The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cancer stem cells in colorectal cancer: a review
Abstract
Colorectal cancer (CRC) is the second most common cancer in women and the third most common in men. Adenocarcinoma accounts for 90% of CRC cases. There has been accumulating evidence in support of the cancer stem cell (CSC) concept of cancer which proposes that CSCs are central in the initiation of cancer. CSCs have been the focus of study in a range of cancers, including CRC. This has led to the identification and understanding of genes involved in the induction and maintenance of pluripotency of stem cells, and markers for CSCs, including those investigated specifically in CRC. Knowledge of the expression pattern of CSCs in CRC has been increasing in recent years, revealing a heterogeneous population of cells within CRC ranging from pluripotent to differentiated cells, with overlapping and sometimes unique combinations of markers. This review summarises current literature on the understanding of CSCs in CRC, including evidence of the presence of CSC subpopulations, and the stem cell markers currently used to identify and localise these CSC subpopulations. Future research into this field may lead to improved methods for early detection of CRC, novel therapy and monitoring of treatment for CRC and other cancer types.
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Cites
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Cited by
Gut bacteria signaling to mitochondria in intestinal inflammation and cancer
Jackson, D. N., & Theiss, A. L. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1592421 · Cited by 312
Curcumin and colorectal cancer: An update and current perspective on this natural medicine
Weng, W., & Goel, A. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.02.011 · Cited by 287
López de Andrés, J., Griñán-Lisón, C., Jiménez, G., & Marchal, J. A. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00966-3 · Cited by 207
The Impact of Cancer Stem Cells in Colorectal Cancer
Radu, P., Zurzu, M., Tigora, A., Paic, V., Bratucu, M., Garofil, D., Surlin, V., Munteanu, A. C., Coman, I. S., Popa, F., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084140 · Cited by 30
Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development
Hwang, G.-R., Yuen, J. G., & Ju, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041624 · Cited by 15
Metadata
- Authors
- Munro, M. J., Wickremesekera, S. K., Peng, L., Tan, S. T., & Itinteang, T.
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2017-09-23
- Volume
- 71
- Issue
- 2
- Pages
- 110-116
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W2757008523
- Cited by
- 304
- References
- 10
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cancer stem cells in colorectal cancer: a review. https://app.cochat.ai/papers/10.1136/jclinpath-2017-204739
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- Munro, M. J., Wickremesekera, S. K., Peng, L., Tan, S. T., & Itinteang, T. (2018). Cancer stem cells in colorectal cancer: a review. Journal of Clinical Pathology. https://doi.org/10.1136/jclinpath-2017-204739
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
