The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index.
Immunophenotype of multinucleated and mononuclear cells in giant cell lesions of bone and soft tissue
Open accessAbstract
AIMS: To compare the antigenic phenotype of giant cells in giant cell lesions of bone and soft tissue with that of osteoclasts and macrophage polykaryons. METHODS: Formalin fixed, paraffin wax embedded sections of 106 giant cell lesions, 19 granulomatous, and 14 osteoclast containing lesions were immuno-histochemically stained for leucocyte common antigen (LCA), CD68, and HLA-DR. RESULTS: Osteoclasts and giant cells of giant cell tumour of bone and giant cell reparative granuloma could be distinguished by their generalised absence of HLA-DR reaction from macrophage polykaryons and giant cells in other giant cell lesions of bone and soft tissue. Staining for LCA, CD68, and HLA-DR was useful in distinguishing reactive histiocytic giant cells and osteoclasts from tumour giant cells. CONCLUSIONS: A panel of macrophage associated antigens should be diagnostically useful in differentiating the histological nature of giant cells in various giant cell lesions of bone and soft tissue.
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“Foreign body giant cells in tissue removed from human implant surgeries have been shown in situ to express macrophage-associated membrane molecules such as CD45 (leukocyte common antigen), CD13, CD14, CD15A (Hapten X), CD37, CD39, CD43, and HLA-DR; receptors such as CD16 (FcRIII), CD31 (FcRII), CD35 (C3b receptor), CD71 (transferrin receptor); and adhesion molecules such as CD11a,b,c, CD18 (leukoc”
From Foreign body reaction to biomaterials (2008) · cites this paper as [75]
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Cites
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Cited by
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138
Method for grading breast cancer.
Elston, E., & Ellis, I. O. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.2.189-b · Cited by 201
Localized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials
Higgins, D. M., Basaraba, R. J., Hohnbaum, A. C., Lee, E. J., Grainger, D. W., & Juarrero, M. G. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080962 · Cited by 188
Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivo
Ghanaati, S., Barbeck, M., Orth, C., Willershausen, I., Thimm, B. W., Hoffmann, C., Rasic, A., Sader, R. A., Unger, R. E., Peters, F., et al. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.006 · Cited by 178
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Metadata
- Authors
- Doussis, I. A., Puddle, B., & Athanasou, N. A.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 1992-05
- Volume
- 45
- Issue
- 5
- Pages
- 398-404
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- PMC
- PMC495300
- OpenAlex
- W1982665590
- Cited by
- 63
- References
- 27
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
- Health Sciences › Dentistry › Oral Surgery › Oral and Maxillofacial Pathology
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Keywords
- giant cell lesions, giant cell tumor of bone, giant cell reparative granuloma, osteoclasts, HLA-DR, CD68, CD45, immunophenotype, differential diagnosis, granuloma, bone lesions, soft tissue lesions
- MeSH terms
- Bone Diseases, Bone Neoplasms, HLA-DR Antigens, Humans, Immunoenzyme Techniques, Macrophages, Osteoclasts, Soft Tissue Neoplasms, Giant Cells, Immunophenotyping
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- Doussis, I. A., Puddle, B., & Athanasou, N. A. (1992). Immunophenotype of multinucleated and mononuclear cells in giant cell lesions of bone and soft tissue. Journal of Clinical Pathology. https://doi.org/10.1136/jcp.45.5.398
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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