FUNCK, R. C., & Rupp, H. (2000) · Circulation · doi:10.1161/01.cir.102.12.1388 · Cited by 653 · see citing works
Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5971 · Cited by 604 · see citing works
Vaughan, D. E., Lazos, S. A., & Tong, K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117809 · Cited by 528 · see citing works
Petrov, V. V., Fagard, R. H., & Lijnen, P. J. (2002) · Hypertension · doi:10.1161/hy0202.103268 · Cited by 426 · see citing works
Wolf, G., Hamann, A., Han, D. C., Helmchen, U. M., Thaiss, F., Ziyadeh, F. N., & Stahl, R. A. K. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00626.x · Cited by 391 · see citing works
Mizushige, K., Yao, L., Noma, T., Kiyomoto, H., Yu, Y., Hosomi, N., Ohmori, K., & Matsuo, H. (2000) · Circulation · doi:10.1161/01.cir.101.8.899 · Cited by 326 · see citing works
Angiotensin II Has Multiple Profibrotic Effects in Human Cardiac Fibroblasts
Kawano, H., Yung, P. S., Kawano, Y., Starnes, V. A., Barr, M. L., Law, R. E., & Hsueh, W. A. (2000) · Circulation · doi:10.1161/01.cir.101.10.1130 · Cited by 312 · see citing works
The Zucker fatty rat as a genetic model of obesity and hypertension.
Kurtz, T. W., Morris, R. C., & Pershadsingh, H. A. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.896 · Cited by 261 · see citing works
Hormonal and cardiac effects of converting enzyme inhibition in rat myocardial infarction.
Michel, J., Lattion, A.-L., Salzmann, J. L., Cerol, M. D. L., Philippe, M., Camilleri, J.-P., & Corvol, P. L. (1988) · Circulation Research · doi:10.1161/01.res.62.4.641 · Cited by 222 · see citing works
Way, K. J., Isshiki, K., Suzuma, K., Yokota, T., Zvagelsky, D., Schöen, F. J., Sandusky, G. E., Pechous, P. A., Vlahos, C. J., Wakasaki, H., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2709 · Cited by 180 · see citing works
Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo
Nakamura, S., Nakamura, I., Ma, L., Vaughan, D. E., & Fogo, A. B. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00160.x · Cited by 178 · see citing works
van Leeuwen, R. T. J., Kol, A., Andreotti, F., Kluft, C., Maseri, A., & Sperti, G. (1994) · Circulation · doi:10.1161/01.cir.90.1.362 · Cited by 173 · see citing works
Han, D. C., Isono, M., Chen, S., Casaretto, A., Hong, S. W., Wolf, G., & Ziyadeh, F. N. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590041315.x · Cited by 151 · see citing works
Uehara, M., Kishikawa, H., Isami, S., Kisanuki, K., Ohkubo, Y., Miyamura, N., Miyata, T., Yano, T., & Shichiri, M. (1994) · Diabetologia · doi:10.1007/bf00398058 · Cited by 141 · see citing works
Enalapril Attenuates Oxidative Stress in Diabetic Rats
de Cavanagh, E. M. V., Inserra, F., Toblli, J. E., Stella, I., Fraga, C. G., & Ferder, L. (2001) · Hypertension · doi:10.1161/hy1101.092845 · Cited by 140 · see citing works
Self-citationEffects of captopril on glucose transport activity in skeletal muscle of obese Zucker rats
Henriksen, E. J., & Jacob, S. (1995) · Metabolism · doi:10.1016/0026-0495(95)90276-7 · Cited by 137 · see citing works
CAMPBELL, S., Janicki, J., & Weber, K. T. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(95)90359-3 · Cited by 136 · see citing works
Regulation of Myocardial Fibrillar Collagen by Angiotensin II. A Role in Hypertensive Heart Disease?
González, A. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2081 · Cited by 120 · see citing works
Cultured Myofibroblasts Generate Angiotensin Peptidesde Novo
Katwa, L. C., Campbell, S. E., Tyagi, S. C., Lee, S. J., Cicila, G. T., & Weber, K. T. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0376 · Cited by 116 · see citing works
Fogari, R., Zoppi, A., Lazzari, P., Preti, P. S., Mugellini, A., Corradi, L., & Lusardi, P. (1998) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199810000-00014 · Cited by 107 · see citing works
Higashiura, K., Ura, N., Takada, T., Li, Y., Torii, T., Togashi, N., Takada, M., Takizawa, H., & Shimamoto, K. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00174-0 · Cited by 95 · see citing works
Thrombospondin-1 Is the Key Activator of TGF-β1 in Human Mesangial Cells Exposed to High Glucose
Yevdokimova, N. Y., Wahab, N. A., & Mason, R. M. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v124703 · Cited by 92 · see citing works
Vuorinen-Markkola, H., & Yki‐Järvinen, H. (1995) · Metabolism · doi:10.1016/0026-0495(95)90293-7 · Cited by 85 · see citing works
Brilla, C. G. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00432-0 · Cited by 84 · see citing works
Kristian, R. E. T. T., WICKLMAYR, M., Dietze, G., & Häring, H.-U. (1996) · Diabetes · doi:10.2337/diab.45.1.s66 · Cited by 84 · see citing works
Experimental and genetic models of hypertension
de Jong, W., & Ganten, D. (1984) · Elsevier eBooks · Cited by 83 · see citing works
ACE Inhibition Versus Angiotensin Type 1 Receptor Antagonism
Brown, N. J., Kumar, S., Painter, C., & Vaughan, D. E. (2002) · Hypertension · doi:10.1161/01.hyp.0000040264.15961.48 · Cited by 81 · see citing works
Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats
Kolter, T., Uphues, I., & Eckel, J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e59 · Cited by 78 · see citing works
Zaman, A. K. M. T., Fujii, S., Sawa, H., Goto, D., Ishimori, N., Watano, K., Kaneko, T., Furumoto, T., Sugawara, T., Sakuma, I., et al. (2001) · Circulation · doi:10.1161/01.cir.103.25.3123 · Cited by 68 · see citing works
Samad, F., Pandey, M., Bell, P. A., & Loskutoff, D. J. (2000) · Molecular Medicine · doi:10.1007/bf03402048 · Cited by 64 · see citing works
Larghero, J., Leguay, T., Mourah, S., Madelaine, I., Taksin, A., Raffoux, E., Bastie, J.-N., Degos, L., Berthaud, P., Marolleau, J., et al. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00469-6 · Cited by 61 · see citing works
Effect of Glucose Tolerance Status on PAI‐1 Plasma Levels in Overweight and Obese Subjects
Pannacciulli, N., Mitrio, V. D., Marino, R., GIORGINO, R., & Pergola, G. D. (2002) · Obesity Research · doi:10.1038/oby.2002.98 · Cited by 56 · see citing works
Suzuki, M., Akimoto, K., & Hattori, Y. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02182-3 · Cited by 44 · see citing works
Amann, K., Simonaviciene, A., Medwedewa, T., Koch, A., Orth, S. R., Groß, M.-L., Haas, C. S., Kuhlmann, A., Linz, W., Schölkens, B. A., et al. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12122572 · Cited by 43 · see citing works
PAI-1 in human hypertension: relation to hypertensive groups
Srikumar, N., Brown, N. J., Hopkins, P. N., Jeunemaı̂tre, X., Hunt, S. C., Vaughan, D. E., & Williams, G. H. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)02952-7 · Cited by 40 · see citing works
Higaki, J., Aoki, M., Morishita, R., Kida, I., Taniyama, Y., Tomita, N., Yamamoto, K., Moriguchi, A., Kaneda, Y., & Ogihara, T. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.428 · Cited by 36 · see citing works
Huisamen, B., van Zyl, M., Keyser, A. T., & Lochner, A. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1017528402205 · Cited by 30 · see citing works
Cardiovascular protective role of a low-dose antihypertensive combination in obese Zucker rats
Toblli, J. E., DeRosa, G., Rivas, C., Cao, G., Piorno, P., Pagano, P., & Forcada, P. J. (2003) · Journal of Hypertension · doi:10.1097/00004872-200303000-00028 · Cited by 29 · see citing works
Self-citationDiabetes and Hypertension: Experimental Models for Pharmacological Studies
van Zwieten, P. A. (1999) · Clinical and Experimental Hypertension · doi:10.3109/10641969909068644 · Cited by 27 · see citing works
Solano, M. P., PERRY, A. C., Wang, X., Ross, R., & Goldberg, R. B. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802192 · Cited by 26 · see citing works
Perindopril Reverses Myocyte Remodeling in the Hypertensive Heart
Onodera, T., OKAZAKI, F., Miyazaki, H., Minami, S., Ito, T., Seki, S., Taniguchi, M., TANIGUCHI, I., & Mochizuki, S. (2002) · Hypertension Research · doi:10.1291/hypres.25.85 · Cited by 16 · see citing works
Bertram, D., Blanc-Brunat, N., Sassard, J., & Lo, M. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00620.2001 · Cited by 12 · see citing works
Goto, D., Fujii, S., Kaneko, T., Furumoto, T., Sugawara, T., Zaman, A. K. M. T., Imagawa, S., Dong, J., Nakai, Y., Mishima, T., et al. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00162-x · Cited by 7 · see citing works
Dunstan, H. J., Ta, B., Bertram, J. F., Johnston, C. I., & Black, M. J. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03793.x · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Vaughan DE, Lazos SA, Tong K. Angiotensin II regulates the expression of plasminogen activator-1 in cultured endothelial cells. J Clin Invest 1995;95:995-1001.
Cited by
Sorted by citations
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Russo, I., & Frangogiannis, N. G. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.011 · Cited by 481 · see citing works
Cavalera, M., Wang, J., & Frangogiannis, N. G. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.001 · Cited by 269 · see citing works
Cardiovascular effects of leptin
Sweeney, G. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.224 · Cited by 184 · see citing works
The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms
Salvatore, T., Pafundi, P. C., Galiero, R., Albanese, G., Di Martino, A., Caturano, A., Vetrano, E., Rinaldi, L., & Sasso, F. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.695792 · Cited by 165 · see citing works
The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights
Bohne, L. J., Johnson, D., Rose, R. A., Wilton, S. B., & Gillis, A. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00135 · Cited by 153 · see citing works
Huo, J., Feng, Q., Pan, S., Fu, W.-J., Liu, Z., & Liu, Z. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01553-4 · Cited by 148 · see citing works
Tuleta, I., & Frangogiannis, N. G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113904 · Cited by 137 · see citing works
Impact of obesity on cardiac metabolism, fibrosis, and function
Mahajan, R., Lau, D. H., & Sanders, P. (2014) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.09.005 · Cited by 109 · see citing works
ACE Inhibition and AT1 Receptor Blockade Prevent Fatty Liver and Fibrosis in Obese Zucker Rats
Toblli, J. E., Muñoz, M. C., Cao, G., Mella, J. M., Pereyra, L., & Mastaï, R. (2008) · Obesity · doi:10.1038/oby.2007.114 · Cited by 100 · see citing works
Self-citationPathophysiological Fundamentals of Diabetic Cardiomyopathy
Hu, X., Bai, T., Xu, Z., Liu, Q., Zheng, Y., & Cai, L. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160021 · Cited by 103 · see citing works
Pan, K., Hsu, Y., Chang, S., Chung, C., & Lin, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108604 · Cited by 80 · see citing works
Extracellular matrix remodelling in obesity and metabolic disorders
Musale, V., Wasserman, D. H., & Kang, L. (2023) · Life Metabolism · doi:10.1093/lifemeta/load021 · Cited by 76 · see citing works
Diabetes and Myocardial Fibrosis
Salvador, D., Gamba, M., González-Jaramillo, N., González-Jaramillo, V., Raguindin, P. F., Minder, B., Gräni, C., Wilhelm, M., Stettler, C., Doria, A., et al. (2022) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2021.12.008 · Cited by 64 · see citing works
Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus
Toblli, J. E., Ferrini, M. G., Cao, G., Vernet, D. A., Angerosa, M., & González-Cadavid, N. F. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp103 · Cited by 60 · see citing works
Self-citationNettore, I. C., Rocca, C., Mancino, G., Albano, L., Amelio, D., Grande, F., Puoci, F., Pasqua, T., Desiderio, S., Mazza, R., et al. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.03.019 · Cited by 59 · see citing works
de Oliveira-Junior, S. A., Martinez, P. F., Guizoni, D. M., Campos, D. H. S., Fernandes, T., de Oliveira, E. M., Okoshi, M. P., Okoshi, K., Padovani, C. R., & Cicogna, A. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086447 · Cited by 55 · see citing works
MicroRNA-410-5p exacerbates high-fat diet-induced cardiac remodeling in mice in an endocrine fashion
Zou, T., Zhu, M. J., Ma, Y., Xiao, F., Yu, X. M., Li, X., Ma, L., Yang, J., & Dong, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-26646-4 · Cited by 47 · see citing works
Wang, T. J., Larson, M. G., Benjamin, E. J., Siwik, D. A., Safa, R., Guo, C., Corey, D., Sundström, J., Sawyer, D. B., Colucci, W. S., et al. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.04.006 · Cited by 41 · see citing works
Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats
Burlá, A. K., Lobato, N. S., Fortes, Z. B., Oigman, W., & Neves, M. F. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.09.012 · Cited by 34 · see citing works
Influence of Term of Exposure to High-Fat Diet-Induced Obesity on Myocardial Collagen Type I and III
da Silva, D. C. T., Lima‐Leopoldo, A. P., Leopoldo, A. S., de Campos, D. H. S., do Nascimento, A. F., de Oliveira-Junior, S. A., Padovani, C. R., & Cicogna, A. C. (2013) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20130232 · Cited by 26 · see citing works
Panza, S. B., Vargas, R., Balbo, S. L., Bonfleur, M. L., Granzotto, D. C. T., Sant’Ana, D. D. M. G., & de Melo, G. D. A. N. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119350 · Cited by 20 · see citing works
Galis, P., Bartosova, L., Farkašová, V., Barteková, M., Ferenczyová, K., & Rajtík, T. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1451100 · Cited by 18 · see citing works
Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling
Liang, Y., Lang, A. L., Zhang, J., Chen, J., Wang, K., Chen, L., Beier, J. I., Qian, Y., & Cai, L. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00043 · Cited by 17 · see citing works
Toblli, J. E., Cao, G., Casabé, A. R., & Bechara, A. J. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00597.x · Cited by 16 · see citing works
Self-citationThe emerging role of leptin in obesity-associated cardiac fibrosis: evidence and mechanism
Mao, Y., Zhao, K., Li, P., & Sheng, Y. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04562-6 · Cited by 14 · see citing works
Toblli, J. E., Cao, G., & Angerosa, M. (2015) · BioMetals · doi:10.1007/s10534-015-9822-3 · Cited by 14 · see citing works
Self-citationPathophysiological Fundamentals of Diabetic Cardiomyopathy
Hu, X., Bai, T., Xu, Z., Liu, Q., Zheng, Y., & Cai, L. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00752.x · Cited by 11 · see citing works
The effects of a high-fat diet on left ventricular fibrosis
Czarzasta, K., Koperski, Ł., Fus, Ł., Wojno, O., Górnicka, B., & Cudnoch‐Jędrzejewska, A. (2018) · Kardiologia Polska · doi:10.5603/kp.2018.0080 · Cited by 7 · see citing works
Unamuno, X., Frühbeck, G., & Catalán, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65163-2 · Cited by 7 · see citing works
The role of high fat diet in the regulation of MAP kinases activity in left ventricular fibrosis
Czarzasta, K., Koperski, Ł., Segiet, A., Janiszewski, M., Kuch, M., Górnicka, B., & Cudnoch‐Jędrzejewska, A. (2019) · Acta Histochemica · doi:10.1016/j.acthis.2019.01.010 · Cited by 6 · see citing works
Toblli, J. E., Grana, D. R., Cao, G., & Milei, J. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.09.004 · Cited by 6 · see citing works
Self-citationConnolly, K., Batacan, R. B., Jackson, D., Vella, R. K., & Fenning, A. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121291 · Cited by 5 · see citing works
Brilliant, J., Yadav, R., Akhtar, T., Calkins, H. G., Trayanova, N. A., & SPRAGG, D. D. (2023) · Current Cardiology Reviews · doi:10.2174/1573403x19666230331103153 · Cited by 5 · see citing works
Karthik, D., Elumalai, A., Viswanathan, P., & Anuradha, C. V. (2012) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(12)60292-8 · Cited by 4 · see citing works
Salam, T. S. A., El‐Bakly, W. M., Badawy, A., Hasanin, A. H., & Raafat, M. H. (2020) · Ain Shams Journal of Forensic Medicine and Clinical Toxicology · doi:10.21608/ajfm.2020.68226 · Cited by 3 · see citing works
He, Q., Lai, Z., Zhai, Z., Zou, B., Shi, Y., & Feng, C. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1501735 · Cited by 2 · see citing works
Barretti, D. L. M., do Carmo, E. C., Rosa, K. T., Irigoyen, M. C., & de Oliveira, E. M. (2011) · Revista Brasileira de Educação Física e Esporte · doi:10.1590/s1807-55092011000400005 · Cited by 1 · see citing works
Diabetes mellitus and atrial fibrillation—Untying the Gordian Knot
Domek, M., Javed, S., Gumprecht, J. J., & Lip, G. Y. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817428-9.00004-8 · Cited by 1 · see citing works
Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
Bairwa, S. C. (2014) · Scholarship@Western (Western University)
Influência do exercício físico na remodelação cardíaca induzida pelo ácido retinóico
Claro, R. F. T. (2015) · Americanae (AECID Library)
Obesity and Cardiac Dysfunction
Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14
Cristina, D., da Silva, T., Lima‐Leopoldo, A. P., Leopoldo, A. S., Henrique, D., do Nascimento, A. F., de Oliveira-Junior, S. A., & Padovani, C. R. (2013)
Renin Angiotensin System in the Pathophysiology of Diabetic Cardiomyopathy in Type 2 Diabetes
Gomes, K. P., Jadli, A. S., & Patel, V. B. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-14952-8_15
Al-U'datt, D. G. F., Mahmoud, D., Tranchant, C. C., Rawashdeh, S., Tashtush, A. A., Almoghrabi, K. S., & Alfwaress, M. F. (2025) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2025.11.009
Obesity-Associated Cardiac Fibrosis: Mechanisms and Emerging Therapeutic Targets
Zhou, D., Tan, Y., Zhao, J., Wang, S., Wang, Z., Bai, M., Niu, X., & Zhang, Z. (2026) · Vascular Health and Risk Management · doi:10.2147/vhrm.s567568
- Authors
- Toblli, J. E., Cao, G., DeRosa, G., & Forcada, P.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Toblli, J E
- ORCID
- Toblli, J E
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2004-12-16
- Volume
- 91
- Issue
- 1
- Pages
- 80-86
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- PMC
- PMC1768649
- OpenAlex
- W2057466013
- Cited by
- 47
- References
- 47
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- perindopril, plasminogen activator inhibitor-1, TGF-β1, myocardial fibrosis, collagen deposition, angiotensin-converting enzyme inhibition, Zucker fatty rats, metabolic syndrome, hypertension
- MeSH terms
- Angiotensin-Converting Enzyme Inhibitors, Animals, Blood Pressure, Collagen, Disease Models, Animal, Male, Myocardium, Obesity, Organ Size, Rats, Zucker, Transforming Growth Factor beta, Plasminogen Activator Inhibitor 1, Perindopril, Metabolic Syndrome, Rats, Transforming Growth Factor beta1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
