Nerve compression injury and increased endoneurial fluid pressure: A “miniature compartment syndrome”
Open accessAbstract
An inflatable miniature cuff was used to apply local compression of 80 mm Hg or 30 mm Hg to a segment of rat sciatic nerve for time periods varying from two to eight hours. The endoneurial fluid pressure was measured by direct micropipette measurement techniques at one or 24 hours after removal of the cuff, and the nerves were subjected to histological analysis. Endoneurial oedema, associated with a four-fold increase in endoneurial fluid pressure, was observed after compression at 80 mm Hg for four hours, and a three-fold increase was found after compression at 30 or 80 mm Hg for eight hours. Such an increase in endoneurial fluid pressure may interfere with intrafascicular capillary flow, and thereby constitute an important pathophysiological mechanism in nerve compression injuries.
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These drawbacks may induce irreversible damage to the nerves and cause serious biological issues, including inflammation, demyelination, axonal degradation, and blood vein compression.
“These drawbacks may induce irreversible damage to the nerves and cause serious biological issues, including inflammation, demyelination, axonal degradation, and blood vein compression (14–17).”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [15]
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“The perineurium forms the socalled ‘blood-nerve barrier’ (BNB), that biologically seals the fascicular environment, regulating protein diffusion and blocking external pathogens thanks to a slightly positive inner pressure [22].”
Background
- Authors
- Lundborg, G., Myers, R., & Powell, H.
- Affiliations
- United States Department of Veterans Affairs (US)
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1983-12-01
- Volume
- 46
- Issue
- 12
- Pages
- 1119-1124
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC491778
- OpenAlex
- W2084298542
- Cited by
- 316
- References
- 30
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 9 · 2023: 11 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 6 · 2013: 10 · 2012: 7
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- nerve compression injury, sciatic nerve, nerve compression, rat model
- MeSH terms
- Animals, Compartment Syndromes, Disease Models, Animal, Edema, Nerve Compression Syndromes, Pressure, Rats, Inbred Strains, Sciatic Nerve, Rats
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