The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Incidence and prevalence of multiple sclerosis in the UK 1990-2010: a descriptive study in the General Practice Research Database
Open accessAbstract
OBJECTIVES: To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK. DESIGN: A descriptive study. SETTING: The study was carried out in the General Practice Research Database (GPRD), a primary care database representative of the UK population. MAIN OUTCOME MEASURES: Incidence and prevalence of MS per 100 000 population. Secular and geographical trends in incidence and prevalence of MS. RESULTS: The prevalence of MS recorded in GPRD increased by about 2.4% per year (95% CI 2.3% to 2.6%) reaching 285.8 per 100 000 in women (95% CI 278.7 to 293.1) and 113.1 per 100 000 in men (95% CI 108.6 to 117.7) by 2010. There was a consistent downward trend in incidence of MS reaching 11.52 per 100 000/year (95% CI 10.96 to 12.11) in women and 4.84 per 100 000/year (95% CI 4.54 to 5.16) in men by 2010. Peak incidence occurred between ages 40 and 50 years and maximum prevalence between ages 55 and 60 years. Women accounted for 72% of prevalent and 71% of incident cases. Scotland had the highest incidence and prevalence rates in the UK. CONCLUSIONS: We estimate that 126 669 people were living with MS in the UK in 2010 (203.4 per 100 000 population) and that 6003 new cases were diagnosed that year (9.64 per 100 000/year). There is an increasing population living longer with MS, which has important implications for resource allocation for MS in the UK.
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Cites
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The changing demographic pattern of multiple sclerosis epidemiology
Koch-Henriksen, N., & Sørensen, P. S. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70064-8 · Cited by 1,191
Validation and validity of diagnoses in the General Practice Research Database: a systematic review
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Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis
Simpson, S., Blizzard, L., Otahal, P., Van der Mei, I., & Taylor, B. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2011.240432 · Cited by 718
Temporal trends in the incidence of multiple sclerosis: A systematic review
Alonso, A., & Hernán, M. A. (2008) · Neurology · doi:10.1212/01.wnl.0000316802.35974.34 · Cited by 694
The UK General Practice Research Database
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Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study
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Timing of birth and risk of multiple sclerosis: population based study
Willer, C. J., Dyment, D. A., Sadovnick, A. D., Rothwell, P. M., Murray, T. J., & Ebers, G. C. (2005) · BMJ · doi:10.1136/bmj.38301.686030.63 · Cited by 451
Pregnancy is associated with a lower risk of onset and a better prognosis in multiple sclerosis
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Inflammation in CNS neurodegenerative diseases
Stephenson, J., Nutma, E., van der Valk, P., & Amor, S. (2018) · Immunology · doi:10.1111/imm.12922 · Cited by 966
Koch-Henriksen, N., Thygesen, L. C., Stenager, E., Laursen, B., & Magyari, M. (2018) · Neurology · doi:10.1212/wnl.0000000000005612 · Cited by 188
Distress improves after mindfulness training for progressive MS: a pilot randomised trial
Bogosian, A., Chadwick, P., Windgassen, S., Norton, S., McCrone, P., Mosweu, I., Silber, E., & Moss-Morris, R. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515576261 · Cited by 135
Disanto, G., Benkert, P., Lorscheider, J., Mueller, S., Vehoff, J., Zecca, C., Ramseier, S., Achtnichts, L., Findling, O., Nedeltchev, K., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0152347 · Cited by 76
Foley, P., Kong, Y., Dirvanskiene, R., valdes-Hernandez, M., Bastiani, M., Murnane, J., Sellar, R., Roberts, N., Pernet, C., Weir, C., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac124 · Cited by 11
Metadata
- Authors
- Mackenzie, I. S., Morant, S. V., Bloomfield, G. A., MacDonald, T. M., & O'Riordan, J.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2013-09-19
- Volume
- 85
- Issue
- 1
- Pages
- 76-84
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2129720713
- Cited by
- 300
- References
- 25
- FWCI
- 18.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mackenzie, I. S., Morant, S. V., Bloomfield, G. A., MacDonald, T. M., & O'Riordan, J. (2014). Incidence and prevalence of multiple sclerosis in the UK 1990-2010: a descriptive study in the General Practice Research Database. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp-2013-305450
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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