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Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease: Table 1
Abstract
Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). Objective and methods: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case–control dataset. Results: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders.
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“5) Some regions reveal surprising associations. For example, unexpected connections have emerged among T2D, inflammatory diseases (two loci), and cancer (four loci). A single intron of CDKAL1 was found to contain a SNP associated with T2D and insulin secretion defects (99–101, 116), and another with Crohn’s disease and psoriasis (117).”
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Pathogenesis and clinical features of psoriasis
Griffiths, C. E. M., & Barker, J. N. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61128-3 · Cited by 2,215
Self-citationReplication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194
Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., & Sakaguchi, S. (2002) · Nature Immunology · doi:10.1038/ni759 · Cited by 1,729
Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,175
Self-citationCargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/511051 · Cited by 1,086
Capon, F., Meglio, P. D., Szaub, J., Prescott, N. J., Dunster, C., Southgate, L., Timms, K. M., Gutin, A., Abkevich, V., Burden, A. D., et al. (2007) · Human Genetics · doi:10.1007/s00439-007-0397-0 · Cited by 407
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Zeggini, 2007, Replication of genome-wide association signals in u.k. samples reveals risk loci for type 2 diabetes., 316, 1336
Cited by
Sorted by citations
Items 101–171 of 171
Shani, U., Ben‐Shabat, N., Qassem, R., Lahat, A., Omar, M., Savin, E., Dotan, A., Patt, Y. S., Fisher, L., Zacay, G., et al. (2024) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848241227037 · Cited by 19
Genetics and the metabolic syndrome
Fanning, E., & O'Shea, D. B. (2017) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2017.09.003 · Cited by 19
Haddad, A., Ashkenazi, R. I., Bitterman, H., Feldhamer, I., Greenberg‐Dotan, S., Lavi, I., Batat, E., Bergman, I., Cohen, A. D., & Zisman, D. (2017) · The Journal of Rheumatology · doi:10.3899/jrheum.161274 · Cited by 18
Immunopathogenesis of Psoriasis
Meglio, P. D., & Nestle, F. O. (2017) · Springer eBooks · doi:10.1007/978-3-319-29785-9_21 · Cited by 23
Connective Tissue Diseases and Psoriasis
Montero, L. C., & Belinchón, I. (2011) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2011.03.003 · Cited by 17
Biomarkers of subclinical atherosclerosis in patients with psoriatic arthritis
Peluso, R., Caso, F., Tasso, M., Sabbatino, V., Lupoli, R., Minno, M. N. D. D., Ursini, F., Costa, L., & Scarpa, R. (2019) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s206931 · Cited by 17
Montero, L. C., & Belinchón, I. (2011) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2011.03.002 · Cited by 17
Psoriasis and metabolic syndrome.
Sales, R., & Torres, T. R. (2014) · PubMed · Cited by 16
Genetic susceptibility to psoriasis: an emerging picture
Smith, R., Warren, R. B., Griffiths, C. E. M., & Worthington, J. (2009) · Genome Medicine · doi:10.1186/gm72 · Cited by 16
Self-citationCognitive Process of Psoriasis and Its Comorbidities: From Epidemiology to Genetics
Gao, J., Shen, X., Ko, R., Huang, C., & Shen, C. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.735124 · Cited by 15
Yuan, Z., & Guo, Y. (2022) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.14375 · Cited by 16
Zapata-Cobo, P., Salvador‐Martín, S., Rodríguez‐Belvís, M. V., Pérez, L. M. P., Clemente, S., Segarra, Ó., Moreno‐Álvarez, A., Fernández-Lorenzo, A., Pérez‐Moneo, B., Montraveta, M., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106859 · Cited by 15
Li, N., Ma, J., Li, K., Guo, C., & Ming, L. (2016) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2016.0112 · Cited by 14
Kaushik, A., Chopra, D., Kaur, K., Gupta, S., & Chopra, P. (2023) · Journal of Psoriasis and Psoriatic Arthritis · doi:10.1177/24755303231199995 · Cited by 14
Yang, Z., Yin, X., Chen, C., Huang, S., Li, X., Yan, J., & Sun, Q. (2022) · Inflammation · doi:10.1007/s10753-022-01664-7 · Cited by 13
Sung, F., Chiu, H., Hung, C.-J., Muo, C., & Fan, K. (2020) · Indian Journal of Dermatology Venereology and Leprology · doi:10.4103/ijdvl.ijdvl_428_18 · Cited by 12
Kоrsakova, Y. L., Korotaeva, T. V., Loginova, Е. Y., Gubar, Е. Е., Алексеевна, В. Е., Vasilenko, A., Kuznetsova, N. A., Михайловна, П. И., & Nasonov, E. L. (2021) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2021-275-281 · Cited by 12
Affections inflammatoires à médiation immunitaire et psoriasis
Delaporte, E. (2008) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(08)70547-7 · Cited by 12
S-adenosylmethionine tRNA modification: unexpected/unsuspected implications of former/new players
Adami, R., & Bottai, D. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.49302 · Cited by 12
Churton, S., Doud, K., & Korman, N. J. (2013) · Expert Review of Dermatology · doi:10.1586/edm.13.23 · Cited by 11
Impaired hapten sensitization in patients with autoimmune disease
Bangsgaard, N., Engkilde, K., Menné, T., Løvendorf, M. B., Jacobsen, G. K., Olsen, J., & Skov, L. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04428.x · Cited by 10
Yang, Y., Gong, Z., Yang, J., Cai, Y., Hong, S., Mao, W., Guo, Z., Qiu, M., Fan, Z., & Cui, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37624 · Cited by 8
Association of METS-IR index with psoriasis in US adults: a cross-sectional study
Liu, H., Liu, C., Wang, T., & Fang, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-77784-x · Cited by 14
Topical Therapies for Psoriasis
Mitra, A., & Atillasoy, E. S. (2012) · InTech eBooks · doi:10.5772/27027 · Cited by 8
Personalized Medicine in Psoriasis: Concept and Applications
Al‐Hoqail, I. A. (2010) · Current Vascular Pharmacology · doi:10.2174/157016110791112223 · Cited by 8
Biobanking across the phenome - at the center of chronic disease research
Imboden, M., & Probst-Hensch, N. M. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-1094 · Cited by 7
De-regulation of diabetic regulatory genes in psoriasis: Deciphering the unsolved riddle
AlFadhli, S. M., Al-Zufairi, A. A. M., Nizam, R., Saffar, H. A., & Al-Mutairi, N. (2016) · Gene · doi:10.1016/j.gene.2016.08.024 · Cited by 7
Examining the Risk of Cardiovascular Disease in Patients with Psoriasis: A Critical Review
Papp, K. A., Poulin, Y. P., & Vieira, A. (2013) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2012.11126 · Cited by 6
Shao, J., Xu, Z., & Xu, Y. C. (2022) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-022-00768-7 · Cited by 6
Ingram, S., McKinley, J. M., Vasey, F. B., Carter, J. D., & Brady, P. G. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20841 · Cited by 6
Psoriasis as a risk factor of cardiovascular diseases
Komorowska, O., Szczerkowska‐Dobosz, A., Purzycka-Bohdan, D., Rawicz-Zegrzda, D., & Dudziak, M. (2014) · Dermatology Review · doi:10.5114/dr.2014.46953 · Cited by 6
Genetik häufiger chronisch-entzündlicher Hauterkrankungen
Rodríguez, E., Eyerich, K., & Weidinger, S. (2011) · Der Hautarzt · doi:10.1007/s00105-010-2053-1 · Cited by 7
Shared Pathophysiology of Inflammatory Bowel Disease and Psoriasis: Unraveling the Connection
Jauregui, W., Abarca, Y. A., Ahmadi, Y., Menon, V. B., Zumárraga, D. A., Gomez, M. C. R., Basri, A., Madala, R. S., Girgis, P. A., & Nazir, Z. (2024) · Cureus · doi:10.7759/cureus.68569 · Cited by 5
[Psoriasis and cardiovascular disease].
Torres, T. R., Sales, R., Vasconcelos, C., & Selores, M. (2013) · PubMed · Cited by 5
McKinley, J. M., Ingram, S., Vasey, F. B., Sharma, N. R., Thareja, S., Carter, J., & Brady, P. G. (2009) · Gastroenterology · doi:10.1016/s0016-5085(09)63059-6 · Cited by 5
Fernández-Obregón, A. C. (2012) · InTech eBooks · doi:10.5772/25894 · Cited by 3
Krušič, M., Jezernik, G., & Potočnik, U. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082024 · Cited by 3
Psoriasis in Norway: a prescription-based registry study of psoriasis-associated comorbidities
Solberg, S. M. (2023) · European Journal of Dermatology · doi:10.1684/ejd.2023.4585 · Cited by 3
Individual disease risk and multimetric analysis of Crohn disease
Gibson, J., Collins, A. R., & Morton, N. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808009105 · Cited by 3
Psoriasis et maladies inflammatoires du tube digestif
Delaporte, E. (2012) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(12)70110-2 · Cited by 3
Chapman, A., & Miedany, Y. M. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-59963-2_4 · Cited by 3
Słuczanowska-Głąbowska, S., Jaworska, W., Staniszewska, M., Tkacz, M., Safranow, K., Łuczkowska, K., Zagrodnik, E., Stecewicz, I., Machaliński, B., & Pawlik, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185254 · Cited by 3
Diabetes is associated with a poor prognosis in patients with psoriasis and coronary artery disease
Zhao, L. Y., Sun, L., Yang, K., Zhang, Z., Li, Z., Wang, M., Zhou, X., Zeng, Y., & Yang, W. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-025-01996-z · Cited by 2
Psoriasis - a review of recent progress, characteristics, diagnostic management
Warzyszak, P., MAŁEK, R., MILCZEK, M., ŻOŁYNIAK, W., TOMASIK, M., HAWRANIK, I., NISKI, S., Żaba, Z., & LISOWSKA, A. (2022) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.13.02.021 · Cited by 2
Luo, Q., An, M., Wu, Y., Wang, J., Mao, Y., Zhang, L., & Wang, C. (2024) · Archives of Dermatological Research · doi:10.1007/s00403-024-03617-6 · Cited by 2
The Heart of Psoriasis: Cardiovascular Alterations and Common Inflammatory Mechanisms
Santillo, E., Marini, L., & Cardinali, L. (2025) · Current Cardiology Reviews · doi:10.2174/011573403x412277250911072530 · Cited by 2
Variation in the CDKAL1 Gene Is Associated With the Titer of Antibodies to GAD
Haupt, A., Guthoff, M., Gallwitz, B., Häring, H., & Fritsche, A. (2008) · Diabetes Care · doi:10.2337/dc08-0756 · Cited by 2
Skroza, N., & Proietti, I. (2016) · Journal of Clinical & Experimental Dermatology Research · doi:10.4172/2155-9554.1000335 · Cited by 2
Laws, P., & Warren, R. B. (2020) · Springer eBooks · doi:10.1007/978-3-030-54859-9_27 · Cited by 2
Laws, P., Young, H. S., & Warren, R. B. (2014) · Springer eBooks · doi:10.1007/978-1-4471-4432-8_21 · Cited by 3
Características clínicas y respuesta a la fototerapia de los pacientes con psoriasis
Vargas, G. A., Ramírez, L. C., Gómez, L. F., Peña, M. N., Vasco, C., Medina, L. J., Contreras, J. A. P., & Velásquez, M. M. (2018) · Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica · doi:10.29176/2590843x.46 · Cited by 1
Augustin, M., & Radtke, M. A. (2019) · Harper's Textbook of Pediatric Dermatology · doi:10.1002/9781119142812.ch27 · Cited by 1
Li, M., & Hanson, T. (2010) · Journal of the Royal Statistical Society Series C (Applied Statistics) · doi:10.1111/j.1467-9876.2010.00741.x · Cited by 1
Cardiovascular Disease in Inflammatory Disorders - Psoriasis and Psoriatic Arthritis
Murad, A. A., & Tobi, A.-M. (2012) · InTech eBooks · doi:10.5772/31651
Neue Entwicklungen in der Psoriasisgenetik
Hüffmeier, U., & Reis, A. (2009) · Medizinische Genetik · doi:10.1007/s11825-009-0196-1
Identification of Genetic and Epigenetic Risk Factors for Psoriasis and Psoratic Arthritis
Liu, Y. (2011) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k74x55th
Torres, F., & María, R. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Systemic Treatment for Psoriasis - a New Biologic Era
Ståhle, M. (2008)
Comorbidities of Nail Psoriasis: From A to Z
Tripuraneni, R., & Kerdel, F. A. (2014) · Springer eBooks · doi:10.1007/978-3-319-08810-5_4
Prevalencia de Síndrome Metabólico en pacientes psoriáticos chilenos
Correa, H., Jara, D., Ramírez, C., Hasbún, P., Correa, I., Cuevas, P., & Orellana, R. R. (2017) · Revista Chilena de Dermatología · doi:10.31879/rcderm.v32i1.24
Genetic predispositions to atopic eczema and psoriasis: survey, meta-analyses and comparison
Schneider, M. (2013) · mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
A CLINICO-EPIDEMIOLOGICAL STUDY OF PSORIASIS IN A TERTIARY CARE HOSPITAL IN PATNA, BIHAR
Shankar, V., Kumar, A., Manadavi, M., Ayushi, A., & Jana, D. (2020) · INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH · doi:10.36106/ijsr/6827780
Psoriasis increased the risk of diabetes: a meta-analysis
ChengDayu, J., Zhang, K., & Qiu, X. Y. (2012)
Komorbiditäten und Psoriasis: Konsequenzen für die Praxis
Gerdes, S., & Mrowietz, U. (2012) · Der Hautarzt
Luminescent responses to predation in the scale worm Harmothoe imbricata
Rivers, T. J., & Perreault, T. R. (2012) · Bowdoin - Digital Commons (Bowdoin College)
Cardiovascular risks in patients with psoriasis (literature review)
Асланчериевич, Х. А., & Руднева, Н. С. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-34-12-17
Psoriasis: From Gene to Clinic
Cash, N. J. (2018) · EMJ Dermatology · doi:10.33590/emjdermatol/10314512
Li, R., Lee, S., Prastein, D. J., & Huddleston, S. J. (2025) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2025.09.010
Murrin, O., Voller, B., Woodward, R. M., Carrasco-Ribelles, L. A., Türkmen, D., Gu, Q., Boddy, K., Farmer, L., Mancini, M., Khalid, S., et al. (2026) · Respiratory Research · doi:10.1186/s12931-026-03726-y
Metadata
- Authors
- Wolf, N., Quaranta, M., Prescott, N. J., Allen, M., Smith, R., Burden, A. D., Worthington, J., Griffiths, C. E. M., Mathew, C. G., Barker, J. N., Capon, F., & Trembath, R. C.
- Affiliations
- King's College London (GB)
- University of Manchester (GB)
- Western Infirmary (GB)
- Guy's Hospital (GB)
- Corresponding author
- Trembath, R C
- ORCID
- Venue
- Journal of Medical Genetics
- Publisher
- BMJ
- Published
- 2007-11-09
- Volume
- 45
- Issue
- 2
- Pages
- 114-116
- ISSN
- 0022-2593 (ISSN-L)
- 1468-6244
- OpenAlex
- W2102254371
- Cited by
- 171
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 11 · 2013: 11 · 2012: 17
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Funders
- Wellcome Trust (068545/Z/02))
- Psoriasis Association (ST1/07)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Keywords
- psoriasis, Crohn's disease, type 2 diabetes, pleiotropy, genetic susceptibility loci, CDKAL1, IL12B, IL23R, major histocompatibility complex, chromosome 6p21, chromosome 21q22, immune-mediated inflammatory diseases, genetic overlap
- MeSH terms
- Adult, Alleles, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 6, Crohn Disease, Diabetes Mellitus, Type 2, Female, Gene Frequency, Humans, Male, Psoriasis, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Databases, Genetic
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