Diurnal effects of motor activity and fatigue in Parkinson's disease.
Open accessAbstract
Wrist motor activity was monitored continuously in 65 patients with Parkinson's disease (PD) to assess the influence of disease severity and excessive fatigue on the diurnal motor activity pattern. Mildly or moderately affected PD patients had a similar diurnal pattern to that of 68 healthy controls, with a late morning peak; however, mean levels of motor activity were lower. The most severely affected patients showed an overall flattened diurnal pattern. Results refute the existence of end of day deterioration, but instead suggest a "depressed morning start" in the most severely affected patients with PD. Excessive fatigue was not reported at a particular time of day and did not influence the diurnal motor activity pattern.
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Previous studies have identified increased motor and cognitive fatigue in persons with PD.
“Previous studies have identified increased motor (Friedman & Friedman, 1993; van Hilten et al., 1993) and cognitive fatigue (Alves et al., 2004; Dashtipour et al., 2015) in persons with PD.”
From Perception of Physical Demand, Mental Demand, and Performance: A Comparison of Two Voice Interventions for Parkinson's Disease (2022) · cites this paper as van Hilten et al., 1993
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- Authors
- van Hilten, J. J., Hoogland, G., van der Velde, E. A., Middelkoop, H. A., Kerkhof, G. A., & Roos, R. A.
- ORCID
- Hoogland, G
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1993-08-01
- Volume
- 56
- Issue
- 8
- Pages
- 874-877
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1015141
- OpenAlex
- W2165510184
- Cited by
- 105
- References
- 21
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 10 · 2017: 3 · 2016: 10 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, diurnal variation, motor activity, fatigue, wrist kinematics, disease severity, circadian rhythm
- MeSH terms
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Circadian Rhythm, Fatigue, Female, Humans, Male, Middle Aged, Monitoring, Physiologic, Motor Activity, Parkinson Disease
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