Birth weight, weight at one year, and left ventricular mass in adult life.
Open accessAbstract
OBJECTIVE: To examine how fetal and infant growth are related to left ventricular mass in adult life. DESIGN: A follow up study of men born during 1920-30 whose birth weights and weights at 1 year were recorded. SETTING: Hertfordshire, England. SUBJECTS: 290 men born and still living in East Hertfordshire, England. MAIN OUTCOME MEASURE: Left ventricular mass calculated from measurements of interventricular septal thickness and left ventricular posterior wall thickness and left ventricular internal diameter at end diastole measured by M mode echocardiography. RESULTS: Left ventricular mass was highest in men with the lowest weight at 1 year and fell with increasing weight at 1 year (r = 0.18, P = 0.01). Left ventricular mass was not related to birth weight. The relation with weight at 1 year was independent of factors in adult life known to influence left ventricular mass, including body size, systolic blood pressure, and age. The enlarged left ventricular mass associated with reduced growth in infancy was concentric, affecting both the interventricular septum and the left ventricular posterior wall. Concentric left ventricular hypertrophy is known to be associated with increased death rates from coronary artery disease. CONCLUSION: Low weight at 1 year is associated with concentric enlargement of the left ventricle in adult life. This is consistent with a previous finding of higher mortality from cardiovascular disease in men of low weight at 1 year, and provides further evidence that cardiovascular disease may be partly programmed in early life. The left ventricular enlargement may be a long term result of haemodynamic changes in utero or of persisting changes in growth factor concentrations.
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In a separate study of adult men, concentric enlargement of the left ventricle, a known predictor of coronary heart disease, was associated with low weight at 1 year.
“In a separate study of adult men, concentric enlargement of the left ventricle, a known predictor of coronary heart disease, was found to be associated with low weight at 1 year (548).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [548]
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In utero programming of chronic disease
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- Authors
- Vijayakumar, M., Fall, C. H., Osmond, C., & Barker, D. J.
- Affiliations
- Southampton General Hospital (GB)
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1995-04-01
- Volume
- 73
- Issue
- 4
- Pages
- 363-367
- ISSN
- 1355-6037 (ISSN-L)
- PMC
- PMC483831
- OpenAlex
- W2001012384
- Cited by
- 105
- References
- 23
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- birth weight, infant weight, left ventricular mass, left ventricular hypertrophy, fetal growth, infant growth, cardiovascular risk, interventricular septum thickness, left ventricular posterior wall thickness, coronary artery disease mortality
- MeSH terms
- Aged, Birth Weight, Body Weight, Cardiovascular Diseases, Echocardiography, Follow-Up Studies, Heart, Heart Ventricles, Humans, Male, Risk Factors
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