Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease
Open accessAbstract
Anxiety disorders are common in Parkinson's disease (PD), but are not well characterized. This study determined the prevalence and clinical correlates of all DSM‐IV‐TR anxiety disorder diagnoses in a sample of 127 subjects with idiopathic PD who underwent comprehensive assessments administered by a psychiatrist and neurologist. A panel of six psychiatrists with expertise in geriatric psychiatry and/or movement disorders established by consensus all psychiatric diagnoses. Current and lifetime prevalence of at least one anxiety disorder diagnosis was 43% (n = 55) and 49% (n = 63), respectively. Anxiety disorder not otherwise specified, a DSM diagnosis used for anxiety disturbances not meeting criteria for defined subtypes, was the most common diagnosis (30% lifetime prevalence, n = 38). Compared with nonanxious subjects, panic disorder (n = 13) was associated with earlier age of PD onset [50.3 (12.2) vs. 61.0 (13.7) years, P < 0.01], higher rates of motor fluctuations [77% (10/13) vs. 39% (25/64), P = 0.01] and morning dystonia [38% (5/13) vs. 13% (8/62), P < 0.03]. This high prevalence of anxiety disorders, including disturbances often not meeting conventional diagnostic criteria, suggests that anxiety in PD is likely underdiagnosed and undertreated and refined characterization of anxiety disorders in PD is needed. In addition, certain anxiety subtypes may be clinically useful markers associated with disease impact in PD. © 2009 Movement Disorder Society
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Anxiety and depression are frequently seen non-motor symptoms in Parkinson's disease.
“Anxiety and depression are common non-motor symptoms of Parkinson’s disease (PD).”
From Online Mindfulness-Based Cognitive Therapy for People with Parkinson’s Disease and Their Caregivers: a Pilot Study (2022) · cites this paper as Pontone et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391 · see citing works
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069 · see citing works
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works
Stages in the development of Parkinson’s disease-related pathology
Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689 · see citing works
Recent developments in Parkinson's disease
Fahn, S., Elton, R., MARSDEN, C. D., Calne, D. B., & Goldstein, M. (1986) · Raven Press eBooks · Cited by 2,306 · see citing works
Parkinsonism: Onset, progression, and mortality
Hoehn, M., & Yahr, M. (2011) · Neurology · doi:10.1212/01.wnl.0000405146.06300.91 · Cited by 1,888 · see citing works
A Review and Meta-Analysis of the Genetic Epidemiology of Anxiety Disorders
Hettema, J. M., Neale, M. C., & Kendler, K. S. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1568 · Cited by 1,563 · see citing works
Best Estimate of Lifetime Psychiatric Diagnosis
Leckman, J. F. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290080001001 · Cited by 1,418 · see citing works
Hoehn, M. M. M., & Yahr, M. D. (1998) · Neurology · doi:10.1212/wnl.50.2.318 · Cited by 873 · see citing works
Nonmotor fluctuations in Parkinson’s disease: Frequent and disabling
Witjas, T., Kaphan, E., Azulay, J. P., Blin, O., Ceccaldi, M., Pouget, J., Poncet, M., & Chérif, A. A. (2002) · Neurology · doi:10.1212/wnl.59.3.408 · Cited by 642 · see citing works
Excessive Daytime Sleepiness and Sudden-Onset Sleep in Parkinson Disease
Hobson, D. E., Lang, A. E., Martin, W. R. W., Razmy, A., Rivest, J., & Fleming, J. A. E. (2002) · JAMA · doi:10.1001/jama.287.4.455 · Cited by 552 · see citing works
The prevalence of anxiety in older adults: Methodological issues and a review of the literature
Bryant, C., Jackson, H., & Ames, D. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.11.008 · Cited by 511 · see citing works
Parkin disease: a phenotypic study of a large case series
Khan, N. L., Graham, E., Critchley, P., Schrag, A. E., Wood, N. W., Lees, A. J., Bhatia, K. P., & Quinn, N. P. (2003) · Brain · doi:10.1093/brain/awg142 · Cited by 352 · see citing works
Khan, N. L., Jain, S., Lynch, J. M., Pavese, N., Abou‐Sleiman, P. M., Holton, J. L., Healy, D. G., Gilks, W. P., Sweeney, M. G., Ganguly, M., et al. (2005) · Brain · doi:10.1093/brain/awh667 · Cited by 317 · see citing works
Parkinson's disease and anxiety: Comorbidity with depression
Menza, M. A., Robertson-Hoffman, D. E., & Bonapace, A. S. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90237-8 · Cited by 316 · see citing works
Anxiety disorders in patients with Parkinson's disease
Stein, M. B., Heuser, I. J. E., Juncos, J. L., & Uhde, T. W. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.2.217 · Cited by 289 · see citing works
Anxiety rating scales in Parkinson's disease: Critique and recommendations
Leentjens, A. F. G., Dujardin, K., Marsh, L., Martínez‐Martín, P., Richard, I. H., STARKSTEIN, S. E., Weintraub, D. A., Sampaio, C., Poewe, W. H., Rascol, O., et al. (2008) · Movement Disorders · doi:10.1002/mds.22233 · Cited by 275 · see citing works
Self-citationThe role of the locus coeruleus in the development of Parkinson's disease
Gesi, M., Soldani, P., Giorgi, F. S., Santinami, A., Bonaccorsi, I., & Fornai, F. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00028-2 · Cited by 254 · see citing works
Sullivan, G., Coplan, J., Kent, J., & Gorman, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00246-2 · Cited by 245 · see citing works
Psychiatric comorbidity in a population of Parkinson's disease patients
Nuti, A., Ceravolo, R., Piccinni, A., Dell’Agnello, G., Bellini, G., Gambaccini, G., Rossi, C. A., Logi, C., Dell’Osso, L., & Bonuccelli, U. (2004) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00781.x · Cited by 199 · see citing works
McKinlay, A., Grace, R. C., Dalrymple‐Alford, J. C., Anderson, T., Fink, J., & Roger, D. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.05.009 · Cited by 164 · see citing works
Prospective study of phobic anxiety and risk of Parkinson's disease
Weisskopf, M. G., Chen, H., Schwarzschild, M. A., Kawachi, I. I., & Ascherio, A. (2003) · Movement Disorders · doi:10.1002/mds.10425 · Cited by 145 · see citing works
Preliminary examination of the comorbidity of anxiety and depression in Parkinson's disease
Henderson, R., Kurlan, R., Kersun, J. M., & Como, P. G. (1992) · Journal of Neuropsychiatry · doi:10.1176/jnp.4.3.257 · Cited by 133 · see citing works
Evidence for atypical depression in Parkinson's disease
Schiffer, R. B., Kurlan, R., Rubin, A., & Boer, S. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.8.1020 · Cited by 127 · see citing works
Carod-Artal, F. J., Ziomkowski, S., Mesquita, H., & Martínez‐Martín, P. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.06.011 · Cited by 121 · see citing works
Anxiety and motor performance in parkinson's disease
Siemers, E., Shekhar, A., Quaid, K. A., & Dickson, H. (1993) · Movement Disorders · doi:10.1002/mds.870080415 · Cited by 107 · see citing works
Noradrenaline in Parkinsons Disease: From Disease Progression to Current Therapeutics
Fornai, F., di Poggio, A. B., Pellegrini, A., Ruggieri, S. A., & Paparelli, A. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707781745550 · Cited by 103 · see citing works
Maricle, R. A., Nutt, J. G., & Carter, J. H. (1995) · Movement Disorders · doi:10.1002/mds.870100316 · Cited by 88 · see citing works
Differential DSM-III Psychiatric Disorder Prevalence Profiles in Dystonia and Parkinson's Disease
Lauterbach, E. C., Freeman, A., & Vogel, R. L. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.1.29 · Cited by 78 · see citing works
Increased Risk of Depressive and Anxiety Disorders in Relatives of Patients With Parkinson Disease
Arabia, G., Grossardt, B. R., Geda, Y. E., Carlin, J. M., Bower, J. H., Ahlskog, J. E., Maraganore, D. M., & Rocca, W. A. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.12.1385 · Cited by 69 · see citing works
Anxiety disorders in familial parkinsonism
Bacher, N. M., & Ruskin, P. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.2.274b · Cited by 67 · see citing works
Kümmer, A., Cardoso, F., & Teixeira, A. L. (2008) · Movement Disorders · doi:10.1002/mds.22221 · Cited by 60 · see citing works
Validation of PDQ-8 as an independent instrument in English and Chinese
Tan, L. C. S., Lau, P., Au, W., & Luo, N. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.072 · Cited by 51 · see citing works
Prevalence of Social Phobia in Non-Demented Elderly From a Swedish Population Study
Karlsson, B., Klenfeldt, I. F., Sigström, R., Wærn, M., Östling, S., Gustafson, D., & Skoog, I. G. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181860051 · Cited by 46 · see citing works
Parkinson's disease: a preliminary study of yohimbine challenge in patients with anxiety.
Richard, I., Szegethy, E., Lichter, D. G., Schiffer, R. B., & Kurlan, R. (1999) · PubMed · Cited by 22 · see citing works
The locus ceruleus and anxiety disorders in demented and nondemented familial parkinsonism
Lauterbach, E. C. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.6.994a · Cited by 16 · see citing works
Clinical Implications of Parkinson's Disease Genetics
Lorincz, M. (2006) · Seminars in Neurology · doi:10.1055/s-2006-951621 · Cited by 15 · see citing works
Parkinson's Disease Following Panic Disorder
Matsui, H., Udaka, F., Oda, M., Tamura, A., Kubori, T., Nishinaka, K., & Kameyama, M. (2006) · Journal of Neuropsychiatry · doi:10.1176/jnp.18.1.130 · Cited by 5 · see citing works
Correlation of Parkinson's disease severity and duration with123I-FP-CIT SPECT striatal uptake
Benamer, H. T. S., Patterson, J., Wyper, D. J., Hadley, D. M., Macphee, G. J. A., & Grosset, D. G. (2000) · Movement Disorders · doi:10.1002/1531-8257(200007)15:4
Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [13]First MB Spitzer RL Gibbon M Williams J Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P) Biometrics Research 2002 New York State Psychiatric Institute November 2002
Cited by
Sorted by citations
Anxiety disorders in older adults: a comprehensive review
Wolitzky-Taylor, K. B., Castriotta, N., Lenze, E. J., Stanley, M. A., & Craske, M. G. (2010) · Depression and Anxiety · doi:10.1002/da.20653 · Cited by 726 · see citing works
Circuit Mechanisms of Parkinson’s Disease
McGregor, M. M., & Nelson, A. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.004 · Cited by 632 · see citing works
Prevalence of anxiety in Parkinson's disease: A systematic review and meta‐analysis
Broen, M. P. G., Narayen, N. E., Kuijf, M. L., Dissanayaka, N. N. W., & Leentjens, A. F. G. (2016) · Movement Disorders · doi:10.1002/mds.26643 · Cited by 457 · see citing works
Parkinson's disease: The quintessential neuropsychiatric disorder
Weintraub, D. A., & Burn, D. J. (2011) · Movement Disorders · doi:10.1002/mds.23664 · Cited by 422 · see citing works
The Parkinson Anxiety Scale (PAS): Development and validation of a new anxiety scale
Leentjens, A. F. G., Dujardin, K., Pontone, G. M., Starkstein, S. E., Weintraub, D., & Martinez‐Martin, P. (2014) · Movement Disorders · doi:10.1002/mds.25919 · Cited by 270 · see citing works
Self-citationHomeostasis and metabolism of iron and other metal ions in neurodegenerative diseases
Chen, L., Shen, Q., Liu, Y., Zhang, Y., Sun, L., Ma, X., Song, N., & Xie, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02071-0 · Cited by 271 · see citing works
Leentjens, A. F. G., Dujardin, K., Marsh, L., Richard, I. H., STARKSTEIN, S. E., & Martínez‐Martín, P. (2011) · Movement Disorders · doi:10.1002/mds.23184 · Cited by 224 · see citing works
Self-citationPsychosis, apathy, depression and anxiety in Parkinson's disease
Gallagher, D. A., & Schrag, A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.041 · Cited by 211 · see citing works
van Uem, J. M. T., Marinus, J., Canning, C. G., van Lummel, R. C., Dodel, R. C., Liepelt‐Scarfone, I., Berg, D., Morris, M. E., & Maetzler, W. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.014 · Cited by 207 · see citing works
Depression and anxiety related subtypes in Parkinson's disease
Brown, R. G., Landau, S., Hindle, J. V., Playfer, J., Samuel, M., Wilson, K. C., Hurt, C. S., Anderson, R. J., Carnell, J., Dickinson, L., et al. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.213652 · Cited by 183 · see citing works
Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies
Wen, M., Chan, L. L., Tan, L. C. S., & Tan, E. (2016) · European Journal of Neurology · doi:10.1111/ene.13002 · Cited by 183 · see citing works
Symptomatology and markers of anxiety disorders in Parkinson's disease: A cross‐sectional study
Leentjens, A. F. G., Dujardin, K., Marsh, L., Martinez‐Martin, P., Richard, I. H., & Starkstein, S. E. (2011) · Movement Disorders · doi:10.1002/mds.23528 · Cited by 173 · see citing works
Self-citationPrange, S., Klinger, H., Laurencin, C., Danaila, T., & Thobois, S. (2022) · Drugs & Aging · doi:10.1007/s40266-022-00942-1 · Cited by 183 · see citing works
The Neuropsychiatry of Parkinson Disease: A Perfect Storm
Weintraub, D. A., & Mamikonyan, E. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.03.002 · Cited by 164 · see citing works
Exercise and Parkinson's disease
Xu, X., Fu, Z., & Le, W. (2019) · International Review of Neurobiology · doi:10.1016/bs.irn.2019.06.003 · Cited by 158 · see citing works
Parkinson's disease motor subtypes and mood
Burn, D. J., Landau, S., Hindle, J. V., Samuel, M., Wilson, K., Hurt, C. S., Brown, R. G., & for the PROMS‐PD Study Group (2011) · Movement Disorders · doi:10.1002/mds.24041 · Cited by 149 · see citing works
Awareness and current knowledge of Parkinson’s disease: a neurodegenerative disorder
Khan, A. U., Akram, M., Daniyal, M., & Zainab, R. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1486837 · Cited by 145 · see citing works
Reynolds, G., Otto, M. W., Ellis, T. D., & Cronin‐Golomb, A. (2015) · Movement Disorders · doi:10.1002/mds.26484 · Cited by 132 · see citing works
Jaunarajs, K. L. E., Angoa‐Pérez, M., Kuhn, D. M., & Bishop, C. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.007 · Cited by 129 · see citing works
Main, A. S. D., Gallo, J. J., & Pontone, G. M. (2014) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.03.020 · Cited by 129 · see citing works
Self-citationPrevalence of malnutrition in Parkinson's disease: a systematic review
Sheard, J. M., Ash, S., Silburn, P. A., & Kerr, G. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00413.x · Cited by 128 · see citing works
The clinical spectrum of anxiety in Parkinson's disease
Dissanayaka, N. N. N. W., White, E., O'Sullivan, J. D., Marsh, R., Pachana, N. A., & Byrne, G. J. (2014) · Movement Disorders · doi:10.1002/mds.25937 · Cited by 124 · see citing works
Parkinson’s Disease as a Disconnection Syndrome
Cronin‐Golomb, A. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9128-8 · Cited by 118 · see citing works
van der Velden, R. M. J., Broen, M. P. G., Kuijf, M. L., & Leentjens, A. F. G. (2018) · Movement Disorders · doi:10.1002/mds.27465 · Cited by 118 · see citing works
Psychiatric aspects of Parkinson’s disease
Grover, S., Somaiya, M. P., Kumar, S., & Avasthi, A. (2014) · Journal of Neurosciences in Rural Practice · doi:10.4103/0976-3147.143197 · Cited by 113 · see citing works
Westheimer, O., McRae, C., Henchcliffe, C., Fesharaki‐Zadeh, A., Glazman, S., Ene, H., & Bodis-Wollner, I. G. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1380-x · Cited by 115 · see citing works
Ferreira, R. M., Alves, W. M. G. D. C., de Lima, T. A., Alves, T. G. G., Filho, P. A. M. A., Pimentel, C. P., de Sousa, E. C., & Cortinhas‐Alves, E. A. (2018) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20180071 · Cited by 114 · see citing works
International validation of a behavioral scale in Parkinson's disease without dementia
Rieu, I., Martínez‐Martín, P., Pereira, B., de Chazeron, I., Metman, L. V., Jahanshahi, M., Ardouin, C., Chéreau, I., Brefel‐Courbon, C., Ory‐Magne, F., et al. (2015) · Movement Disorders · doi:10.1002/mds.26223 · Cited by 112 · see citing works
Neurobiology of Depression and Anxiety in Parkinson's Disease
Kano, O., Ikeda, K., Cridebring, D., Takazawa, T., Yoshii, Y., & Iwasaki, Y. (2011) · Parkinson s Disease · doi:10.4061/2011/143547 · Cited by 107 · see citing works
Emotional manifestations of PD: Neurobiological basis
Castrioto, A., Thobois, S., Carnicella, S., Maillet, A., & Krack, P. (2016) · Movement Disorders · doi:10.1002/mds.26587 · Cited by 98 · see citing works
Huang, C. C., Ravdin, L., Nirenberg, M. J., Piboolnurak, P., Severt, L., Maniscalco, J. S., Sólnes, L. B., Dorfman, B. J., & Henchcliffe, C. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000345987 · Cited by 99 · see citing works
Anxiety and motor fluctuations in Parkinson's disease: A cross-sectional observational study
Leentjens, A. F. G., Dujardin, K., Marsh, L., Martínez‐Martín, P., Richard, I., & STARKSTEIN, S. E. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.06.007 · Cited by 97 · see citing works
Self-citationDong, J., Hawes, S., Wu, J., Le, W., & Cai, H. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.645287 · Cited by 94 · see citing works
Management of psychiatric and cognitive complications in Parkinson’s disease
Weintraub, D. A., Aarsland, D., Biundo, R., Dobkin, R. D., Goldman, J. G., & Lewis, S. J. G. (2022) · BMJ · doi:10.1136/bmj-2021-068718 · Cited by 91 · see citing works
Martens, K. A. E., Hall, J. M., Gilat, M., Georgiades, M., Walton, C. C., & Lewis, S. J. G. (2016) · Gait & Posture · doi:10.1016/j.gaitpost.2016.07.182 · Cited by 90 · see citing works
Impact of Anxiety on Quality of Life in Parkinson's Disease
Hanna, K. K., & Cronin‐Golomb, A. (2011) · Parkinson s Disease · doi:10.1155/2012/640707 · Cited by 89 · see citing works
Epigenome-Wide Association Study for Parkinson’s Disease
Moore, K., McKnight, A. J., Craig, D., & O’Neill, F. A. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8332-8 · Cited by 87 · see citing works
Foyet, H. S., Hriţcu, L., Ciobica, A. S., Ștefan, M., Kamtchouing, P., & Cojocaru, D. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.11.011 · Cited by 84 · see citing works
Emotional dysfunction in Parkinson's disease.
Blonder, L. X., & Slevin, J. T. (2011) · PubMed Central · doi:10.3233/ben-2011-0329 · Cited by 83 · see citing works
Bian, Y., Zhao, C., & Lee, S. M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.579052 · Cited by 83 · see citing works
Šumec, R., Filip, P., Sheardová, K., & Bareš, M. (2015) · Behavioural Neurology · doi:10.1155/2015/620674 · Cited by 82 · see citing works
Mack, J. M., Schamne, M. G., Sampaio, T. B., Pértile, R. A. N., Fernandes, P. A. C. M., Markus, R. P., & Prediger, R. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3472032 · Cited by 82 · see citing works
Emotional Dysfunction in Parkinson’s Disease
Blonder, L. X., & Slevin, J. T. (2011) · Behavioural Neurology · doi:10.1155/2011/143857 · Cited by 89 · see citing works
Zhang, Q., Hu, J., Wei, L., Jia, Y., & Jin, Y. (2019) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2019.04.005 · Cited by 80 · see citing works
Calleo, J. S., Amspoker, A. B., Sarwar, A. I., Kunik, M. E., Jankovic, J., Marsh, L., York, M., & Stanley, M. A. (2015) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988715588831 · Cited by 71 · see citing works
Self-citationMood disorders in Parkinson's disease
Tan, L. C. S. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70024-4 · Cited by 70 · see citing works
Anxiety in Parkinson's disease: Symptom dimensions and overlap with depression and autonomic failure
Rutten, S., Ghielen, I., Vriend, C., Hoogendoorn, A. W., Berendse, H. W., Leentjens, A. F. G., van der Werf, Y. D., Smit, J. H., & van den Heuvel, O. A. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.11.019 · Cited by 73 · see citing works
Anxiety and self-perceived health status in Parkinson’s disease
Pontone, G. M., Williams, J. R., Anderson, K. E., Chase, G. A., Goldstein, S. R., Grill, S. E., Hirsch, E. S., Lehmann, S. W., Little, J. T., Margolis, R. L., et al. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.01.005 · Cited by 67 · see citing works
Self-citationCrowley, E. K., Nolan, Y. M., & Sullivan, A. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.11.003 · Cited by 65 · see citing works
Depression and anxiety in Parkinson disease
Martínez‐Martín, P., & Damián, J. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.49 · Cited by 64 · see citing works
Pontone, G. M., Dissanayaka, N. N., Apostolova, L. G., Brown, R. G., Dobkin, R. D., Dujardin, K., Friedman, J. H., Leentjens, A. F. G., Lenze, E. J., Marsh, L., et al. (2019) · npj Parkinson s Disease · doi:10.1038/s41531-019-0102-8 · Cited by 63 · see citing works
Self-citationAffective symptoms and cognitive functions in Parkinson's disease
Poletti, M., Rosa, A. D., & Bonuccelli, U. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.02.022 · Cited by 62 · see citing works
A meta-analysis of third wave mindfulness-based cognitive behavioral therapies for older people
Kishita, N., Takei, Y., & Stewart, I. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4621 · Cited by 60 · see citing works
Disease-specific anxiety symptomatology in Parkinson's disease
Dissanayaka, N. N., O’Sullivan, J. D., Pachana, N. A., Marsh, R., Silburn, P. A., White, E., Torbey, E., Mellick, G. D., Copland, D. A., & Byrne, G. J. (2016) · International Psychogeriatrics · doi:10.1017/s1041610215002410 · Cited by 59 · see citing works
Validity and reliability of the Geriatric Anxiety Inventory in Parkinson's disease*†
Matheson, S., Byrne, G. J., Dissanayaka, N. N., Pachana, N. A., Mellick, G. D., O’Sullivan, J. D., Silburn, P. A., Sellbach, A. N., & Marsh, R. (2010) · Australian Journal on Ageing · doi:10.1111/j.1741-6612.2010.00487.x · Cited by 58 · see citing works
Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study.
Pirogovsky-Turk, E., Moore, R. C., Filoteo, J., Litvan, I., Song, D., Lessig, S., & Schiehser, D. (2017) · The American journal of geriatric psychiatry · doi:10.1016/j.jagp.2016.10.004 · Cited by 52 · see citing works
Purri, R., Brennan, L., Rick, J. H., Xie, S. X., Deck, B. L., Chahine, L. M., Dahodwala, N. A., Chen‐Plotkin, A. S., Duda, J. E., Morley, J. F., et al. (2020) · Movement Disorders · doi:10.1002/mds.28115 · Cited by 57 · see citing works
Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders
Patterson, L., Rushton, S., Attems, J., Thomas, A. J., & Morris, C. M. (2018) · Brain Pathology · doi:10.1111/bpa.12697 · Cited by 52 · see citing works
Anxiety Disorders: Differential Diagnosis and Their Relationship to Chronic Pain
Jordan, K. D., & Okifuji, A. (2011) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2011.596922 · Cited by 51 · see citing works
Dujardin, K., & Sgambato, V. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00025 · Cited by 46 · see citing works
Increased dopamine transporter density in Parkinson's disease patients with social anxiety disorder
Moriyama, T. S., Felicio, A. C., Chagas, M. H. N., Tardelli, V. S., Ferraz, H. B., Tumas, V., Amaro, E., Andrade, L. E. C., Crippa, J. A. S., & Bressan, R. A. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.06.056 · Cited by 50 · see citing works
Alhusaini, M., Eissa, N., Saad, A. K., Beiram, R., & Sadek, B. S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.861094 · Cited by 49 · see citing works
Metabotropic Glutamate Receptors in Central Nervous System Diseases
Golubeva, A. V., Moloney, R. D., O’Connor, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Current Drug Targets · doi:10.2174/1389450116666150316224011 · Cited by 49 · see citing works
Beserra‐Filho, J. I. A., Macedo, A. M. D. [., Leão, A. H. F. F., Bispo, J. M. M., dos Santos, J. R., Melo, A. J. D. O., Menezes, P. D. P., Duarte, M. C., Araújo, A. A. D. S., Silva, R. H., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.11.056 · Cited by 49 · see citing works
Anxiety and Depression in Parkinson’s Disease
Djamshidian, A., & Friedman, J. H. (2014) · Current Treatment Options in Neurology · doi:10.1007/s11940-014-0285-6 · Cited by 47 · see citing works
Neuropsychiatric symptoms in untreated Parkinson’s disease
Szatmári, S., Illigens, B. M. W., Siepmann, T., Pintér, A., Takáts, A., & Bereczki, D. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s130997 · Cited by 47 · see citing works
Stuckenschneider, T., Askew, C. D., Menêses, A. L., Baake, R., Weber, J., & Schneider, S. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-181484 · Cited by 45 · see citing works
The relation of anxiety and cognition in Parkinson’s disease.
Reynolds, G., Hanna, K. K., Neargarder, S. A., & Cronin‐Golomb, A. (2017) · Neuropsychology · doi:10.1037/neu0000353 · Cited by 44 · see citing works
Clinical Markers of Anxiety Subtypes in Parkinson Disease
Broen, M. P. G., Leentjens, A. F. G., Hinkle, J. T., Moonen, A. J. H., Kuijf, M. L., Fischer, N. M., Perepezko, K. M., Bakker, A., & Pontone, G. M. (2018) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988718757369 · Cited by 44 · see citing works
Self-citationNeurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
Bogdanova, Y., & Cronin‐Golomb, A. (2011) · Parkinson s Disease · doi:10.1155/2012/793076 · Cited by 43 · see citing works
Nonmotor Fluctuations in Parkinson's Disease.
Franke, C., & Storch, A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.021 · Cited by 54 · see citing works
Anxiety Has Specific Syndromal Profiles in Parkinson Disease: A Data-Driven Approach
STARKSTEIN, S. E., Dragović, M., Dujardin, K., Marsh, L., Martínez‐Martín, P., Pontone, G. M., Richard, I. H., Weintraub, D. A., & Leentjens, A. F. G. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.09.006 · Cited by 41 · see citing works
Self-citationNon-motor symptoms in Parkinson's disease: Opening new avenues in treatment
Gupta, S., & Shukla, S. (2021) · Current Research in Behavioral Sciences · doi:10.1016/j.crbeha.2021.100049 · Cited by 41 · see citing works
Management of psychiatric disorders in Parkinson's disease
Weintraub, D. A. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00875-w · Cited by 42 · see citing works
Characteristics and Treatment of Anxiety Disorders in Parkinson's Disease
Dissanayaka, N. N., White, E., O’Sullivan, J. D., Marsh, R., Silburn, P. A., Copland, D. A., Mellick, G. D., & Byrne, G. J. (2015) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12157 · Cited by 39 · see citing works
Qureshi, S. U., Amspoker, A. B., Calleo, J., Kunik, M. E., & Marsh, L. (2012) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988712466458 · Cited by 39 · see citing works
Self-citationCognitive Behavioral Therapy for Depression and Anxiety in Parkinson's Disease: A Clinical Review
Armento, M. E. A., Stanley, M. A., Marsh, L., Kunik, M. E., York, M. K., Bush, A. L., & Calleo, J. S. (2012) · Journal of Parkinson's Disease · doi:10.3233/jpd-2012-12080 · Cited by 49 · see citing works
Self-citationJones, J. D., Kurniadi, N. E., Kuhn, T. P., Szymkowicz, S. M., Bunch, J., & Rahmani, E. (2019) · Neuropsychology · doi:10.1037/neu0000583 · Cited by 38 · see citing works
Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease
Hirao, K., Pontone, G. M., & Smith, G. S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.010 · Cited by 37 · see citing works
Self-citationScreening for Anxiety Symptoms in Parkinson Disease
Stefanova, E. D., Žiropadja, L., Petrovic, M. J., Stojković, T., & Kostić, V. (2013) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988713476368 · Cited by 37 · see citing works
Neuropsychiatric and Cognitive Deficits in Parkinson’s Disease and Their Modeling in Rodents
Decourt, M., Jiménez‐Urbieta, H., Benoit‐Marand, M., & Fernagut, P. (2021) · Biomedicines · doi:10.3390/biomedicines9060684 · Cited by 37 · see citing works
Neuropsychiatric Complications of Parkinson Disease Treatments: Importance of Multidisciplinary Care
Taylor, J., Anderson, W. S., Brandt, J., Mari, Z. K., & Pontone, G. M. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.08.017 · Cited by 36 · see citing works
Self-citationAges at Onset of Anxiety and Depressive Disorders in Parkinson’s Disease
Seritan, A. L., Rienas, C., Duong, T., Delucchi, K., & Ostrem, J. L. (2019) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.18090201 · Cited by 36 · see citing works
Pharmacologic Treatment of Anxiety Disorders in Parkinson Disease
Pontone, G. M., Williams, J. R., Anderson, K. E., Chase, G. A., Goldstein, S. R., Grill, S. E., Hirsch, E. S., Lehmann, S. W., Little, J. T., Margolis, R. L., et al. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.023 · Cited by 36 · see citing works
Self-citationvan der Wee, N. J. A., Wen, M., Kandiah, N., Chander, R. J., Ng, A. Y. T., Au, W. L., & Tan, L. C. S. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.10.021 · Cited by 35 · see citing works
Detecting anxiety in individuals with Parkinson disease
Mele, B., Holroyd-Leduc, J. M., Smith, E. E., Pringsheim, T. M., Ismail, Z., & Goodarzi, Z. (2017) · Neurology · doi:10.1212/wnl.0000000000004771 · Cited by 35 · see citing works
Santangelo, G., Falco, F., D’Iorio, A., Cuoco, S., Raimo, S., Amboni, M., Pellecchia, M. T., Longo, K., Vitale, C., & Barone, P. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.06.008 · Cited by 34 · see citing works
Psychiatric symptoms screening in the early stages of Parkinson’s disease
Bugalho, P., da Silva, J. A., Cargaleiro, I., Serra, M., & Neto, B. M. (2011) · Journal of Neurology · doi:10.1007/s00415-011-6140-8 · Cited by 32 · see citing works
Carrozzino, D., Morberg, B. M., Siri, C., Pezzoli, G., & Bech, P. (2018) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.024 · Cited by 40 · see citing works
Pontone, G. M., Perepezko, K. M., Hinkle, J. T., Gallo, J. J., Grill, S. E., Leoutsakos, J., Mills, K. A., Weiss, H. D., & Mari, Z. K. (2022) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2022.11.002 · Cited by 31 · see citing works
Self-citationYang, H.-J., Ahn, J., Lee, J. S., Lee, W. K., Lee, J., & Kim, Y. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00049 · Cited by 30 · see citing works
Modeling anxiety in Parkinson's disease
Broen, M. P. G., Köhler, S., Moonen, A. J. H., Kuijf, M. L., Dujardin, K., Marsh, L., Richard, I. H., STARKSTEIN, S. E., Martínez‐Martín, P., & Leentjens, A. F. G. (2015) · Movement Disorders · doi:10.1002/mds.26461 · Cited by 31 · see citing works
Self-citationNon-Motor Fluctuations in Parkinson’s Disease: Underdiagnosed Yet Important
Boura, I., Popławska-Domaszewicz, K., Spanaki, C., Chen, R., Urso, D., van Coller, R., Storch, A., & Chaudhuri, К. R. (2024) · Journal of Movement Disorders · doi:10.14802/jmd.24227 · Cited by 30 · see citing works
Hall, J. M., Shine, J. M., O’Callaghan, C., Walton, C. C., Gilat, M., Naismith, S. L., & Lewis, S. J. G. (2015) · Journal of Parkinson s Disease · doi:10.3233/jpd-150581 · Cited by 30 · see citing works
Rasch analysis of anxiety scales in Parkinson's disease
Forjaz, M. J., Martínez‐Martín, P., Dujardin, K., Marsh, L., Richard, I. H., STARKSTEIN, S. E., & Leentjens, A. F. G. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.02.009 · Cited by 30 · see citing works
Self-citationAssociation of restless legs syndrome, pain, and mood disorders in parkinson's disease
Rana, A. Q., Qureshi, A. R., Rahman, L., Jesudasan, A., Hafez, K. K., & Rana, M. A. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2014.994208 · Cited by 29 · see citing works
A clinical overview of non-motor symptoms in Parkinson's Disease.
Modugno, N., Lena, F., Biasio, F. D., Cerrone, G., Ruggieri, S. A., & Fornai, F. (2013) · PubMed · Cited by 29 · see citing works
Hoffmeister, J. D., Kelm‐Nelson, C. A., & Ciucci, M. R. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113514 · Cited by 28 · see citing works
Basal ganglia oscillations as biomarkers for targeting circuit dysfunction in Parkinson's disease
Petersson, P., Kühn, A. A., Neumann, W., & Fuentes, R. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.02.002 · Cited by 27 · see citing works
González-Usigli, H., Ortíz, G. G., Charles‐Niño, C., Mireles-Ramírez, M. A., Pacheco-Moisés, F. P., Torres-Mendoza, B. M., Hernández-Cruz, J. J., Delgado-Lara, D. L. C., & Ramírez-Jirano, L. J. (2023) · Brain Sciences · doi:10.3390/brainsci13030508 · Cited by 27 · see citing works
- Authors
- Pontone, G. M., Williams, J. R., Anderson, K. E., Chase, G., Goldstein, S. A., Grill, S., Hirsch, E. S., Lehmann, S., Little, J. T., Margolis, R. L., Rabins, P. V., Weiss, H. D., & Marsh, L.
- Affiliations
- Johns Hopkins University (US)
- University of Maryland Medical Center (US)
- Pennsylvania State University (US)
- Corresponding author
- Marsh, Laura
- ORCID
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2009-05-07
- Volume
- 24
- Issue
- 9
- Pages
- 1333-1338
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC2830642
- OpenAlex
- W2121594879
- Cited by
- 305
- References
- 41
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 8 · 2023: 9 · 2022: 15 · 2021: 19 · 2020: 45 · 2019: 20 · 2018: 15 · 2017: 11 · 2016: 27 · 2015: 14 · 2014: 22 · 2013: 25 · 2012: 14
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01-MH069666)
- Morris K. Udall Parkinson's Disease Research Center of Excellence at Johns Hopkins (NIH-P50-NS-58377)
- Age-Related Cognitive Disorders Training Grant (NIH-5T32-AG-027668-02)
- Parkinson Study Group Mentored Clinical Research Award
- Donna Jeanne Gault Baumann Fund
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- Parkinson's disease, anxiety disorders, prevalence, panic disorder, anxiety subtypes, motor fluctuations, age of onset, psychiatric comorbidity, underdiagnosis
- MeSH terms
- Aged, Aged, 80 and over, Anxiety, Anxiety Disorders, Female, Humans, Male, Middle Aged, Parkinson Disease, Prevalence, Panic Disorder
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
