Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

Chevalier, Amber C.; Rosenberger, Thad A.

doi:10.1111/jnc.14032

Cited by 50Multiple Sclerosis Research StudiesSphingolipid Metabolism and SignalingFatty Acid Research and Health

Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

Chevalier, Amber C., Rosenberger, Thad A.·2017·Journal of Neurochemistry

DOI 10.1111/jnc.14032

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Abstract

Abstract Acetate supplementation increases brain acetyl‐CoA metabolism, alters histone and non‐histone protein acetylation, increases brain energy reserves, and is anti‐inflammatory and neuroprotective in rat models of neuroinflammation and neuroborreliosis. To determine the impact acetate supplementation has on a mouse model of multiple sclerosis, we quantified the effect treatment had on injury progression, spinal cord lipid content, phospholipase levels, and myelin structure in mice subjected to experimental autoimmune encephalomyelitis (EAE). EAE was induced by inoculating mice with a myelin oligodendrocyte glycoprotein peptide fragment (MOG35–55), and acetate supplementation was maintained with 4 g/kg glyceryl triacetate by a daily oral gavage. Acetate supplementation prevented the onset of clinical signs in mice subject to EAE compared to control‐treated mice. Furthermore, acetate supplementation prevented the loss of spinal cord ethanolamine and choline glycerophospholipid and phosphatidylserine in mice subjected to EAE compared to EAE animals treated with water. Treatment increased saturated and monounsaturated fatty acid levels in phosphatidylserine compared to controls suggesting that acetate was utilized to increase spinal cord fatty acid content. Also, acetate supplementation prevented the loss of spinal cord cholesterol in EAE animals but did not change cholesteryl esters. Treatment significantly increased GD3 and GD1a ganglioside levels in EAE mice when compared to EAE mice treated with water. Treatment returned levels of phosphorylated and non‐phosphorylated cytosolic phospholipase A2 (cPLA2) levels back to baseline and based on FluoroMyelin™ histochemistry maintained myelin structural characteristics. Overall, these data suggest that acetate supplementation may modulate lipid metabolism in mice subjected to EAE. image

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Acetate supplementation induces increased acetyl-CoA metabolism, increases histone acetylation, resulting in preserved spinal cord lipid content and essentially preventing the onset of clinical symptoms of EAE.
“Specifically, acetate supplementation is able to induce increased acetyl-CoA metabolism, which increases histone acetylation, resulting in preserved spinal cord lipid content and essentially preventing the onset of clinical symptoms of EAE (179).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [179]
Short-chain fatty acids favor enhancement of acetyl-CoA metabolism, histone acetylation, preservation of spinal cord lipid content, suppression of demyelination, and oligodendrocyte maturation and differentiation.
“Mechanistically, SCFAs favor the enhancement of acetyl-CoA metabolism, histone acetylation, preservation of spinal cord lipid content, suppression of demyelination, oligodendrocyte maturation and differentiation (157, 158).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [157]

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Quantitive estimation of sialic acids
Svennerholm, L. T. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90254-8 · Cited by 2,756 · see citing works
Quantitative analysis of phospholipids by thin‐layer chromatography and phosphorus analysis of spots
Rouser, G., Siakotos, A. N., & Fleischer, S. (1966) · Lipids · doi:10.1007/bf02668129 · Cited by 1,581 · see citing works
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth
McKerracher, L. J., David, S., Jackson, D. L., Kottis, V., Dunn, R. J., & Braun, P. E. (1994) · Neuron · doi:10.1016/0896-6273(94)90247-x · Cited by 1,125 · see citing works
Functions of plasmalogen lipids in health and disease
Braverman, N. E., & Moser, A. B. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.05.008 · Cited by 1,082 · see citing works
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
Mukhopadhyay, G., Doherty, P., Walsh, F. S., Crocker, P. R., & Filbin, M. T. (1994) · Neuron · doi:10.1016/0896-6273(94)90042-6 · Cited by 1,061 · see citing works
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
Baenke, F., Peck, B., Miess, H., & Schulze, A. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.011338 · Cited by 772 · see citing works
Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration
Schnaar, R. L., Gerardy-Schahn, R., & Hildebrandt, H. (2014) · Physiological Reviews · doi:10.1152/physrev.00033.2013 · Cited by 745 · see citing works
Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65
Kiernan, R. E., Brès, V., Ng, R. W. M., Coudart, M.-P., Messaoudi, S. E., Sardet, C., Jin, D., Emiliani, S., & Benkirane, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209572200 · Cited by 536 · see citing works
Peroxisome biogenesis disorders
Steinberg, S. J., Dodt, G., Raymond, G. V., Braverman, N. E., Moser, A. B., & Moser, H. W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.09.010 · Cited by 522 · see citing works
Very long-chain fatty acids: elongation, physiology and related disorders
Kihara, A. (2012) · The Journal of Biochemistry · doi:10.1093/jb/mvs105 · Cited by 441 · see citing works
Untitled work
Moser, H. (1981) · doi:10.1212/wnl.31.10.1241 · Cited by 396 · see citing works
[1] Extraction of tissue lipids with a solvent of low toxicity
Radin, N. S. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)72003-2 · Cited by 361 · see citing works
Phospholipase A2 and Its Role in Brain Tissue
Farooqui, A. A., Yang, H., Rosenberger, T. A., & Horrocks, L. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69030889.x · Cited by 338 · see citing works
Self-citation
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
Chrast, R., Saher, G., Nave, K.-A., & Verheijen, M. H. G. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009761 · Cited by 314 · see citing works
Intraneuronal N ‐acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin‐associated aspartoacylase
Chakraborty, G., Mekala, P., Yahya, D., Wu, G., & Ledeen, R. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00456.x · Cited by 302 · see citing works
Central nervous system myelin: structure, synthesis and assembly
Aggarwal, S., Yurlova, L., & Simons, M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.004 · Cited by 301 · see citing works
The relevance of animal models in multiple sclerosis research
Đenić, A., Johnson, A. J., Bieber, A. J., Warrington, A. E., Rodriguez, M., & Pirko, I. (2010) · Pathophysiology · doi:10.1016/j.pathophys.2010.04.004 · Cited by 300 · see citing works
The molecular basis of neurodegeneration in multiple sclerosis
Lassmann, H., & van Horssen, J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.004 · Cited by 296 · see citing works
Gangliosides are neuronal ligands for myelin-associated glycoprotein.
Yang, L. J., Zeller, C. B., Shaper, N. L., Kiso, M., Hasegawa, A., Shapiro, R. E., & Schnaar, R. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.814 · Cited by 295 · see citing works
Neurodegeneration in multiple sclerosis and neuromyelitis optica
Kawachi, I., & Lassmann, H. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-313300 · Cited by 287 · see citing works
The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial
Singh, N., Hopkins, S. J., Hulme, S., Galea, J. P., Hoadley, M. E., Vail, A., Hutchinson, P. J., Grainger, S., Rothwell, N. J., King, A. T., et al. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-1 · Cited by 284 · see citing works
Peroxisomal disorders: The single peroxisomal enzyme deficiencies
Wanders, R. J. A., & Waterham, H. R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.010 · Cited by 279 · see citing works
Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration
Vyas, A. A., Patel, H. V., Fromholt, S. E., Heffer-Lauc, M., Vyas, K. A., Dang, J., Schachner, M., & Schnaar, R. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072211699 · Cited by 272 · see citing works
Metabolism and functions of lipids in myelin
Schmitt, S., Cantuti‐Castelvetri, L., & Simons, M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.016 · Cited by 259 · see citing works
Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis
Wolswijk, G. (2000) · Brain · doi:10.1093/brain/123.1.105 · Cited by 238 · see citing works
A Rapid and Specific Ultramicro Method for Total Serum Cholesterol
Bowman, R. E., & Wolf, R. C. (1962) · Clinical Chemistry · doi:10.1093/clinchem/8.3.302 · Cited by 222 · see citing works
Identification of the peroxisomal β-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid
Ferdinandusse, S., Denis, S. W., Mooijer, P. A. W., Zhang, Z., Reddy, J. K., Spector, A. A., & Wanders, R. J. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31527-3 · Cited by 210 · see citing works
Gangliosides of human, cat, and rabbit spinal cords and cord myelin.
Ueno, K., Ando, S., & Yu, R. K. (1978) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40700-x · Cited by 209 · see citing works
Peroxisome Biogenesis Disorders
Grønborg, S. W., Gould, S. J., & Valle, D. L. (2003) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.4.070802.110424 · Cited by 203 · see citing works
Mice lacking both subunits of lysosomal β–hexosaminidase display gangliosidosis and mucopolysaccharidosis
Sango, K., McDonald, M. P., Crawley, J. N., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-348 · Cited by 202 · see citing works
Oligodendrocyte lineage and the motor neuron connection
Richardson, W. D., Smith, H., Sun, T., Pringle, N., Hall, A., & Woodruff, R. (2000) · Glia · doi:10.1002/(sici)1098-1136(20000115)29:2 · Cited by 198 · see citing works
Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: Neuropathology and behavioral deficits in single- and double-null mice
Pan, B., Fromholt, S., Hess, E. J., Crawford, T. O., Griffin, J. W., Sheikh, K. A., & Schnaar, R. L. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.04.017 · Cited by 195 · see citing works
Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease.
Kalyvas, A., & David, S. (2004) · Neuron · doi:10.1016/s0896-6273(04)00003-0 · Cited by 181 · see citing works
Peroxisomes, lipid metabolism and lipotoxicity
Wanders, R. J. A., Ferdinandusse, S., Brites, P., & Kemp, S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.01.001 · Cited by 169 · see citing works
A Functional Role for Complex Gangliosides: Motor Deficits in GM2/GD2 Synthase Knockout Mice
Chiavegatto, S., Sun, J., Nelson, R. J., & Schnaar, R. L. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7504 · Cited by 165 · see citing works
ACETATE METABOLISM IN THE NERVOUS SYSTEM. N‐ACETYL‐ l ‐ASPARTIC ACID AND THE BIOSYNTHESIS OF BRAIN LIPIDS*
D’Adamo, A. F., & Yatsu, F. M. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb10292.x · Cited by 162 · see citing works
Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression
Soliman, M. L., & Rosenberger, T. A. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0751-3 · Cited by 158 · see citing works
Self-citation
Brain gangliosides in axon–myelin stability and axon regeneration
Schnaar, R. L. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.011 · Cited by 152 · see citing works
Neuronal injury in chronic CNS inflammation
Zindler, E., & Zipp, F. (2010) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2010.11.001 · Cited by 144 · see citing works
Increased circulating antiganglioside antibodies in primary and secondary progressive multiple sclerosis
Sadatipour, B. T., Greer, J. M., & Pender, M. P. (1998) · Annals of Neurology · doi:10.1002/ana.410440621 · Cited by 139 · see citing works
Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival
Rone, M. B., Cui, Q., Fang, J. Q., Wang, L., Zhang, J., Khan, D., Bedard, M., Almazán, G., Ludwin, S. K., Jones, R., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4077-15.2016 · Cited by 136 · see citing works
Acetate reduces microglia inflammatory signaling <i>in vitro</i>
Soliman, M. L., Puig, K. L., Combs, C. K., & Rosenberger, T. A. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07955.x · Cited by 131 · see citing works
Self-citation
A new dietary therapy for adrenoleukodystrophy: Biochemical and preliminary clinical results in 36 patients
Moser, A. B., Borel, J. S., Odone, A., Naidu, S., Cornblath, D., Sanders, D. B., & Moser, H. W. (1987) · Annals of Neurology · doi:10.1002/ana.410210305 · Cited by 130 · see citing works
The PEX Gene Screen: molecular diagnosis of peroxisome biogenesis disorders in the Zellweger syndrome spectrum
Steinberg, S. J., Chen, L., Wei, L., et al. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.08.008 · Cited by 127 · see citing works
Rat brain arachidonic acid metabolism is increased by a 6‐day intracerebral ventricular infusion of bacterial lipopolysaccharide
Rosenberger, T., Villacreses, N., Hovda, J., Bosetti, F., Weerasinghe, G. R., Wine, R. N., Harry, G., & Rapoport, S. I. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02246.x · Cited by 123 · see citing works
Self-citation
Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders
Martínez, M., Méndez, E. V., García‐Silva, M. T., Manzanares, J., Bertran, J. M., Castelló, F., & Mougan, I. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.376s · Cited by 122 · see citing works
MRI evidence that docosahexaenoic acid ethyl ester improves myelination in generalized peroxisomal disorders
Martínez, M., & Vázquez, É. (1998) · Neurology · doi:10.1212/wnl.51.1.26 · Cited by 122 · see citing works
THE CEREBRAL LIPIDS IN DISSEMINATED SCLEROSIS AND IN AMAUROTIC FAMILY IDIOCY
Cumings, J. N. (1953) · Brain · doi:10.1093/brain/76.4.551 · Cited by 119 · see citing works
Turnover of Myelin Lipids in Aging Brain
Ando, S., Tanaka, Y., Toyoda, Y., & Kon, K. (2003) · Neurochemical Research · doi:10.1023/a:1021635826032 · Cited by 114 · see citing works
Human brain gangliosides in development, aging and disease
Kraĉun, I., Rösner, H., Drnovsek, V., Heffer, M., Cosovi?, C., & Lauc, G. (1991) · The International Journal of Developmental Biology · doi:10.1387/ijdb.1814411 · Cited by 112 · see citing works
HMG‐CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis
Paintlia, A. S., Paintlia, M. K., Khan, M., Vollmer, T. L., Singh, A. K., & Singh, I. (2005) · The FASEB Journal · doi:10.1096/fj.05-3861com · Cited by 107 · see citing works
Actin Polymerization Is Essential for Myelin Sheath Fragmentation during Wallerian Degeneration
Jung, J., Cai, W., Lee, H. K., Pellegatta, M., Shin, Y. K., Jang, S. Y., Suh, D. J., Wrabetz, L. G., Feltri, M. L., & Park, H. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4537-10.2011 · Cited by 106 · see citing works
Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation
Soliman, M. L., Smith, M. D., Houdek, H. M., & Rosenberger, T. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-51 · Cited by 105 · see citing works
Self-citation
Rat brain arachidonic acid metabolism is increased by a 6‐day intracerebral ventricular infusion of bacterial lipopolysaccharide
Rosenberger, T. A., Villacreses, N. E., Hovda, J. T., Bosetti, F., Weerasinghe, G. R., Wine, R. N., Harry, G. J., & Rapoport, S. I. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02613.x · Cited by 105 · see citing works
Self-citation
Specific distribution of short-chain fatty acids in molecular distillates of bovine milk fat
Breckenridge, W. C., & Kuksis, A. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43109-8 · Cited by 104 · see citing works
Adrenoleukodystrophy: Dietary oleic acid lowers hexacosanoate levels
Rizzo, W. B., Phillips, M. W., Dammann, A. L., Leshner, R. T., Jennings, S. S., Avigan, J., & Proud, V. K. (1987) · Annals of Neurology · doi:10.1002/ana.410210304 · Cited by 97 · see citing works
Brain gangliosides: Functional ligands for myelin stability and the control of nerve regeneration
Vyas, A. A., & Schnaar, R. L. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01308-6 · Cited by 95 · see citing works
Plasma and Red Blood Cell Fatty Acids in Peroxisomal Disorders
Moser, A. B., Jones, D. S., Raymond, G. V., & Moser, H. W. (1999) · Neurochemical Research · doi:10.1023/a:1022549618333 · Cited by 93 · see citing works
LIPIDS AND PROTEINS IN MULTIPLE SCLEROSIS WHITE MATTER1
Gerstl, B., Eng, L. F., Tavaststjerna, M. G., et al. (1970) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1970.tb00547.x · Cited by 92 · see citing works
Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism
Gonzalo, H., Brieva, L., Tatzber, F., Jové, M., Cacabelos, D., Cassanyé, A., Lanau-Angulo, L., Boada, J., Serrano, J. C. E., González, C., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07934.x · Cited by 87 · see citing works
Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter
Markoullis, K., Sargiannidou, I., Schiza, N., Hadjisavvas, A., Roncaroli, F., Reynolds, R., & Kleopa, K. A. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0978-4 · Cited by 87 · see citing works
Canavan disease and the role of N-acetylaspartate in myelin synthesis
Namboodiri, A. M. A., Arun, P., Mathew, R., Ariyannur, P. S., Hershfield, J. R., Moffett, J. R., & Madhavarao, C. N. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.016 · Cited by 87 · see citing works
Clinical diagnosis, biochemical findings and MRI spectrum of peroxisomal disorders
Poll-The, B. T., & Gärtner, J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.03.011 · Cited by 85 · see citing works
“Lorenzo’s Oil” Therapy for X-linked Adrenoleukodystrophy: Rationale and Current Assessment of Efficacy
Moser, H. W., Moser, A. B., Hollandsworth, K., Brereton, N. H., & Raymond, G. V. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0041-4 · Cited by 85 · see citing works
Impaired degradation of leukotrienes in patients with peroxisome deficiency disorders.
Mayatepek, E., Lehmann, W. D., Fauler, J., Tsikas, D., Frölich, J. C., Schutgens, R. B. H., Wanders, R. J. A., & KEPPLER, D. O. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116309 · Cited by 84 · see citing works
Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes
Soliman, M. L., Combs, C. K., & Rosenberger, T. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9426-4 · Cited by 84 · see citing works
Self-citation
Developmental expression of GD3 and polysialogangliosides in embryonic chicken nervous tissue reacting with monoclonal antiganglioside antibodies
Rösner, H., Al-Aqtum, M., & Henke‐Fahle, S. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90252-4 · Cited by 82 · see citing works
Canavan disease: A white matter disorder
Kumar, S., Mattan, N. S., & de Vellis, J. (2006) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20108 · Cited by 78 · see citing works
Restoring the DHA Levels in the Brains of Zellweger Patients
Martinez, M. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:309 · Cited by 78 · see citing works
Regulation of oligodendrocyte precursor migration during development, in adulthood and in pathology
de Castro, F., Bribián, A., & Ortega, M. C. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1365-6 · Cited by 75 · see citing works
Acetate supplementation attenuates lipopolysaccharide‐induced neuroinflammation
Reisenauer, C. J., Bhatt, D. P., Mitteness, D. J., Slanczka, E. R., Gienger, H. M., Watt, J. A., & Rosenberger, T. A. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07198.x · Cited by 73 · see citing works
Self-citation
Docosahexaenoic acid therapy in docosahexaenoic acid‐deficient patients with disorders of peroxisomal biogenesis
Martínez, M. (1996) · Lipids · doi:10.1007/bf02637067 · Cited by 73 · see citing works
Metabolic Acetate Therapy for the Treatment of Traumatic Brain Injury
Arun, P., Ariyannur, P. S., Moffett, J. R., Xing, G., Hamilton, K. R., Grunberg, N. E., Ives, J. A., & Namboodiri, A. M. A. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2009.0994 · Cited by 73 · see citing works
Effects of cholesterol and simvastatin treatment in patients with Smith–Lemli–Opitz syndrome (SLOS)
Haas, D., Garbade, S. F., Vohwinkel, C. U., Muschol, N., Trefz, F. K., Penzien, J. M., Zschocke, J., Hoffmann, G. F., & Burgard, P. (2007) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-007-0537-7 · Cited by 73 · see citing works
Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease
Arun, P., Madhavarao, C. N., Moffett, J. R., Hamilton, K. R., Grunberg, N. E., Ariyannur, P. S., Gahl, W. A., Anikster, Y., Mog, S. R., Hallows, W. C., et al. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9100-z · Cited by 71 · see citing works
Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat
Rosenberger, T. A., Oki, J., Purdon, A. D., Rapoport, S. I., & Murphy, E. J. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30187-5 · Cited by 71 · see citing works
Self-citation
Current and Future Therapies for Multiple Sclerosis
Minagar, A. (2013) · Scientifica · doi:10.1155/2013/249101 · Cited by 70 · see citing works
Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid
Sassa, T., Wakashima, T., Ohno, Y., & Kihara, A. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m044586 · Cited by 70 · see citing works
Different antiganglioside antibody pattern between relapsing-remitting and progressive multiple sclerosis
Acarín, N., Río, J., Fernández, A. L., et al. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb00182.x · Cited by 68 · see citing works
Cytoskeletal protein carbonylation and degradation in experimental autoimmune encephalomyelitis
Smerjac, S. M., & Bizzozero, O. A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05178.x · Cited by 68 · see citing works
Myelin
Morell, P. (1984) · Springer eBooks · doi:10.1007/978-1-4757-1830-0 · Cited by 67 · see citing works
Progress toward Acetate Supplementation Therapy for Canavan Disease: Glyceryl Triacetate Administration Increases Acetate, but Not N-Acetylaspartate, Levels in Brain
Mathew, R., Arun, P., Madhavarao, C. N., Moffett, J. R., & Namboodiri, M. A. A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087536 · Cited by 64 · see citing works
Docosahexaenoic acid–A new therapeutic approach to peroxisomal‐disorder patients
Martínez, M., Pineda, M., Vidal, R., Conill, J., & Martin, B. (1993) · Neurology · doi:10.1212/wnl.43.7.1389 · Cited by 64 · see citing works
Acetate as a Metabolic and Epigenetic Modifier of Cancer Therapy
Jaworski, D. M., Namboodiri, A. M. A., & Moffett, J. R. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25305 · Cited by 63 · see citing works
Triacetin‐based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma
Tsen, A. R., Long, P. M., Driscoll, H. E., Davies, M. T., Teasdale, B., Penar, P. L., Pendlebury, W. W., Spees, J. L., Lawler, S. E., Viapiano, M. S., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28465 · Cited by 62 · see citing works
Multiple Sclerosis is Not a Disease of the Immune System
Corthals, A. (2011) · The Quarterly Review of Biology · doi:10.1086/662453 · Cited by 61 · see citing works
Canavan disease: A review of recent developments
Gordon, N. S. (2001) · European Journal of Paediatric Neurology · doi:10.1053/ejpn.2001.0467 · Cited by 60 · see citing works
BRAIN LIPIDS IN MULTIPLE SCLEROSIS AND OTHER DISEASES
Gerstl, B., Mj, K., Smith, J. K., Tavaststjerna, M. G., & HAYMAN, A. R. B. (1961) · Brain · doi:10.1093/brain/84.2.310 · Cited by 60 · see citing works
Multiple sclerosis
Cusick, M. F., Libbey, J. E., & Fujinami, R. S. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328362004d · Cited by 58 · see citing works
Ceramide Synthase 6 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis
Schiffmann, S., Ferreirós, N., Birod, K., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103109 · Cited by 53 · see citing works
A safety trial of high dose glyceryl triacetate for Canavan disease
Segel, R., Anikster, Y., Zevin, S., D, A. S. M., Gahl, W. A., Fisher, D., Staretz‐Chacham, O., Zimran, A., & Altarescu, G. (2011) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2011.03.012 · Cited by 53 · see citing works
Acetate Supplementation as a Means of Inducing Glioblastoma Stem-Like Cell Growth Arrest
Long, P. M., Tighe, S. W., Driscoll, H. E., Fortner, K. A., Viapiano, M. S., & Jaworski, D. M. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.24927 · Cited by 52 · see citing works
Effects of Dietary Cholesterol and Simvastatin on Cholesterol Synthesis in Smith-Lemli-Opitz Syndrome
Chan, Y., Merkens, L. S., Connor, W. E., Roullet, J., Penfield, J. A., Jordan, J. M., Steiner, R. D., & Jones, P. J. H. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31819ea4eb · Cited by 48 · see citing works
Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein
Tilve, S. M., Difato, F., & Chieregatti, E. (2015) · Scientific Reports · doi:10.1038/srep16524 · Cited by 47 · see citing works
Current and future disease-modifying therapies in multiple sclerosis
Lim, S., & Constantinescu, C. S. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02261.x · Cited by 44 · see citing works
Multiple sclerosis is associated with enhanced B cell responses to the ganglioside GD I a
Matà, S., Lolli, F., Söderström, M. B., et al. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500i603 · Cited by 41 · see citing works
Fasudil mediates cell therapy of EAE by immunomodulating encephalomyelitic T cells and macrophages
Liu, C., Guo, S., Yu, J., Lǐ, Y., Zhang, H., Feng, L., Chai, Z., Yuan, H., Yang, W., Feng, Q., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201344429 · Cited by 40 · see citing works
Acetate supplementation reduces microglia activation and brain interleukin-1β levels in a rat model of Lyme neuroborreliosis
Brissette, C. A., Houdek, H. M., Floden, A. M., & Rosenberger, T. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-249 · Cited by 40 · see citing works
Self-citation
Glyceryl triacetate for Canavan disease: A low‐dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model
Madhavarao, C. N., Arun, P., Anikster, Y., Mog, S. R., Staretz‐Chacham, O., Moffett, J. R., Grunberg, N. E., Gahl, W. A., & Namboodiri, A. M. A. (2009) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-009-1155-3 · Cited by 38 · see citing works
Alterations of brain eicosanoid synthetic pathway in multiple sclerosis and in animal models of demyelination: Role of cyclooxygenase-2
Palumbo, S., & Bosetti, F. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.08.008 · Cited by 35 · see citing works
Acetate Reduces PGE2 Release and Modulates Phospholipase and Cyclooxygenase Levels in Neuroglia Stimulated with Lipopolysaccharide
Soliman, M. L., Ohm, J. E., & Rosenberger, T. A. (2013) · Lipids · doi:10.1007/s11745-013-3799-x · Cited by 30 · see citing works
Self-citation
Acetate supplementation modulates brain adenosine metabolizing enzymes and adenosine A2Areceptor levels in rats subjected to neuroinflammation
Smith, M. D., Bhatt, D. P., Geiger, J. D., & Rosenberger, T. A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-99 · Cited by 28 · see citing works
Self-citation
Hexacosanoic and docosanoic acids plasma levels in patients with cerebral childhood and asymptomatic X-linked adrenoleukodystrophy: Lorenzo’s oil effect
Deon, M., Garcia, M. P., Sitta, Â., Barschak, A. G., Coelho, D. D. M., Schimit, G. O., Pigatto, M. C., Jardim, L. B., Wajner, M., Giugliani, R., et al. (2007) · Metabolic Brain Disease · doi:10.1007/s11011-007-9079-9 · Cited by 26 · see citing works
Intravenously injected [1‐14C]arachidonic acid targets phospholipids, and [1‐14C]palmitic acid targets neutral lipids in hearts of awake rats
Murphy, E. J., Rosenberger, T. A., Patrick, C. B., et al. (2000) · Lipids · doi:10.1007/s11745-000-0598-7 · Cited by 25 · see citing works
Self-citation
Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis
Bhatt, D. P., Houdek, H. M., Watt, J. A., & Rosenberger, T. A. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.01.004 · Cited by 24 · see citing works
Self-citation
LIPID BIOSYNTHESIS IN THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS*
Smith, M. E. (1964) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1964.tb06720.x · Cited by 20 · see citing works
Central nervous system lipid alterations in rats with experimental allergic encephalomyelitis and its suppression by immunosuppressive drugs
Roth, G. A., Monferrán, C. G., Maggio, B., et al. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90600-2 · Cited by 13 · see citing works
The lipid composition of pure myelin in some demyelinating disorders.
Cumings, J. N. (1970) · PubMed · Cited by 12 · see citing works
Acetate Treatment Increases Fatty Acid Content in LPS‐Stimulated BV2 Microglia
Bhatt, D. P., & Rosenberger, T. A. (2014) · Lipids · doi:10.1007/s11745-014-3911-x · Cited by 10 · see citing works
Self-citation
Defective Degradation of Leukotrienes in Peroxisomal-Deficient Human Hepatocytes
Mayatepek, E., & Tiepelmann, B. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1478 · Cited by 8 · see citing works
Effects of Propranolol on Renin Release during Chronic Thoracic Caval Constriction or Acute Renal Artery Stenosis in Dogs
Hanson, R., Davis, J. O., & Freeman, R. H. (1976) · Experimental Biology and Medicine · doi:10.3181/00379727-152-39366 · Cited by 6 · see citing works
Lipid changes in central nervous system membranes in experimental allergic encephalomyelitis (EAE)
Salvati, S., Attorri, L., Confaloni, A., et al. (1990) · Neurochemical Research · doi:10.1007/bf01101703 · Cited by 4 · see citing works
Changes in Phospholipid Composition of the Spinal Cord in Rabbits with Allergic Encephalomyelitis as an Experimental Model of Multiple Sclerosis
Revina, E. S., Gromova, N. V., & Timoshina, T. E. (2011) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-011-1494-6 · Cited by 3 · see citing works
Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.
(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2 · see citing works
Disturbance of lipid composition in spinal cord of rabbits with experimental allergic encephalomyelitis
Np, T. (1985) · Neurochemical Research · doi:10.1007/bf02430599 · Cited by 1 · see citing works
Session 4 Roundtable Discussion: The Roles of DHA in Zellweger Syndrome, A Representative Peroxisomal Biogenesis Disorder
A, N. A. N. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:317 · Cited by 1 · see citing works

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The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
“Comparatively, gut to CNS signaling has been studied for a short period, and Abbreviations: Aβ, amyloid-β peptide; AD, Alzheimer’s disease; ASD, autism spectrum disorder; αSyn, α-synuclein; BBB, blood-brain barrier; BDNF, brainderived neurotrophic factor; BHB, β-hydroxybutyrate; CNS, central nervous system; DA, dopami…”
Background
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS
Liu, L., Huh, J. R., & Shah, K. (2022) · eBioMedicine · doi:10.1016/j.ebiom.2022.103908 · Cited by 344 · see citing works
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
The microbiota–microglia axis in central nervous system disorders
Mossad, O., & Erny, D. (2020) · Brain Pathology · doi:10.1111/bpa.12908 · Cited by 98 · see citing works
Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
Li, K., Wei, S., Hu, L., Yin, X., Mai, Y., Jiang, C., Peng, X., Cao, X., Huang, Z., Zhou, H., et al. (2020) · Mediators of Inflammation · doi:10.1155/2020/2058272 · Cited by 92 · see citing works

"Lipopolysaccharide-induced animal models for neuroinflammation – An overview."
Silva, A., Fiadeiro, M. B., Bernardino, L. I., Fonseca, C. P., Baltazar, G., & Cristóvão, A. C. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578273 · Cited by 76 · see citing works
Role of Neuroinflammation in the Trajectory of Alzheimer’s Disease and in vivo Quantification Using PET
Edison, P., & Brooks, D. J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179929 · Cited by 62 · see citing works
Characterisation of ReNcells CX and VM stimulated with interleukin-1β and lipopolysaccharide
Cheung, K. A. K., Abeysinghe, P., Vaswani, K., et al. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105326 · Cited by 4 · see citing works
Neuroinflammation and oxidative injury in developmental neurotoxicity
Milatović, D., Zaja‐Milatovic, S., BREYER, R. M., Aschner, M., & Montine, T. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382032-7.10064-5 · Cited by 13 · see citing works
Insights into the advances in therapeutic drugs for neuroinflammation-related diseases
Luo, B. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2023.2260088 · Cited by 7 · see citing works

Authors: Chevalier, A. C., & Rosenberger, T. A.
Affiliations: University of North Dakota (US)
Corresponding author: Rosenberger, Thad A.
ORCID: Rosenberger, Thad A.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2017-05-02
Volume: 141
Issue: 5
Pages: 721-737
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/jnc.14032
OpenAlex: W2604611003
Cited by: 50
References: 117
Citations by year: 2025: 4 · 2024: 7 · 2023: 6 · 2022: 21 · 2021: 4 · 2020: 6 · 2019: 1 · 2018: 1
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: UND SMHS Seed Grant
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: acetate supplementation, acetyl-CoA metabolism, experimental autoimmune encephalomyelitis, multiple sclerosis, phospholipase A2, gangliosides, phosphatidylserine, myelin structure, triacetin, neuroinflammation, cholesterol, fatty acid composition, myelin oligodendrocyte glycoprotein
MeSH terms: Acetates, Acetyl Coenzyme A, Animals, Behavior, Animal, Chromatography, Thin Layer, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Fatty Acids, Female, Mice, Inbred C57BL, Myelin Sheath, Peptide Fragments, Spinal Cord, Triglycerides, Statistics, Nonparametric, Lipid Metabolism, Mice, Phospholipases A2, Myelin-Oligodendrocyte Glycoprotein

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Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

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