Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)
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Author(s): Portier, Christopher J; Armstrong, Bruce K; Baguley, Bruce C; Baur, Xaver; Belyaev, Igor; Bellé, Robert; Belpoggi, Fiorella; Biggeri, Annibale; Bosland, Maarten C; Bruzzi, Paolo; Budnik, Lygia Therese; Bugge, Merete D; Burns, Kathleen; Calaf, Gloria M; Carpenter, David O; Carpenter, Hillary M; López-Carrillo, Lizbeth; Clapp, Richard; Cocco, Pierluigi; Consonni, Dario; Comba, Pietro; Craft, Elena; Dalvie, Mohamed Aqiel; Davis, Devra; Demers, Paul A; De Roos, Anneclaire J; DeWitt, Jamie; Forastiere, Francesco; Freedman, Jonathan H; Fritschi, Lin; Gaus, Caroline; Gohlke, Julia M; Goldberg, Marcel; Greiser, Eberhard; Hansen, Johnni; Hardell, Lennart; Hauptmann, Michael; Huang, Wei; Huff, James; James, Margaret O; Jameson, CW; Kortenkamp, Andreas; Kopp-Schneider, Annette; Kromhout, Hans; Larramendy, Marcelo L; Landrigan, Philip J; Lash, Lawrence H; Leszczynski, Dariusz; Lynch, Charles F; Magnani, Corrado; Mandrioli, Daniele; Martin, Francis L; Merler, Enzo; Michelozzi, Paola; Miligi, Lucia; Miller, Anthony B; Mirabelli, Dario; Mirer, Franklin E; Naidoo, Saloshni; Perry, Melissa J; Petronio, Maria Grazia; Pirastu, Roberta; Portier, Ralph J; Ramos, Kenneth S; Robertson, Larry W; Rodriguez, Theresa; Röösli, Martin; Ross, Matt K; Roy, Deodutta; Rusyn, Ivan; Saldiva, Paulo; Sass, Jennifer; Savolainen, Kai; Scheepers, Paul TJ; Sergi, Consolato; Silbergeld, Ellen K; Smith, Martyn T; Stewart, Bernard W; Sutton, Patrice; Tateo, Fabio; Terracini, Benedetto; Thielmann, Heinz W; Thomas, David B; Vainio, Harri; Vena, John E
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Recent studies on pesticides and yields are examples of progress in quantifying the impact of GM crop adoption.
“Examples include the recent studies on pesticides ( 79 ) and yields ( 46 )”
From Environmental impacts of genetically modified crops (2024) · cites this paper as [79]
The Mechanistic information and Summary sections discuss glyphosate, so this is a recent paper about a pesticide. They assess evidence about carcinogenicity, however, not the impact of GM crop adoption or progress in quantifying that impact. The citation supports the pesticide-topic example but not the broader characterization. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThese changes may diminish or even reverse the short-term benefits of pesticide reductions from GM crop adoption.
“These changes may diminish or even reverse the short-term benefits of pesticide reductions from GM crop adoption ( 79 )”
From Environmental impacts of genetically modified crops (2024) · cites this paper as [79]
The Mechanistic information and animal carcinogenicity sections discuss glyphosate toxicity and cancer evidence, not pesticide-use changes after GM crop adoption. Searches for short-term pesticide reductions and GM-crop benefits found no passage addressing whether those benefits may diminish or reverse. The indexed passages provide no page number. (LLM, conf=0.75)
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- Authors
- Portier, C. J., Armstrong, B. K., Baguley, B. C., Baur, X., Belyaev, I., Bellé, R., Belpoggi, F., Biggeri, A., Bosland, M. C., Bruzzi, P., Budnik, L. T., Bugge, M. D., Burns, K., Calaf, G. M., Carpenter, D. O., Carpenter, H. M., López-Carrillo, L., Clapp, R., Cocco, P., Consonni, D., Comba, P., Craft, E., Dalvie, M. A., Davis, D., Demers, P. A., De Roos, A. J., DeWitt, J., Forastiere, F., Freedman, J. H., Fritschi, L., Gaus, C., Gohlke, J. M., Goldberg, M., Greiser, E., Hansen, J., Hardell, L., Hauptmann, M., Huang, W., Huff, J., James, M. O., Jameson, C. W., Kortenkamp, A., Kopp-Schneider, A., Kromhout, H., Larramendy, M. L., Landrigan, P. J., Lash, L. H., Leszczynski, D., Lynch, C. F., Magnani, C., Mandrioli, D., Martin, F. L., Merler, E., Michelozzi, P., Miligi, L., Miller, A. B., Mirabelli, D., Mirer, F. E., Naidoo, S., Perry, M. J., Petronio, M. G., Pirastu, R., Portier, R. J., Ramos, K. S., Robertson, L. W., Rodriguez, T., Röösli, M., Ross, M. K., Roy, D., Rusyn, I., Saldiva, P., Sass, J., Savolainen, K., Scheepers, P. T. J., Sergi, C., Silbergeld, E. K., Smith, M. T., Stewart, B. W., Sutton, P., Tateo, F., Terracini, B., Thielmann, H. W., Thomas, D. B., Vainio, H., Vena, J. E., Vineis, P., Weiderpass, E., Weisenburger, D. D., Woodruff, T. J., Yorifuji, T., Yu, I. J., Zambon, P., Zeeb, H., & Zhou, S.-F.
- Affiliations
- Environmental Health Consultant, Thun, Switzerland
- The University of Sydney (AU)
- University of Auckland (NZ)
- Charité – Universitätsmedizin Berlin (DE)
- Cancer Research Institute of the Slovak Academy of Sciences (SK)
- Laboratoire de Biologie Intégrative des Modèles Marins (FR)
- CesareMaltoni Cancer Research Center, Bentivoglio (Bologna), Italy
- University of Florence (IT)
- University of Illinois Chicago (US)
- Ospedale Policlinico San Martino (IT)
- Universität Hamburg (DE)
- National Institute of Occupational Health (NO)
- Sciencecorps, Lexington, Massachusetts, USA
- University of Tarapacá (CL)
- University at Albany, State University of New York (US)
- Toxicologist, Maplewood, Minnesota, USA
- National Institute of Public Health, Cuernavaca, Morelos, Mexico
- Boston University (US)
- University of Cagliari (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Istituto Superiore di Sanità (IT)
- Environmental Defense Fund (US)
- University of Cape Town (ZA)
- Hebrew University of Jerusalem (IL)
- University of Toronto (CA)
- Department of Environmental and Occupational Health, Drexel University, Philadelphia, Pennsylvania, USA
- East Carolina University (US)
- Regione Lazio (IT)
- University of Louisville (US)
- Curtin University (AU)
- The University of Queensland (AU)
- Virginia Tech (US)
- Université Paris Descartes (FR)
- Epi.Consult GmbH, Musweiler, Germany
- Danish Cancer Society (DK)
- Örebro University Hospital (SE)
- The Netherlands Cancer Institute (NL)
- Peking University (CN)
- National Institute of Environmental Health Sciences (US)
- University of Florida (US)
- CWJ Consulting, LLC, Cape Coral, Florida, USA
- Brunel University of London (GB)
- Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany
- Utrecht University (NL)
- Universidad Nacional de La Plata (AR)
- Icahn School of Medicine at Mount Sinai (US)
- Wayne State University (US)
- Department of Biosciences, University of Helsinki, Helsinki, Finland
- University of Iowa (US)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Cesare Maltoni Cancer Research Center, Bentivoglio (Bologna), Italy
- Lancaster University (GB)
- Department of Prevention, Occupational Health Unit, National Health Service, Padua, Italy
- Istituto per lo Studio e la Prevenzione Oncologica (IT)
- Piedmont Reference Center for Epidemiology and Cancer Prevention (IT)
- City University of New York (US)
- University of KwaZulu-Natal (ZA)
- George Washington University (US)
- Health and Environment-Department of Prevention, Local Health Authority-Empoli, Florence, Italy
- Sapienza University of Rome (IT)
- Louisiana State University (US)
- University of Arizona (US)
- National Autonomous University of Nicaragua (NI)
- Swiss Tropical and Public Health Institute (CH)
- Mississippi State University (US)
- Florida International University (US)
- Texas A&M University (US)
- Universidade de São Paulo (BR)
- Natural Resources Defense Council (US)
- Finnish Institute of Occupational Health (FI)
- Radboud University Medical Center (NL)
- University of Alberta (CA)
- Johns Hopkins University (US)
- University of California, Berkeley (US)
- UNSW Sydney (AU)
- University of California, San Francisco (US)
- Institute of Geosciences and Earth Resources (IT)
- University of Turin (IT)
- German Cancer Research Center (DE)
- University of Washington (US)
- Kuwait University (KW)
- Medical University of South Carolina (US)
- Imperial College London (GB)
- Karolinska Institutet (SE)
- City Of Hope National Medical Center (US)
- Okayama University (JP)
- Hoseo University (KR)
- University of Padua (IT)
- Leibniz Institute for Prevention Research and Epidemiology - BIPS (DE)
- University of South Florida (US)
- Corresponding author
- Portier, Christopher J
- Portier, Ralph J
- ORCID
- Portier, Christopher J
- Armstrong, Bruce K
- Baguley, Bruce C
- Baur, Xaver
- Belyaev, Igor
- Belpoggi, Fiorella
- Biggeri, Annibale
- Bosland, Maarten C
- Bruzzi, Paolo
- Bugge, Merete D
- Calaf, Gloria M
- Carpenter, David O
- Clapp, Richard
- Cocco, Pierluigi
- Consonni, Dario
- Dalvie, Mohamed Aqiel
- Davis, Devra
- Demers, Paul A
- DeWitt, Jamie
- Forastiere, Francesco
- Freedman, Jonathan H
- Fritschi, Lin
- Gaus, Caroline
- Gohlke, Julia M
- Goldberg, Marcel
- Hansen, Johnni
- Hardell, Lennart
- Hauptmann, Michael
- Huang, Wei
- James, Margaret O
- Kortenkamp, Andreas
- Kromhout, Hans
- Landrigan, Philip J
- Lash, Lawrence H
- Lynch, Charles F
- Magnani, Corrado
- Mandrioli, Daniele
- Michelozzi, Paola
- Miligi, Lucia
- Miller, Anthony B
- Mirabelli, Dario
- Mirer, Franklin E
- Naidoo, Saloshni
- Perry, Melissa J
- Pirastu, Roberta
- Portier, Ralph J
- Ramos, Kenneth S
- Robertson, Larry W
- Röösli, Martin
- Roy, Deodutta
- Rusyn, Ivan
- Saldiva, Paulo
- Sass, Jennifer
- Scheepers, Paul T J
- Sergi, Consolato
- Silbergeld, Ellen K
- Smith, Martyn T
- Stewart, Bernard W
- Tateo, Fabio
- Terracini, Benedetto
- Thomas, David B
- Vena, John E
- Vineis, Paolo
- Weiderpass, Elisabete
- Weisenburger, Dennis D
- Woodruff, Tracey J
- Yorifuji, Takashi
- Yu, Il Je
- Zeeb, Hajo
- Venue
- Journal of Epidemiology and Community Health
- Publisher
- BMJ
- Published
- 2016-03-03
- Volume
- 70
- Issue
- 8
- Pages
- 741-745
- ISSN
- 0141-7681 (ISSN-L)
- 0143-005X
- 1470-2738
- PMC
- PMC4975799
- OpenAlex
- W2291686380
- Cited by
- 193
- References
- 15
- Citations by year
- 2026: 3 · 2025: 16 · 2024: 14 · 2023: 17 · 2022: 25 · 2021: 22 · 2020: 23 · 2019: 17 · 2018: 22 · 2017: 23 · 2016: 11
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Epidemiology & Community Health (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- CLOK (University of Central Lancashire) (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- TSpace (University of Toronto) (submittedVersion, cc-by-nc)
- Florida International University Digital Commons (Florida International University) (submittedVersion)
- Florida International University Digital Commons (Florida International University) (submittedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
- The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
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- HighWire Press Open Archive (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by-nc)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- National Institute of Environmental Health Sciences (P30ES005605)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Keywords
- glyphosate, carcinogenicity, International Agency for Research on Cancer, EFSA, cancer risk assessment, public health policy
- MeSH terms
- Glyphosate, Carcinogens, Consumer Product Safety, European Union, Glycine, Herbicides, Humans, International Agencies, Neoplasms, Food Safety
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