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Glial swelling following human cerebral contusion: an ultrastructural study
Open accessAbstract
The ultrastructural features of cerebral contusion seen three hours to 11 days after head injury were studied in 18 patients undergoing surgery. Massive astrocytic swelling ("cytotoxic" oedema) was seen three hours to three days after injury, maximal in perivascular foot processes, and compressing some of the underlying capillaries. The tight junctions were not disrupted. Neuronal damage was most marked three to 11 days after injury. The pathophysiological mechanisms leading to oedema formation and neuronal degeneration are discussed.
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“astroglial swelling, which occurs within the first hours after head trauma in humans (Bullock et al., 1991)”
From Evolution of neuronal and astroglial disruption in the peri-contusional cortex of mice revealed by in vivo two-photon imaging (2013) · cites this paper as Bullock et al., 1991
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Metadata
- Authors
- Bullock, R., Maxwell, W. L., Graham, D. I., Teasdale, G. M., & Adams, J. H.
- Affiliations
- Southern General Hospital (GB)
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1991-05-01
- Volume
- 54
- Issue
- 5
- Pages
- 427-434
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC488543
- OpenAlex
- W2066748433
- Semantic Scholar
- c28e5f645c554c0b2380f20e656d8e782adecc0b
- Cited by
- 186
- References
- 23
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 4 · 2013: 7 · 2012: 6
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- cerebral contusion, glial swelling, astrocytic swelling, cytotoxic edema, neurodegeneration, tight junctions, traumatic brain injury, ultrastructure
- MeSH terms
- Adult, Aged, Astrocytes, Brain Concussion, Brain Edema, Humans, Microscopy, Electron, Middle Aged, Neuroglia, Pinocytosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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