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Cited by 347

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation

Servello, D, Porta, M, Sassi, M, Brambilla, A, Robertson, M M·2008·Journal of Neurology, Neurosurgery & Psychiatry

Abstract

BACKGROUND: There have been several reports of successful deep brain stimulation (DBS) for the treatment of severe Gilles de la Tourette syndrome (GTS). METHOD: 18 cases of GTS who were resistant to at least 6 months of standard and innovative treatments, as well as to psychobehavioural techniques, underwent DBS. DBS was placed bilaterally in the centromedian-parafascicular (CM-Pfc) and ventralis oralis complex of the thalamus. Patients were evaluated after surgery, with immediate and formal assessments at least every 3 months, including "on-off" and "sham off" in the first nine patients. RESULTS: All patients responded well to DBS, although to differing degrees. The duration of follow-up assessments ranged from 3 to 18 months. The comorbid symptoms of obsessive-compulsive behaviour, obsessive-compulsive disorder, self-injurious behaviours, anxiety and premonitory sensations decreased after treatment with DBS. There were no serious permanent adverse effects. CONCLUSIONS: DBS is a useful and safe treatment for severe GTS. The results of ours and previous DBS reports suggest that the CM-Pfc and ventralis oralis complex of the thalamus may be a good DBS target for GTS.

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Metadata

Authors
Servello, D., Porta, M., Sassi, M., Brambilla, A., & Robertson, M. M.
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
2008-02-01
Volume
79
Issue
2
Pages
136-142
ISSN
0022-3050 (ISSN-L)
OpenAlex
W2153046714
Cited by
347
References
4
FWCI
32.56
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. https://app.cochat.ai/papers/10.1136/jnnp.2006.104067
The paper
Servello, D., Porta, M., Sassi, M., Brambilla, A., & Robertson, M. M. (2008). Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.2006.104067

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