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Treatment of focal dystonias of the hand with botulinum toxin injections.

Open access
Cohen, L G, Hallett, M, Geller, B D, Hochberg, F·1989·Journal of Neurology, Neurosurgery & Psychiatry

Abstract

The effects of botulinum toxin injections have been studied on 19 patients with hand dystonia. The dystonic muscles were identified by clinical examination and EMG findings of localised bursts of muscle activation with fine wire electrodes during the tasks that precipitated the dystonia. Injections into the most active muscles were given to each patient every 2 weeks in increasing doses (up to 20 U the first week, up to 40 U the second week, and up to 80 U the third week) until performance improvement was achieved. Subjective improvement of cramping, pain and/or tension was associated with temporary weakness in injected muscles. Benefit was seen in 16 patients, lasted between 1 and 6 months, and was reproducible.

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Metadata

Authors
Cohen, L. G., Hallett, M., Geller, B. D., & Hochberg, F.
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
1989-03-01
Volume
52
Issue
3
Pages
355-363
ISSN
0022-3050 (ISSN-L)
OpenAlex
W2132205361
Cited by
174
References
0
FWCI
11.40
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Treatment of focal dystonias of the hand with botulinum toxin injections. https://app.cochat.ai/papers/10.1136/jnnp.52.3.355
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Cohen, L. G., Hallett, M., Geller, B. D., & Hochberg, F. (1989). Treatment of focal dystonias of the hand with botulinum toxin injections. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.52.3.355

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.