The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival
Open accessAbstract
Background: Activated leucocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis and tumour progression of malignant melanoma and prostate cancer. Aims: To clarify the expression patterns of ALCAM in colon cancer and to correlate these with clinicopathological parameters, including patient survival. Methods: One hundred and eleven colorectal carcinomas were immunostained for ALCAM (clone MOG/07) using a standard detection system. Cytoplasmic and membranous immunoreactivity were scored semiquantitatively. Fisher’s exact test, χ 2 test for trends, Kaplan–Meier analysis, and Cox’s regression were applied. Results: In colorectal cancer, 58.6% and 30.6% of cases showed strong cytoplasmic and membranous expression of ALCAM, respectively. No significant correlation with patient age, tumour grade, stage, or nodal status was apparent. In survival analyses, membranous ALCAM expression correlated significantly (Cox’s regression, p = 0.028; relative risk, 2.3) with shortened patient survival. Conclusions: ALCAM is frequently upregulated in colorectal cancer and is a new independent prognostic marker, underscoring the importance of ALCAM in tumour progression in this disease.
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Jemal, A., Murray, T., Samuels, A., Ghafoor, A., Ward, E., & Thun, M. J. (2003) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.53.1.5 · Cited by 3,275
Bowen, M. A., Patel, D. D., Li, X., Modrell, B., Malacko, A. R., Wang, W. C., Marquardt, H., Neubauer, M., Pesando, J. M., & Francke, U. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.6.2213 · Cited by 382
Swart, G. W. M. (2002) · European Journal of Cell Biology · doi:10.1078/0171-9335-00256 · Cited by 251
Tumour markers of prognosis in colorectal cancer
McLeod, H. L., & Murray, G. I. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690033 · Cited by 224
van Kempen, L. C. L. T., van den Oord, J. J., van Muijen, G. N. P., Weidle, U. H., Bloemers, H. P. J., & Swart, G. W. M. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64943-7 · Cited by 204
STAMEY, T. A., WARRINGTON, J. A., CALDWELL, M. C., CHEN, Z., FAN, Z., MAHADEVAPPA, M., McNEAL, J. E., NOLLEY, R., & ZHANG, Z. (2001) · Journal of Urology · doi:10.1016/s0022-5347(05)65528-0 · Cited by 192
ALCAM (CD166): its role in hematopoietic and endothelial development
Ohneda, O., Ohneda, K., Arai, F., Lee, J., Miyamoto, T. K., Fukushima, Y., Dowbenko, D. J., Lasky, L. A., & Suda, T. (2001) · Blood · doi:10.1182/blood.v98.7.2134 · Cited by 159
Kristiansen, G., Pilarsky, C. P., Wissmann, C., Stephan, C., Weißbach, L., Loy, V., Loening, S. A., Dietel, M., & Rosenthal, A. (2002) · The Prostate · doi:10.1002/pros.10161 · Cited by 137
Self-citationDegen, W. G. J., van Kempen, L. C. L. T., Gijzen, E. G. A., van Groningen, J. J. M., van Kooyk, Y., Bloemers, H. P. J., & Swart, G. W. M. (1998) · PubMed · Cited by 131
Coordinate Recruitment of E-Cadherin and ALCAM to Cell–Cell Contacts by α-Catenin
Tomita, K., van Bokhoven, A., Jansen, C. F. J., Bussemakers, M. J. G., & Schalken, J. A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.2040 · Cited by 56
Cited by
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer
Dalerba, P., Sahoo, D., Paik, S., Guo, X., Yothers, G., Song, N., Wilcox-Fogel, N., Forgó, E., Rajendran, P. S., Miranda, S. P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506597 · Cited by 470
The role of microRNAs in the regulation of cancer stem cells
Takahashi, R.-U., Miyazaki, H., & Ochiya, T. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2013.00295 · Cited by 118
A seven-gene prognostic model for platinum-treated ovarian carcinomas
Sabatier, R., Finetti, P., Bonensea, J., Jacquemier, J., Adelaide, J., Lambaudie, E., Viens, P., Birnbaum, D., & Bertucci, F. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.219 · Cited by 38
CD166-specific CAR-T cells potently target colorectal cancer cells
He, S., Li, S., Guo, J., Zeng, X., Liang, D., Zhu, Y., Li, Y., Yang, D., & Zhao, X. (2023) · Translational Oncology · doi:10.1016/j.tranon.2022.101575 · Cited by 30
Metadata
- Authors
- Weichert, W., Knösel, T., Bellach, J., Dietel, M., & Kristiansen, G.
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2004-10-27
- Volume
- 57
- Issue
- 11
- Pages
- 1160-1164
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W2113702155
- Cited by
- 264
- References
- 11
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Weichert, W., Knösel, T., Bellach, J., Dietel, M., & Kristiansen, G. (2004). ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival. Journal of Clinical Pathology. https://doi.org/10.1136/jcp.2004.016238
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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