Cited by 186Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAcute Ischemic Stroke Management

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Glial swelling following human cerebral contusion: an ultrastructural study

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Bullock, R, Maxwell, W L, Graham, D I, Teasdale, G M, Adams, J H·1991·Journal of Neurology, Neurosurgery & Psychiatry

DOI 10.1136/jnnp.54.5.427PMC PMC488543

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Abstract

The ultrastructural features of cerebral contusion seen three hours to 11 days after head injury were studied in 18 patients undergoing surgery. Massive astrocytic swelling ("cytotoxic" oedema) was seen three hours to three days after injury, maximal in perivascular foot processes, and compressing some of the underlying capillaries. The tight junctions were not disrupted. Neuronal damage was most marked three to 11 days after injury. The pathophysiological mechanisms leading to oedema formation and neuronal degeneration are discussed.

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Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury
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Stem cells for spine surgery
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Osmotherapy for increased intracranial pressure: Comparison between mannitol and glycerol
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Early ischaemia after severe head injury preliminary results in patients with diffuse brain injuries
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Centrifugal Distribution of Regional Cerebral Blood Flow and its Time Course in Traumatic Intracerebral Hematomas
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Permeability of the Blood–Brain Barrier after Traumatic Brain Injury: Radiological Considerations
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Focal Microvascular Occlusion After Acute Subdural Haematoma in the Rat: a Mechanism for Ischaemic Damage and Brain Swelling?
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Focal Brain Injury: Histological Evidence of Delayed Inflammatory Response in a New Rodent Model of Focal Cortical Injury
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The cerebrovascular response to experimental lateral head acceleration
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Aspartate and Glutamate Transport in Acutely and Chronically Ethanol Exposed Neonatal Rat Primary Astrocyte Cultures
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Morphological Characterization of Photochemical Graded Spinal Cord Injury in the Rat
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Ethanol-induced swelling in neonatal rat primary astrocyte cultures
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Authors: Bullock, R., Maxwell, W. L., Graham, D. I., Teasdale, G. M., & Adams, J. H.
Affiliations: Southern General Hospital (GB)
ORCID: Maxwell, W L
Graham, D I
Venue: Journal of Neurology, Neurosurgery & Psychiatry
Publisher: BMJ
Published: 1991-05-01
Volume: 54
Issue: 5
Pages: 427-434
ISSN: 0022-3050 (ISSN-L)
DOI: 10.1136/jnnp.54.5.427
PMC: PMC488543
OpenAlex: W2066748433
Semantic Scholar: c28e5f645c554c0b2380f20e656d8e782adecc0b
Cited by: 186
References: 23
Citations by year: 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 4 · 2013: 7 · 2012: 6
FWCI: 5.77
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: cerebral contusion, glial swelling, astrocytic swelling, cytotoxic edema, neurodegeneration, tight junctions, traumatic brain injury, ultrastructure
MeSH terms: Adult, Aged, Astrocytes, Brain Concussion, Brain Edema, Humans, Microscopy, Electron, Middle Aged, Neuroglia, Pinocytosis

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Glial swelling following human cerebral contusion: an ultrastructural study

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