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Cited by 183Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Depression and anxiety related subtypes in Parkinson's disease

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Brown, R. G., Landau, S., Hindle, J. V., Playfer, J., Samuel, M., Wilson, K. C., Hurt, C. S., Anderson, R. J., Carnell, J., Dickinson, L., Gibson, G., van Schaick, R., Sellwood, K., Thomas, B. A., Burn, D. J., for the PROMS-PD Study Group·2011·Journal of Neurology, Neurosurgery & Psychiatry
DOI 10.1136/jnnp.2010.213652
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Abstract

BACKGROUND: Depression and anxiety are common in Parkinson's disease (PD) and although clinically important remain poorly understood and managed. To date, research has tended to treat depression and anxiety as distinct phenomena. There is growing evidence for heterogeneity in PD in the motor and cognitive domains, with implications for pathophysiology and outcome. Similar heterogeneity may exist in the domain of depression and anxiety. OBJECTIVE: To identify the main anxiety and depression related subtype(s) in PD and their associated demographic and clinical features. METHODS: A sample of 513 patients with PD received a detailed assessment of depression and anxiety related symptomatology. Latent Class Analysis (LCA) was used to identify putative depression and anxiety related subtypes. Results LCA identified four classes, two interpretable as 'anxiety related': one anxiety alone (22.0%) and the other anxiety coexisting with prominent depressive symptoms (8.6%). A third subtype (9%) showed a prominent depressive profile only without significant anxiety. The final class (60.4%) showed a low probability of prominent affective symptoms. The validity of the four classes was supported by distinct patterns of association with important demographic and clinical variables. CONCLUSION: Depression in PD may manifest in two clinical phenotypes, one 'anxious-depressed' and the other 'depressed'. However, a further large proportion of patients can have relatively isolated anxiety. Further study of these putative phenotypes may identify important differences in pathophysiology and other aetiologically important factors and focus research on developing more targeted and effective treatment.

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Authors
Brown, R. G., Landau, S., Hindle, J. V., Playfer, J., Samuel, M., Wilson, K. C., Hurt, C. S., Anderson, R. J., Carnell, J., Dickinson, L., Gibson, G., van Schaick, R., Sellwood, K., Thomas, B. A., Burn, D. J., & for the PROMS-PD Study Group
Affiliations
  • King's College London (GB)
  • Betsi Cadwaladr University Health Board (GB)
  • University of Liverpool (GB)
  • East Kent Hospitals University NHS Foundation Trust (GB)
  • Newcastle University (GB)
  • University of Newcastle Australia (AU)
Corresponding author
Brown, R. G.
ORCID
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
2011-01-08
Volume
82
Issue
7
Pages
803-809
ISSN
0022-3050 (ISSN-L)
DOI
10.1136/jnnp.2010.213652
OpenAlex
W2098148677
Cited by
183
References
45
Citations by year
2026: 4 · 2025: 11 · 2024: 13 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 15 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 19 · 2015: 13 · 2014: 12 · 2013: 16 · 2012: 13
FWCI
9.94
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
  • Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
  • Research Portal (King's College London) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
Parkinson's UK (J-0601)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
Parkinson's disease, depression, anxiety, depressive phenotype, psychiatric comorbidity, latent class analysis, clinical phenotype
MeSH terms
Aged, Anxiety, Cognition Disorders, Depression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease, Predictive Value of Tests, Psychiatric Status Rating Scales, Socioeconomic Factors, Reproducibility of Results, Multivariate Analysis, Cluster Analysis, Logistic Models

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