The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Neurodegeneration in multiple sclerosis and neuromyelitis optica
Open accessAbstract
Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating diseases of the central nervous system (CNS), having distinct immunological and pathological features. They have two pathogenic components, 'inflammation' and 'neurodegeneration', with different degrees of severity and pathogenetic mechanisms. The target antigen of autoimmunity in NMO is the water channel aquaporin-4 (AQP4), and antibodies directed against this antigen result in astrocyte damage. MS is a disease primarily affecting myelin and oligodendrocytes, but thus far, no MS-specific autoantigen has been identified. The distinct inflammatory processes in these diseases may trigger cascades of events leading to disease-specific neurodegeneration. Damage of the CNS tissue appears to be amplified by mechanisms that are in part shared by the two conditions and involve oxidative burst activation in microglia/macrophages, mitochondrial damage and axonal energy failure, Wallerian degeneration and meningeal inflammation. However, they appear to differ regarding the nature of the inflammatory response, the type and extent of cortical injury, and the type of astrocyte reaction and damage. Here, we provide a detailed comparison of the pathology between MS and NMO, which may help to define shared and disease-specific mechanisms of neurodegeneration in these diseases.
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Watanabe, M., Nakamura, Y., Michalak, Z., Isobe, N., Barro, C., Leppert, D., Matsushita, T., Hayashi, F., Yamasaki, R., Kuhle, J., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000008160 · Cited by 220
Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination
Bankston, A. N., Forston, M. D., Howard, R. M., Andres, K. R., Smith, A. E., Ohri, S. S., Bates, M. L., Bunge, M. B., & Whittemore, S. R. (2019) · Glia · doi:10.1002/glia.23646 · Cited by 112
Positron emission tomography in multiple sclerosis - straight to the target
Bodini, B., Tonietto, M., Airas, L., & Stankoff, B. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00537-1 · Cited by 74
Chevalier, A. C., & Rosenberger, T. A. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14032 · Cited by 50
Relapsing and progressive MS: the sex-specific perspective
Rommer, P. S., Ellenberger, D., Hellwig, K., Haas, J., Pöhlau, D., Stahmann, A., Zettl, U. K., & on behalf of the Scientific Advisory Group of the German MS-Register by the German MS Society (2020) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286420956495 · Cited by 37
Metadata
- Authors
- Kawachi, I., & Lassmann, H.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2016-09-26
- Volume
- 88
- Issue
- 2
- Pages
- 137-145
- ISSN
- 0022-3050 (ISSN-L)
- 1468-330X
- OpenAlex
- W2524845362
- Cited by
- 283
- References
- 109
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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