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Cited by 204Heart Failure Treatment and ManagementAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Circulating adiponectin concentrations in patients with congestive heart failure

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George, J, Patal, S, Wexler, D, Sharabi, Y, Peleg, E, Kamari, Y, Grossman, E, Sheps, D +2 more·2006·Heart
DOI 10.1136/hrt.2005.083345PMC PMC1861042
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Abstract

Objectives: To determine concentrations of adiponectin and its predictive value on outcome in a cohort of patients with congestive heart failure (CHF). Methods: Serum and clinical data were obtained for outpatients with clinically controlled CHF (n = 175). Serum concentrations of adiponectin, C reactive protein, N-terminal pro-brain natriuretic peptide (NT-proBNP), interleukin (IL) -1β, IL-6, IL-8, IL-10, IL-12, tumour necrosis factor α and CD-40 ligand were determined. The association of adiponectin with the clinical severity of CHF was sought as well as the predictive value of this adipokine on mortality, CHF hospitalisations or the occurrence of each of these end points. Results: Concentrations of adiponectin were significantly increased in patients with CHF. Patients with higher New York Heart Association class had significantly higher serum concentrations of adiponectin. Adiponectin serum concentrations were lower in patients with diabetes and CHF as well as in patients with ischaemic cardiomyopathy. Serum adiponectin concentration was positively associated with age and NT-proBNP but was negatively correlated with C reactive protein concentrations. Serum adiponectin above the 75th centile was found to be an independent predictor of total mortality, CHF hospitalisations or a composite of these end points over a two-year prospective follow up. Conclusion: Adiponectin is increased in CHF patients and predicts mortality and morbidity.

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  • Clinical studies have established correlations between plasma adiponectin levels and various aspects and severity of heart failure.

    “First, an important pathophysiological contribution was suggested by the recent explosion in the number of clinical studies that have established correlations between plasma adiponectin levels and various aspects and severity of heart failure (107, 113, 143, 166, 172, 183, 198, 209, 251, 275, 282, 286, 303, 312, 366).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [113]

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Authors
George, J., Patal, S., Wexler, D., Sharabi, Y., Peleg, E., Kamari, Y., Grossman, E., Sheps, D., Keren, G., & Roth, A.
Affiliations
  • Tel Aviv Sourasky Medical Center (IL)
  • Tel Aviv University (IL)
  • Sheba Medical Center (IL)
Corresponding author
George, J
ORCID
George, J
Venue
Heart
Publisher
BMJ
Published
2006-04-18
Volume
92
Issue
10
Pages
1420-1424
ISSN
  • 1355-6037 (ISSN-L)
  • 1468-201X
DOI
10.1136/hrt.2005.083345
PMC
PMC1861042
OpenAlex
W2110325808
Cited by
204
References
18
Citations by year
2025: 5 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 4 · 2017: 8 · 2016: 10 · 2015: 7 · 2014: 6 · 2013: 19 · 2012: 17
FWCI
13.76
Type
journal article
Language
en
Open access
Locations
  • Heart (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
adiponectin, congestive heart failure, circulating adipokines, mortality prediction, heart failure hospitalization, NT-proBNP, C-reactive protein, inflammation, NYHA functional class, ischemic cardiomyopathy, diabetes mellitus, prognostic factors
MeSH terms
Aged, C-Reactive Protein, Female, Heart Failure, Humans, Male, Cohort Studies, Biomarkers, Cytokines, Disease-Free Survival, Adiponectin

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