Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition
Open accessAbstract
Objective: To explore if changes over time of plasma phosphorylated tau (p-tau)181 and neurofilament light chain (NfL) predict future tau and amyloid β (Aβ) PET load and cognitive performance, we studied a subsample of the Alzheimer’s disease (AD) neuroimaging cohort with longitudinal blood peptide assessments. Methods: Eight hundred and sixty-five AD Neuroimaging Initiative participants were included. Using established AD cut-points for the cerebrospinal fluid concentrations of Aβ42, total-tau and p-tau181, subjects were classified according to the National Institute on Aging-Alzheimer’s Association research framework, grouping markers into those of Aβ deposition (A), tau pathology (T) and neurodegeneration (N). Analysis of variance was used to compare the plasma biomarker data between the ATN groups. The rate of change over time of p-tau181 and NfL was obtained from linear mixed effects models and compared between the ATN groups. Linear regression analysis was used to investigate the association of baseline plasma biomarker concentrations and rates of change with future PET tau and Aβ load and cognitive performance. Results: P-tau181 and NfL plasma concentrations increased along the AD spectrum, but only NfL showed greater rates of change in AD patients versus controls. Cognitive performance was associated cross-sectionally with NfL in all subgroups, and with p-tau181 only in AD spectrum individuals. The baseline concentrations of both plasma markers predicted PET Aβ and tau load and cognitive performance. The rate of change of NfL predicted future PET tau and cognitive performance. Conclusions: P-tau and NfL behave differently within the same individuals over time and may therefore offer complementary diagnostic information. Trial registration number: NCT02854033 , NCT01231971 .
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Plasma tau has emerged as a marker of neuronal distress and appears in several neurodegenerative diseases, including preclinical AD.
“Like NfL (neurofilament light chain), plasma tau has emerged as a marker of neuronal distress. It appears in several different neurodegenerative diseases, including importantly even preclinical AD patients (76–85).”
From All the Tau We Cannot See (2023) · cites this paper as [84]
Most studies do not show that levels of plasma phospho-tau predict rate of progression, and plasma NfL outperformed plasma phospho-tau 181 in a longitudinal study.
“Most studies do not show that the levels of plasma phospho-tau predict the rate of progression, and in a longitudinal study, plasma NfL outperformed plasma phospho-tau 181 in this regard (84).”
From All the Tau We Cannot See (2023) · cites this paper as [84]
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NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537 · see citing works
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610 · see citing works
Permutation inference for the general linear model
Winkler, A. M., Ridgway, G. R., Webster, M. A., Smith, S. M., & Nichols, T. E. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.060 · Cited by 3,563 · see citing works
Palmqvist, S., Janelidze, S., Quiroz, Y. T., Zetterberg, H., Lopera, F., Stomrud, E., Su, Y., Chen, Y., Serrano, G. E., Leuzy, A., et al. (2020) · JAMA · doi:10.1001/jama.2020.12134 · Cited by 1,603 · see citing works
Karikari, T. K., Pascoal, T. A., Ashton, N. J., Janelidze, S., Benedet, A. L., Rodriguez, J. L., Chamoun, M., Savard, M., Kang, M. S., Therriault, J., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30071-5 · Cited by 1,316 · see citing works
Janelidze, S., Mattsson, N., Palmqvist, S., Smith, R., Beach, T. G., Serrano, G. E., Chai, X., Proctor, N. K., Eichenlaub, U., Zetterberg, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0755-1 · Cited by 1,247 · see citing works
Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease
Mattsson, N., Andreasson, U., Zetterberg, H., Blennow, K., & Initiative, F. T. A. D. N. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.6117 · Cited by 1,070 · see citing works
Dominantly Inherited Alzheimer Network, Preische, O., Schultz, S. A., Apel, A., Kuhle, J., Kaeser, S. A., Barro, C., Gräber, S., Kuder-Buletta, E., LaFougere, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0304-3 · Cited by 927 · see citing works
Bridel, C., van Wieringen, W. N., Zetterberg, H., Tijms, B. M., Teunissen, C. E., and the NFL Group, Alvarez-Cermeño, J. C., Andreasson, U., Axelsson, M., Bäckström, D. C., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1534 · Cited by 764 · see citing works
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators, Thijssen, E. H., La Joie, R., Wolf, A., Strom, A., Wang, P., Iaccarino, L., Bourakova, V., Cobigo, Y., Heuer, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0762-2 · Cited by 761 · see citing works
Müller‐Gärtner, H. W., Links, J. M., Prince, J. L., Bryan, R. N., McVeigh, E. R., Leal, J. P., Davatzikos, C. A., & Frost, J. J. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.81 · Cited by 756 · see citing works
Mattsson, N., Cullen, N. C., Andreasson, U., Zetterberg, H., & Blennow, K. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.0765 · Cited by 726 · see citing works
Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects
Mormino, E. C., Kluth, J. T., Madison, C. M., Rabinovici, G. D., Baker, S. L., Miller, B. L., Koeppe, R. A., Mathis, C. A., Weiner, M. W., Jagust, W. J., et al. (2009) · Brain · doi:10.1093/brain/awn320 · Cited by 684 · see citing works
Initiative, A. D. N., Crane, P. K., Carle, A. C., Gibbons, L. E., Insel, P. S., Mackin, R. S., Gross, A. L., Jones, R. N., Mukherjee, S., Curtis, S. M., et al. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9186-z · Cited by 615 · see citing works
Plasma tau in Alzheimer disease
Mattsson, N., Zetterberg, H., Janelidze, S., Insel, P. S., Andreasson, U., Stomrud, E., Palmqvist, S., Baker, D., Tan Hehir, C. A., Jeromin, A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003246 · Cited by 502 · see citing works
Longitudinal tau PET in ageing and Alzheimer’s disease
Jack, C. R., Wiste, H. J., Schwarz, C. G., Lowe, V. J., Senjem, M. L., Vemuri, P., Weigand, S. D., Therneau, T. M., Knopman, D. S., Gunter, J. L., et al. (2018) · Brain · doi:10.1093/brain/awy059 · Cited by 452 · see citing works
de Wolf, F., Ghanbari, M., Licher, S., McRae‐McKee, K., Gras, L. A., Weverling, G. J., Wermeling, P. R., Sedaghat, S., Ikram, M. K., Waziry, R., et al. (2020) · Brain · doi:10.1093/brain/awaa054 · Cited by 328 · see citing works
Greve, D. N., Salat, D. H., Bowen, S., Izquierdo‐Garcia, D., Schultz, A. P., Catana, C., Becker, J. A., Svarer, C., Knudsen, G. M., Sperling, R. A., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.042 · Cited by 312 · see citing works
Plasma and CSF neurofilament light
Mielke, M. M., Syrjanen, J. A., Blennow, K., Zetterberg, H., Vemuri, P., Skoog, I. G., Machulda, M. M., Kremers, W. K., Knopman, D. S., Jack, C. R., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007767 · Cited by 291 · see citing works
Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data
Greve, D. N., Svarer, C., Fisher, P. M., Feng, L., Hansen, A. E., Baare, W., Rosen, B., Fischl, B., & Knudsen, G. M. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.12.021 · Cited by 264 · see citing works
Blennow, K., Shaw, L. M. J., Stomrud, E., Mattsson, N., Toledo, J. B., Buck, K., Wahl, S., Eichenlaub, U., Lifke, V., Simon, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54204-z · Cited by 193 · see citing works
Forgrave, L. M., Ma, M., Best, J. R., & DeMarco, M. L. (2019) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.08.009 · Cited by 177 · see citing works
Vergallo, A., Mégret, L., Lista, S., Cavedo, E., Zetterberg, H., Blennow, K., Vanmechelen, E., Vos, A. D., Habert, M., Potier, M., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.03.009 · Cited by 173 · see citing works
Quiroz, Y. T., Zetterberg, H., Reiman, E. M., Chen, Y., Su, Y., Fox-Fuller, J. T., Garcia, G., Villegas, A., Sepulveda-Falla, D., Villada, M., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30137-x · Cited by 159 · see citing works
Adjusting the effect of nonstationarity in cluster-based and TFCE inference
Salimi‐Khorshidi, G., Smith, S. M., & Nichols, T. E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.088 · Cited by 150 · see citing works
Dickstein, D., Gasperi, R. D., Sosa, M. G., Pérez-García, G., Short, J., Sosa, H., Perez, G. M., Tschiffely, A. E., Dams-O'Connor, K., Pullman, M., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0674-z · Cited by 86 · see citing works
Introduction to special issue: Overview of Alzheimer's Disease Neuroimaging Initiative
Weiner, M. W., & Veitch, D. P. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.05.007 · Cited by 84 · see citing works
Sánchez‐Valle, R., Heslegrave, A., Foiani, M. S., Bosch, B., Antonell, A., Balasa, M., Lladó, A., Zetterberg, H., & Fox, N. C. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0439-y · Cited by 83 · see citing works
The transformative potential of plasma phosphorylated tau
Jack, C. R. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30112-5 · Cited by 12 · see citing works
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Jung, Y., & Damoiseaux, J. S. (2023) · Brain · doi:10.1093/brain/awad267 · Cited by 117 · see citing works
Veitch, D. P., Weiner, M. W., Miller, M., Aisen, P. S., Ashford, M. A., Beckett, L. A., Green, R. C., Harvey, D., Jack, C. R., Jagust, W., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13449 · Cited by 113 · see citing works
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Perneczky, R., Dom, G., Chan, A., Falkai, P., & Bassetti, C. (2024) · European Journal of Neurology · doi:10.1111/ene.16049 · Cited by 106 · see citing works
Self-citationGarcía-Morales, V., González-Acedo, A., Melguizo-Rodríguez, L., Pardo-Moreno, T., Costela-Ruiz, V. J., Montiel-Troya, M., & Ramos-Rodríguez, J. J. (2021) · Biomedicines · doi:10.3390/biomedicines9121910 · Cited by 104 · see citing works
Longitudinal changes in Alzheimer's‐related plasma biomarkers and brain amyloid
Bilgel, M., An, Y., Walker, K. A., Moghekar, A., Ashton, N. J., Kac, P. R., Karikari, T. K., Blennow, K., Zetterberg, H., Jedynak, B., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13157 · Cited by 89 · see citing works
Dark, H. E., An, Y., Duggan, M. R., Joynes, C. M., Davatzikos, C. A., Erus, G., Lewis, A., Moghekar, A., Resnick, S. M., & Walker, K. A. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01459-y · Cited by 51 · see citing works
Hyman, B. (2023) · Annual Review of Medicine · doi:10.1146/annurev-med-042921-023749 · Cited by 39 · see citing works
Xie, L., Das, S. R., Wisse, L. E. M., Ittyerah, R., de Florès, R., Shaw, L. M. J., Yushkevich, P. A., Wolk, D. A., & Initiative, A. D. N. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01210-z · Cited by 39 · see citing works
McGrath, E. R., Beiser, A., O’Donnell, A., Yang, Q., Ghosh, S., Gonzales, M. M., Himali, J. J., Satizábal, C. L., Johnson, K. A., Tracy, R. P., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215639 · Cited by 34 · see citing works
Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease
Pagonabarraga, J., Pérez‐González, R., Bejr‐Kasem, H., Marín‐Lahoz, J., Horta‐Barba, A., Martínez‐Horta, S., Aracil‐Bolaños, I., Sampedro, F., Campolongo, A., Rivas, E. I., et al. (2022) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2022.05.020 · Cited by 33 · see citing works
Sun, Q., Ni, J., Wei, M., Long, S., Li, T., Fan, D., Lü, T., Shi, J., & Tian, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.963845 · Cited by 31 · see citing works
Zheng, H., Wu, Z., Mielke, M. M., Murray, A. M., & Ryan, J. L. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.142 · Cited by 30 · see citing works
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Saunders, T. S., Pozzolo, F. E., Heslegrave, A., King, D., McGeachan, R. I., Spires-Jones, M. P., Harris, S. E., Ritchie, C. W., Terrera, G. M., Deary, I. J., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad113 · Cited by 29 · see citing works
Zhang, Y., Bi, K., Zhou, L., Wang, J., Huang, L., Sun, Y., Peng, G., & Wu, W. (2024) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s471174 · Cited by 28 · see citing works
Xiao, Z., Wu, W., Ma, X., Liang, X., Lu, J., Zheng, L., Ding, S., Lei, Q., Luo, J., Chen, K., et al. (2022) · Clinical Chemistry · doi:10.1093/clinchem/hvac149 · Cited by 28 · see citing works
O’Bryant, S. E., Petersen, M. E., Hall, J. R., Large, S., Johnson, L. A., HABS-HD Study Team, O’Bryant, S. E., Yaffe, K. S., Toga, A. W., Rissman, R. A., et al. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac169 · Cited by 26 · see citing works
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Zhong, H., Zhou, X., Uhm, H., Jiang, Y., Cao, H., Chen, Y., Mak, T. T. W., Lo, R. M. N., Wong, B. W. Y., Cheng, E. Y. L., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13691 · Cited by 25 · see citing works
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Huang, Y., Li, Y., Xie, F., & Guo, Q. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13962 · Cited by 19 · see citing works
Ni, M., Zhu, Z., Gao, F., Dai, L., Lv, X., Wang, Q., Zhu, X., Xie, J.-K., Shen, Y., Wang, S., et al. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00636 · Cited by 20 · see citing works
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Hu, Q., Shi, M., Li, Y., & Zhao, X. (2024) · BMC Neurology · doi:10.1186/s12883-024-03728-7 · Cited by 19 · see citing works
Ankeny, S. E., Bacci, J. R., Decourt, B., Sabbagh, M. N., & Mielke, M. M. (2024) · Neurology and Therapy · doi:10.1007/s40120-024-00658-x · Cited by 17 · see citing works
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Kang, S. H., Lee, E. H., Kim, Y. J., Jang, H., Shin, D., Zetterberg, H., Blennow, K., González‐Ortiz, F., Ashton, N. J., Yun, J., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.8842 · Cited by 15 · see citing works
Adami, P. V. M., Chatterjee, M., Kleineidam, L., Weyerer, S. B., Bickel, H., Wiese, B., Riedel-Heller, S. G., Scherer, M., Blennow, K., Zetterberg, H., et al. (2024) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2024.101030 · Cited by 15 · see citing works
Antonioni, A., Raho, E. M., Manzoli, L., Koch, G., Flacco, M., & Lorenzo, F. D. (2025) · Alzheimer's & Dementia · doi:10.1002/dad2.70068 · Cited by 22 · see citing works
Blood biomarkers for clinical applications in Alzheimer's disease: A narrative review
Li, H., & Wang, Z. (2025) · NeuroMarkers. · doi:10.1016/j.neumar.2025.100078 · Cited by 15 · see citing works
Cianflone, A., Coppola, L., Mirabelli, P., & Salvatore, M. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210496 · Cited by 14 · see citing works
Nashiro, K., Yoo, H. J., Cho, C., Kim, A. J., Nasseri, P., Min, J., Dahl, M. J., Mercer, N., Choupan, J., Choi, P., et al. (2024) · Trials · doi:10.1186/s13063-024-07943-y · Cited by 12 · see citing works
Li, Q., Su, S., Feng, Y., Jia, M., Zhan, J., Liao, Z., Li, J., Li, X., & Initiative, A. D. N. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14056 · Cited by 13 · see citing works
SSRIs reduce plasma tau and restore dorsal raphe metabolism in Alzheimer's disease
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Thomas, K., Spin, P. J., Sir, N., Hou, K. Y., Ashton, N. J., Zetterberg, H., Miller, S., Pringle, C., Stefanacci, R. G., Wischik, C. M., et al. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251379878 · Cited by 12 · see citing works
Li, J., Yang, M., Wei, R., Cao, Y., Xu, F., & Zhang, S. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231080 · Cited by 13 · see citing works
Wischik, C. M., Stefanacci, R. G., Bentham, P., Gauthier, S. G., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A. S., MacSweeney, E., Ballard, C. G., et al. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2026.100480 · Cited by 11 · see citing works
Phosphorylated tau in Alzheimer’s disease
Telser, J., Grossmann, K., Wohlwend, N., Risch, L., Saely, C. H., & Werner, P. (2023) · Advances in clinical chemistry · doi:10.1016/bs.acc.2023.05.001 · Cited by 11 · see citing works
Perna, L., Mons, U., Stocker, H. R., Beyer, L., Beyreuther, K. T., Trares, K., Holleczek, B., Schöttker, B., Perneczky, R., Gerwert, K. B., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12933 · Cited by 10 · see citing works
Self-citationDoes serum neurofilament light help predict accelerated cognitive ageing in unimpaired older adults?
Collins, J. M., Bindoff, A. D., Roccati, E., Alty, J., Vickers, J. C., & King, A. E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1237284 · Cited by 10 · see citing works
Cogswell, P. M., Wiste, H. J., Therneau, T. M., Griswold, M. E., Mattsson, N., Palmqvist, S., Binette, A. P., Stomrud, E., Bateman, R. J., Barthélemy, N. R., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70625 · Cited by 9 · see citing works
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Cogswell, P. M., Lundt, E. S., Therneau, T. M., Hu, M., Griswold, M. E., Wiste, H. J., Machulda, M. M., Stricker, N. H., Braunstein, J. B., West, T., et al. (2026) · Brain · doi:10.1093/brain/awag075 · Cited by 4 · see citing works
Bolton, C. J., Steinbach, M., Khan, O. A., Liu, D., O’Malley, J., Dumitrescu, L. C., Peterson, A. J., Jefferson, A. L., Hohman, T. J., Zetterberg, H., et al. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70047 · Cited by 4 · see citing works
Hu, Q., Shi, M., Li, Y., & Zhao, X. (2024) · Research Square · doi:10.21203/rs.3.rs-3946421/v1 · Cited by 4 · see citing works
Evaluation of a panel of plasma biomarkers for Alzheimer's disease in a diverse research cohort
Dubois, K. N., Pal, S., Reader, J. M., Jackman, B. M., Perkins, M., Khobeir, N., Bakulski, K. M., Heidebrink, J. L., Hampstead, B. M., Morgan, D., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251393405 · Cited by 3 · see citing works
ATN profile classification across two independent prospective cohorts
Peretti, D. E., Ribaldi, F., Scheffler, M., Mu, L., Treyer, V., Gietl, A. F., Höck, C., Frisoni, G. B., & Garibotto, V. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1168470 · Cited by 3 · see citing works
das Neves, P. L., Durães, J., Silva‐Spínola, A., Lima, M., Leitão, M. J., Tábuas‐Pereira, M., Santana, I. J., & Baldeiras, I. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221208 · Cited by 3 · see citing works
Meyer, S. D., Alali, S., Laroy, M., Casteele, T. V., Cauwenberge, M. G. A. V., Goossens, J., Rocker, C. D., Vanbrabant, J., Vanmechelen, E., den Stock, J. V., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf207 · Cited by 3 · see citing works
Alzheimer's Disease : Current Landscape and Future Directions
Kaur, R., Duvey, B. K., Anjali, Vashisht, M., Goel, V., Nidhi, Kumar, V., & Bhargava, A. (2024) · International Journal of Scientific Research in Science and Technology · doi:10.32628/ijsrst24115100 · Cited by 2 · see citing works
Lian, Q., Sun, Q., Han, X., Ma, H., Guo, J., Wen, B., Wang, P. Y., Li, R., Shan, A., Cui, T., et al. (2026) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2026.2671206 · Cited by 2 · see citing works
Gao, Z., Zhu, W., Li, Y., Ye, W., Cheng, X. J., Zhou, S., Li, X., Li, X., Yu, Y., & Initiative, T. A. D. N. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241296130 · Cited by 2 · see citing works
Xu, J., Doig, A. J., Michopoulou, S. K., Proitsi, P., Costen, F., & initiative, T. A. D. N. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1559459 · Cited by 1 · see citing works
APOE and plasma AD biomarkers: The role of genetic ancestry in Hispanics/Latinos
Cheung, C., Anita, N. Z., Filigrana, P. A., Fornage, M., Gonzalez, K. A., Gallo, L. C., Isasi, C. R., Kaplan, R. C., Li, X., Márquez, F., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71213 · Cited by 1 · see citing works
Case analysis of early-onset Alzheimer's disease associated with TBK1 p.Tyr235Phe gene mutation
Li, P., Yuanyuan, Y., Cai, H., Zhang, H., & Zhou, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.993399 · Cited by 1 · see citing works
Wei, M., Wang, L., Yu, X., Hu, W., Wang, M., Zhang, Q., Guo, T., Zhong, J., Li, C., Jiang, J., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70264
Xie, L., Das, S. R., Wisse, L. E. M., Ittyerah, R., de Florès, R., Shaw, L. M., Yushkevich, P. A., & Wolk, D. A. (2023) · Figshare · doi:10.6084/m9.figshare.22625699
Dark, H. E., An, Y., Duggan, M. R., Joynes, C. M., Davatzikos, C. A., Erus, G., Lewis, A., Moghekar, A. R., Resnick, S. M., & Walker, K. A. (2024) · Figshare · doi:10.6084/m9.figshare.26714290
Nashiro, K., Yoo, H. J., Cho, C., Kim, A. J., Nasseri, P., Min, J., Dahl, M. J., Mercer, N., Choupan, J., Choi, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25422333
Dark, H. E., An, Y., Duggan, M. R., Joynes, C. M., Davatzikos, C. A., Erus, G., Lewis, A., Moghekar, A. R., Resnick, S. M., & Walker, K. A. (2024) · Figshare · doi:10.6084/m9.figshare.26714287
Hu, Q., Shi, M., Li, Y., & Zhao, X. (2024) · Figshare · doi:10.6084/m9.figshare.26744834
Dark, H. E., An, Y., Duggan, M. R., Joynes, C. M., Davatzikos, C. A., Erus, G., Lewis, A., Moghekar, A. R., Resnick, S. M., & Walker, K. A. (2024) · Figshare · doi:10.6084/m9.figshare.26714284
Genetic architecture of Alzheimer’s disease-related plasma biomarkersPreprint
Aaltonen, A., Palviainen, T., Heikkinen, S., Herukka, S., Hiltunen, M., Kokkola, T., Kärkkäinen, S., FinnGen, Palotie, A. V., Runz, H., et al. (2025) · medRxiv · doi:10.64898/2025.12.17.25342458
Perera‐Cruz, O., Solé‐Padullés, C., Mulet‐Pons, L., Cabello‐Toscano, M. R., Morse, R. M., Abellaneda‐Pérez, K., Perellón‐Alfonso, R., Cattaneo, G., Sánchez, J. S., Alviarez‐Schulze, V., et al. (2026) · Brain Communications · doi:10.1093/braincomms/fcaf511
Liquid crystal biosensing platform based on whispering gallery mode laser for Aβ42 detection
An, P., Li, M., Zhang, S., Lian, D., Li, C., Wang, C., Yu, M., Wang, D., Kong, L., Ren, J., et al. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115985
Fan, J.-D., Fu, Y., Li, Q., Zhang, Z.-Q., Zhao, Y., Hao, Q., Tan, L., Tan, M., & Initiative, T. A. D. N. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1875646
Traub, J., Frey, A., Homola, G. A., Morbach, C., Frantz, S., Pham, M., Störk, S., Stoll, G., Otto, M., & Oeckl, P. (2026) · ESC Heart Failure · doi:10.1093/eschf/xvag202
Genetic architecture of Alzheimer’s disease-related plasma biomarkers
Aaltonen, A., Palviainen, T., Heikkinen, S., Herukka, S.-K., Hiltunen, M. O., Kokkola, T., Kärkkäinen, S., Palotie, A. V., Runz, H., Julkunen, V., et al. (2026) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2026.07.010
Mulligan, M. D., Wang, R., Yang, Q., Beiser, A., Maillard, P., Satizábal, C. L., Ghosh, S., Tanner, J. A., Johnson, K. A., DeCarli, C. S., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261480733
Lee, J. H., Won, G. H., Lee, S.-I., Shin, C.-J., Son, J.-W., Kim, S., Ju, G., Chung, S., Jung, J. H., & Initiative, A. D. N. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261481063
Kim, K. Y., Shin, K. Y., & Chang, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198574
- Authors
- Rauchmann, B. S., Schneider-Axmann, T., & Perneczky, R.
- Affiliations
- LMU Klinikum (DE)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Perneczky, Robert
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2021-06-29
- Volume
- 92
- Issue
- 12
- Pages
- 1289-1295
- ISSN
- 0022-3050 (ISSN-L)
- 1468-330X
- PMC
- PMC8606440
- OpenAlex
- W3176722257
- Cited by
- 74
- References
- 29
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 21 · 2023: 13 · 2022: 12 · 2021: 2
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion, cc-by-nc)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- National Institute on Aging (no Grant / Award Number)
- Johnson & Johnson Pharmaceutical Research & Development (no Grant / Award Number)
- Lumosity (no Grant / Award Number)
- GE Healthcare (no Grant / Award Number)
- IXICO (no Grant / Award Number)
- Janssen Alzheimer Immunotherapy Research & Development (no Grant / Award Number)
- AbbVie (no grant/award number)
- Meso Scale Diagnostics (no Grant / Award Number)
- NeuroRx Research (no Grant / Award Number)
- Alzheimer’s Association (no grant/award number)
- Alzheimer’s Drug Discovery Foundation (no Grant / Award Number)
- Araclon Biotech (no Grant / Award Number)
- Neurotrack Technologies (no Grant / Award Number)
- BioClinica (no Grant / Award Number)
- Novartis Pharmaceuticals Corporation (no Grant / Award Number)
- Lundbeck (no Grant / Award Number)
- Merck (no Grant / Award Number)
- National Institute of Biomedical Imaging and Bioengineering (no Grant / Award Number)
- Transition Therapeutics (no Grant / Award Number)
- The Canadian Institutes of Health Research (no Grant / Award Number)
- Eisai Korea (no Grant / Award Number)
- Elan Pharmaceuticals (no Grant / Award Number)
- U.S. Department of Defense (W81XWH-12-2-0012)
- National Institutes of Health (Grant U01 AG024904)
- Biogen (no Grant / Award Number)
- Pfizer (no Grant / Award Number)
- Bristol-Myers Squibb (no Grant / Award Number)
- Piramal Imaging (no Grant / Award Number)
- Servier (no Grant / Award Number)
- CereSpir, Inc (no Grant / Award Number)
- Takeda Pharmaceutical Company (no Grant / Award Number)
- Cogstate (no Grant / Award Number)
- F. Hoffmann-La Roche (no Grant / Award Number)
- Genentech (no Grant / Award Number)
- Fujirebio US (no Grant / Award Number)
- Eli Lilly and Company (no Grant / Award Number)
- EuroImmun (no Grant / Award Number)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- phosphorylated tau 181, neurofilament light chain, plasma biomarkers, Alzheimer's disease, tau PET, amyloid PET, cognitive performance, neurodegeneration, longitudinal biomarker changes, ADNI
- MeSH terms
- Alzheimer Disease, Brain, Cognition, Humans, Phosphorylation, Biomarkers, Databases, Factual, Amyloid beta-Peptides, tau Proteins, Neurofilament Proteins, Positron-Emission Tomography
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