Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex

Cnop, M.; Havel, P. J.; Utzschneider, K. M.; Carr, D. B.; Sinha, M. K.; Boyko, E. J.; Retzlaff, B. M.; Knopp, R. H.; Brunzell, J. D.; Kahn, S. E.

doi:10.1007/s00125-003-1074-z

Cited by 1,483Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityAdipose Tissue and Metabolism

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex

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Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H. +2 more·2003·Diabetologia

DOI 10.1007/s00125-003-1074-z

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Abstract

Aims/hypothesis Increased intra-abdominal fat is associated with insulin resistance and an atherogenic lipoprotein profile. Circulating concentrations of adiponectin, an adipocyte-derived protein, are decreased with insulin resistance. We investigated the relationships between adiponectin and leptin, body fat distribution, insulin sensitivity and lipoproteins.Methods We measured plasma adiponectin, leptin and lipid concentrations, intra-abdominal and subcutaneous fat areas by CT scan, and insulin sensitivity index (S(I)) in 182 subjects (76 M/106F).Results Adiponectin concentrations were higher in women than in men (7.4+/-2.9 vs 5.4+/-2.3 micro g/ml, p<0.0001) as were leptin concentrations (19.1+/-13.7 vs 6.9+/-5.1 ng/ml, p<0.0001). Women were more insulin sensitive (S(I): 6.8+/-3.9 vs 5.9+/-4.4 x 10(-5) min(-1)/(pmol/l), p<0.01) and had more subcutaneous (240+/-133 vs 187+/-90 cm(2), p<0.01), but less intra-abdominal fat (82+/-57 vs 124+/-68 cm(2), p<0.0001). By simple regression, adiponectin was positively correlated with age ( r=0.227, p<0.01) and S(I) ( r=0.375, p<0.0001), and negatively correlated with BMI ( r=-0.333, p<0.0001), subcutaneous ( r=-0.168, p<0.05) and intra-abdominal fat ( r=-0.35, p<0.0001). Adiponectin was negatively correlated with triglycerides ( r=-0.281, p<0.001) and positively correlated with HDL cholesterol ( r=0.605, p<0.0001) and Rf, a measure of LDL particle buoyancy ( r=0.474, p<0.0001). By multiple regression analysis, adiponectin was related to age ( p<0.0001), sex ( p<0.005) and intra-abdominal fat ( p<0.01). S(I) was related to intra-abdominal fat ( p<0.0001) and adiponectin ( p<0.0005). Both intra-abdominal fat and adiponectin contributed independently to triglycerides, HDL cholesterol and Rf.Conclusion/interpretation These data suggest that adiponectin concentrations are determined by intra-abdominal fat mass, with additional independent effects of age and sex. Adiponectin could link intra-abdominal fat with insulin resistance and an atherogenic lipoprotein profile.

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Several molecules secreted by adipose tissue correlate directly with adipose tissue mass and can act as biological markers of inflammation and metabolic dysfunction.
“These include several molecules that correlate directly with adipose tissue mass and can act as biological markers of inflammation and metabolic dysfunction [[32], [33], [34], [35]].”
From Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism (2024) · cites this paper as [34]

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Authors: Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D., & Kahn, S. E.
Affiliations: University of Washington (US)
University of California, Davis (US)
ORCID: Cnop, M.
Havel, P. J.
Utzschneider, K. M.
Boyko, E. J.
Brunzell, J. D.
Kahn, S. E.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2003-04
Volume: 46
Issue: 4
Pages: 459-469
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-003-1074-z
OpenAlex: W1570155932
Cited by: 1,483
References: 73
Citations by year: 2026: 18 · 2025: 36 · 2024: 38 · 2023: 51 · 2022: 49 · 2021: 53 · 2020: 71 · 2019: 60 · 2018: 45 · 2017: 62 · 2016: 48 · 2015: 75 · 2014: 84 · 2013: 72 · 2012: 83
FWCI: 55.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: American Diabetes Association
U.S. Department of Agriculture
U.S. Department of Veterans Affairs (DK-17047)
Belgian American Educational Foundation
University of Washington (DK17047, DK-35816)
National Institutes of Health (RR-37, DK-35747, DK35816)
National Heart, Lung, and Blood Institute (P01HL030086, HL3-0086)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-35816, DK-59417, DK 02456, K24DK002654, DK -35747, DK 02654, DK-17047, P30DK035816, P30DK017047, P30DK035747)
National Center for Research Resources (RR 37)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: adiponectin, leptin, body fat distribution, insulin sensitivity, serum lipoproteins, intra-abdominal fat, subcutaneous adipose tissue, sex differences, age effects, HDL cholesterol, triglycerides, body mass index, insulin resistance, atherogenic lipoprotein profile, adipokines, adipocytes, adipose tissue
MeSH terms: Adipose Tissue, Adult, Aged, Aging, Body Composition, Demography, Female, Humans, Insulin Resistance, Lipoproteins, Male, Middle Aged, Phenotype, Proteins, Sex Characteristics, Cohort Studies, Leptin, Abdominal Wall, Intercellular Signaling Peptides and Proteins, Adiponectin

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Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex

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