The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Exercise induced vasodepressor syncope
Open accessAbstract
Five cases of exercise induced pure vasodepressor syncope in patients without significant structural heart disease are reported. Hypotension and symptoms of syncope or pre-syncope were induced by treadmill exercise testing and in each case limited exercise performance. Evidence of inappropriate peripheral vasodilation, probably as a consequence of ventricular mechanoreceptor stimulation, was shown in all five patients. Head up tilt testing resulted in hypotension in four patients and isoprenaline infusion in the supine position resulted in hypotension in the fifth. These patients had a new condition of exercise induced neurally mediated (vasodepressor) syncope without appreciable structural cardiac abnormalities.
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Syncope occurring after exercise is almost invariably due to a reflex mechanism.
“whereas syncope occurring after exercise is almost invariably due to a reflex mechanism. 250-252”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [250]
The Discussion describes exercise-induced neurally mediated (vasovagal) syncope and distinguishes the authors’ cases, whose symptoms began during exercise, from symptoms occurring afterward. The Abstract also notes reports of bradycardia and asystole after exercise in patients with normal hearts. These passages support a reflex mechanism as a possibility, but do not establish that post-exercise syncope is almost invariably reflex-mediated. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSyncope occurring during exercise is likely due to cardiac causes.
“Indeed, syncope occurring during exercise is likely due to cardiac causes (even though some case reports have shown that it might be a manifestation of an exaggerated reflex vasodilatation)”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [250]
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Cites
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Self-citationTILTING TOWARDS A DIAGNOSIS IN RECURRENT UNEXPLAINED SYNCOPE
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Cardiac asystole: A manifestation of neurally mediated hypotension-bradycardia
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2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951
Report of the NASPE Policy Conference on Arrhythmias and the Athlete
ESTES, N. A. M., LINK, M. S., CANNOM, D., NACCARELLI, G. V., PRYSTOWSKY, E. N., MARON, B. J., & OLSHANSKY, B. (2001) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2001.01208.x · Cited by 95
Failure of reflex venoconstriction during exercise in patients with vasovagal syncope
Thomson, H. L., Atherton, J. J., Khafagi, F. A., & Frenneaux, M. P. (1996) · Circulation · doi:10.1161/01.cir.93.5.953 · Cited by 76
Self-citationSHELDON, R., HERSI, A., RITCHIE, D., KOSHMAN, M., & ROSE, S. (2010) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2010.01835.x · Cited by 61
Metadata
- Authors
- Sneddon, J. F., Scalia, G., Ward, D. E., McKenna, W. J., Camm, A. J., & Frenneaux, M. P.
- Affiliations
- St George's Hospital (GB)
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1994-06-01
- Volume
- 71
- Issue
- 6
- Pages
- 554-557
- ISSN
- 1355-6037 (ISSN-L)
- PMC
- PMC1025452
- OpenAlex
- W2110652143
- Cited by
- 61
- References
- 24
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 5 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- exercise-induced syncope, vasodepressor syncope, neurally mediated syncope, hypotension, peripheral vasodilation, head-up tilt, treadmill exercise testing
- MeSH terms
- Adolescent, Adult, Aged, Cardiac Output, Disopyramide, Exercise Test, Female, Heart Rate, Humans, Hypotension, Hypotension, Orthostatic, Male, Metoprolol, Syncope, Vascular Resistance, Exercise
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