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Autoimmunity to alpha myosin in a subset of patients with idiopathic dilated cardiomyopathy.
Open accessAbstract
OBJECTIVE: To use an enzyme linked immunoassay (ELISA) technique to assess frequency and disease specificity of anti-alpha-myosin antibodies in patients with dilated cardiomyopathy and their relatives. METHODS: Evaluation was performed on sera (dilution 1/320) from 123 consecutive patients with dilated cardiomyopathy (WHO criteria) (age 42 (SD 14) years), 252 of their relatives (35 (17) years), 203 healthy controls (45 (16) years), and 92 patients with ischaemic heart disease (63 (11) years). RESULTS: Abnormal antibody levels were commoner in patients with dilated cardiomyopathy (25, 20%) than in ischaemic heart disease (4, 4%), or normal controls (4, 2%, P = 0.001). Forty one (16%) of the relatives had abnormal results compared to the controls (4, 2%, P < 0.001) and antibodies were detected in 20 (38%) of pedigrees. Relatives from non-familial kindreds had higher antibody levels than those with familial disease (P << 0.001), and higher antibody levels were identified in 53 relatives of probands who had abnormal results compared to 116 relatives for whom the proband had a normal result (0.37 (SEM 0.02) v 0.22 (0.01); P < 0.001). CONCLUSIONS: The finding of anti-alpha-myosin antibodies in 20% of patients with dilated cardiomyopathy, in 16% of their asymptomatic relatives, and in 38% of families (particularly those with non-familial disease and where proband also had an abnormal result) provides additional evidence for autoimmunity against alpha myosin in a subset of patients.
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α-MyHC is a target of both autoreactive T cells and autoantibodies in myocarditis.
“Early investigations identified α -MyHC as a target of both autoreactive T cells and autoantibodies in the context of myocarditis.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [48]
The Results and Discussion report anti-α-myosin antibodies in a subset of patients with dilated cardiomyopathy; the References also cite a study of cardiac-myosin autoantibodies in mice susceptible to myocarditis. This paper does not report autoreactive T cells targeting α-myosin in myocarditis, so it supports only part of the attributed claim. Page numbers were not provided for these passages. (LLM, conf=0.86)
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Research works printed but not linked: 24
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Cited by
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Metadata
- Authors
- Goldman, J. H., Keeling, P. J., Warraich, R. S., Baig, M. K., Redwood, S. R., Dalla Libera, L., Sanderson, J. E., Caforio, A. L., & McKenna, W. J.
- Affiliations
- St George's Hospital (GB)
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1995-12-01
- Volume
- 74
- Issue
- 6
- Pages
- 598-603
- ISSN
- 1355-6037 (ISSN-L)
- PMC
- PMC484112
- OpenAlex
- W2009540687
- Cited by
- 62
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Funders
- British Heart Foundation
- Regione del Veneto
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Rheumatology › Inflammatory Myopathies and Dermatomyositis
- Keywords
- idiopathic dilated cardiomyopathy, autoimmunity, familial dilated cardiomyopathy, asymptomatic relatives, ischemic heart disease, disease specificity
- MeSH terms
- Adult, Autoantibodies, Cardiomyopathy, Dilated, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Myosins, Sensitivity and Specificity, Prevalence, Myocardial Ischemia
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