Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease: Table 1
Abstract
Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). Objective and methods: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case–control dataset. Results: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders.
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Some regions reveal surprising associations; unexpected connections have emerged among T2D, inflammatory diseases (two loci), and cancer (four loci), including CDKAL1, GCKR, TCF2, JAZF1, and TCF7L2.
“5) Some regions reveal surprising associations. For example, unexpected connections have emerged among T2D, inflammatory diseases (two loci), and cancer (four loci). A single intron of CDKAL1 was found to contain a SNP associated with T2D and insulin secretion defects (99–101, 116), and another with Crohn’s disease and psoriasis (117).”
From Genetic Mapping in Human Disease (2008) · cites this paper as [117]
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Psoriatic Arthritis and Diabetes: A Population-Based Cross-Sectional Study
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Cardiometabolic Comorbidities and the Approach to Patients with Psoriasis
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- Authors
- Wolf, N., Quaranta, M., Prescott, N. J., Allen, M., Smith, R., Burden, A. D., Worthington, J., Griffiths, C. E. M., Mathew, C. G., Barker, J. N., Capon, F., & Trembath, R. C.
- Affiliations
- King's College London (GB)
- University of Manchester (GB)
- Western Infirmary (GB)
- Guy's Hospital (GB)
- Corresponding author
- Trembath, R C
- ORCID
- Venue
- Journal of Medical Genetics
- Publisher
- BMJ
- Published
- 2007-11-09
- Volume
- 45
- Issue
- 2
- Pages
- 114-116
- ISSN
- 0022-2593 (ISSN-L)
- 1468-6244
- OpenAlex
- W2102254371
- Cited by
- 171
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 11 · 2013: 11 · 2012: 17
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Funders
- Wellcome Trust (068545/Z/02))
- Psoriasis Association (ST1/07)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Keywords
- psoriasis, Crohn's disease, type 2 diabetes, pleiotropy, genetic susceptibility loci, CDKAL1, IL12B, IL23R, major histocompatibility complex, chromosome 6p21, chromosome 21q22, immune-mediated inflammatory diseases, genetic overlap
- MeSH terms
- Adult, Alleles, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 6, Crohn Disease, Diabetes Mellitus, Type 2, Female, Gene Frequency, Humans, Male, Psoriasis, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Databases, Genetic
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