Distribution of ferritin, transferrin and lactoferrin in breast carcinoma tissue
Open accessAbstract
An immunoperoxidase staining technique was used for detecting three major iron binding proteins (ferritin, transferrin and lactoferrin) in 40 breast carcinoma cases and six benign breast proliferative lesions. Ferritin staining was detected mainly in connectival stroma and in histiocytes surrounding neoplastic cells. Few and faint ferritin positivities were also detected in neoplastic cells of 20 carcinoma cases. Transferrin was found inconsistently in myoepithelial cells surrounding normal ductules, or around neoplastic ducts of ductal in situ carcinoma. In eight carcinoma cases, transferrin staining was also positive in neoplastic cells. Lactoferrin was detected only in normal breast epithelial cells and in benign breast proliferative lesions. These immunohistochemical findings may suggest that raised serum ferritin concentrations in breast carcinoma patients might be attributed to stromal reaction rather than to tumour synthesis. Transferrin staining of neoplastic cells in these carcinoma cases appears to be very intriguing, particularly since transferrin is considered an obligate requirement for growing cells, and transferrin receptors have been demonstrated only in dividing cells. On the basis of the immunohistochemical data, lactoferrin might be used as a pointer to benign lesions.
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Ferritin expression is mainly in the stromal compartment of tumor tissue.
“These findings were corroborated by a variety of studies showing ferritin expression mainly in the stromal compartment of tumor tissue [26,27].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [26]
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Iron and cancer: recent insights
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Iron as a central player and promising target in cancer progression
Jung, M., Mertens, C., Tomat, E., & Brüne, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020273 · Cited by 268 · see citing works
“Abbreviations DMT-1 divalent metal transporter 1 EMT epithelial-to-mesenchymal transition FPN ferroportin FT ferritin FTH ferritin heavy chain FTL ferritin light chain IRE iron responsive elements IRP iron regulatory proteins LIP labile iron pool Lcn-2 lipocalin-2 PET positron emission tomography RBC red blood cell UT…”
BackgroundInfluentialJézéquel, P., Campion, L., Spyratos, F., Loussouarn, D., Campone, M., Guérin‐Charbonnel, C., Joalland, M., André, J., Descotes, F., Grenot, C., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.26397 · Cited by 85 · see citing works
Mertens, C., Akam, E. A., Rehwald, C., Brüne, B., Tomat, E., & Jung, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166164 · Cited by 83 · see citing works
- Authors
- Rossiello, R., Carriero, M. V., & Giordano, G. G.
- Affiliations
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- University of Naples Federico II (IT)
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 1984-01
- Volume
- 37
- Issue
- 1
- Pages
- 51-55
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- PMC
- PMC498617
- OpenAlex
- W2084504025
- Cited by
- 72
- References
- 19
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- ferritin, transferrin, lactoferrin, breast cancer, iron-binding proteins, myoepithelial cells, stromal reaction, ductal carcinoma in situ, serum ferritin
- MeSH terms
- Breast, Breast Diseases, Breast Neoplasms, Carcinoma, Carcinoma in Situ, Carcinoma, Intraductal, Noninfiltrating, Adenocarcinoma, Mucinous, Female, Ferritins, Humans, Immunoenzyme Techniques, Lactoferrin, Lactoglobulins, Transferrin
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