Cited by 314Gut microbiota and healthInflammatory Bowel DiseaseMitochondrial Function and Pathology

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer

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Jackson, Dakota N., Theiss, Arianne L.·2020·Gut Microbes

Abstract

The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the intestine as well as in the pathophysiology of diseases including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Emerging evidence suggests that gut microbiota signal to the mitochondria of mucosal cells, including epithelial cells and immune cells. Gut microbiota signaling to mitochondria has been shown to alter mitochondrial metabolism, activate immune cells, induce inflammasome signaling, and alter epithelial barrier function. Both dysbiosis of the gut microbiota and mitochondrial dysfunction are associated with chronic intestinal inflammation and CRC. This review discusses mitochondrial metabolism of gut mucosal cells, mitochondrial dysfunction, and known gut microbiota-mediated mitochondrial alterations during IBD and CRC.

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Crossref · 10.1080/19490976.2019.1592421

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  1. [3]Engelking LR. 2015. Tricarboxylic acid (tca) cycle in textbook of veterinary physiological chemistry. 3rd. Oxford: Elsevier.

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Authors
Jackson, D. N., & Theiss, A. L.
Affiliations
Baylor University Medical Center (US)
Corresponding author
Theiss, Arianne L.
Venue
Gut Microbes
Published
2019-03-26
Volume
11
Issue
3
Pages
285-304
ISSN
  • 1949-0976 (ISSN-L)
  • 1949-0984
OpenAlex
W2923380089
Cited by
312
References
149
Citations by year
2026: 44 · 2025: 51 · 2024: 47 · 2023: 43 · 2022: 71 · 2021: 33 · 2020: 20 · 2019: 3
FWCI
2.83
Type
journal article
Language
en
Open access
Locations
  • Gut Microbes (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Crohn’s and Colitis Foundation (391869)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK117001)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
gut microbiota, mitochondrial signaling, mitochondrial metabolism, mitochondrial dysfunction, intestinal inflammation, inflammatory bowel disease, colorectal cancer, mucosal epithelial cells, immune cells, inflammasome signaling, epithelial barrier function, dysbiosis
MeSH terms
Gastrointestinal Microbiome, Animals, Colitis, Humans, Inflammation, Intestinal Mucosa, Mitochondria, Colorectal Neoplasms, Inflammatory Bowel Diseases, Immunity, Mucosal

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