Working memory deficits in multiple sclerosis: A controlled study with auditory P600 correlates
Open accessAbstract
BACKGROUND: Recently, the P600 component of event related potentials, a waveform that is conceived to be generated and/or modulated by basal ganglia and cingulate area has been considered an index of the completion of any synchronised operation after target detection, having much in common with working memory operation. Moreover, dysfunction of these brain structures as well as working memory deficits have been implicated in the pathophysiology of multiple sclerosis. The aim of this study was to investigate the patterns of P600 elicited during a working memory test in multiple sclerosis patients compared with healthy controls. METHODS: Twenty two definite, chronic progressive multiple sclerosis patients, with recent exacerbation of their illness, and 20 normal subjects matched for age, sex, and educational level, were studied with a computerised version of the digit span test of Wechsler batteries. Auditory P600 were measured during the anticipatory period of this test. RESULTS: The patient group, as compared with healthy controls, showed significantly reduced latencies of P600 at left frontal areas and reduced P600 amplitudes at left temporoparietal region. Moreover, memory performance of patients was significantly more impaired when compared with healthy controls. CONCLUSIONS: These findings may indicate that multiple sclerosis is associated with abnormal features of the completion of synchronised operation after target detection, as they are reflected by P600 amplitudes and latencies. Dysfunction of this mechanism may contribute to the identification of basic cognitive processes that could account for the cognitive deficits in multiple sclerosis.
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In multiple sclerosis, auditory P600 measures have been examined as correlates of working-memory dysfunction, and later work showed that treatment-related improvement in memory performance was accompanied by altered right frontal and right frontoparietal P600 activity.
“In multiple sclerosis, auditory P600 measures have been examined as correlates of working-memory dysfunction, and later work showed that treatment-related improvement in memory performance was accompanied by altered right frontal and right frontoparietal P600 activity [182,183].”
From Electrophysiological Correlates of Cognitive Dysfunction in Obsessive-Compulsive Disorder (OCD): A Systematic and Mechanistic Review of EEG, ERP, and QEEG Evidence (2026) · cites this paper as [182]
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Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011 · see citing works
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384 · see citing works
The ten-twenty electrode system of the international federation
Jasper, H. H. (1958) · Electroencephalography and Clinical Neurophysiology · Cited by 6,567 · see citing works
Manual for the Wechsler Adult Intelligence Scale.
Wechsler, D. (1955) · Psychological Corp. eBooks · Cited by 4,941 · see citing works
(2001) · doi:10.1017/cbo9780511546396 · Cited by 4,482 · see citing works
Pauli, W., & Band, W. (1959) · American Journal of Physics · doi:10.1119/1.1934936 · Cited by 1,086 · see citing works
Segmentation of brain electrical activity into microstates: model estimation and validation
Pascual-Marqui, R. D., Michel, C. M., & Lehmann, D. (1995) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.391164 · Cited by 991 · see citing works
Cognitive Dysfunction in Early-Onset Multiple Sclerosis
Amato, M. P., Ponziani, G., Siracusa, G., & Sorbi, S. (2001) · Archives of Neurology · doi:10.1001/archneur.58.10.1602 · Cited by 642 · see citing works
Brain imaging of the central executive component of working memory
Collette, F., & Van der Linden, M. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00063-x · Cited by 617 · see citing works
Recent developments in working memory
Baddeley, A. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80145-1 · Cited by 431 · see citing works
Functional Magnetic Resonance Imaging Correlates of Fatigue in Multiple Sclerosis
Filippi, M., Rocca, M. A., Colombo, B., Falini, A., Codella, M., Scotti, G., & Comi, G. (2002) · NeuroImage · doi:10.1006/nimg.2001.1011 · Cited by 378 · see citing works
Spatial analysis of evoked potentials in man—a review
Lehmann, D., & Skrandies, W. (1984) · Progress in Neurobiology · doi:10.1016/0301-0082(84)90003-0 · Cited by 356 · see citing works
Conklin, H. M., Curtis, C. E., Katsanis, J., & Iacono, W. G. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.2.275 · Cited by 282 · see citing works
Electric source imaging of human brain functions
Michel, C. M., Thut, G., Morand, S. M., Khateb, A., Pegna, A. J., de Peralta, R. G., Gonzalez, S., Seeck, M., & Landis, T. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00086-8 · Cited by 244 · see citing works
Camp, S. J., Stevenson, V. L., Thompson, A. J., Miller, D. H., Borrás, C., Auriacombe, S., Brochet, B., Falautano, M., Filippi, M., Herisse-Dulo, L., et al. (1999) · Brain · doi:10.1093/brain/122.7.1341 · Cited by 229 · see citing works
Regional Magnetic Resonance Imaging Lesion Burden and Cognitive Function in Multiple Sclerosis
Sperling, R. A., Guttmann, C. R. G., Hohol, M. J., Warfield, S. K., Jakab, M., Parente, M., Diamond, E. L., Daffner, K. R., Olek, M. J., Orav, E. J., et al. (2001) · Archives of Neurology · doi:10.1001/archneur.58.1.115 · Cited by 219 · see citing works
Falkenstein, M., Hohnsbein, J., & Hoormann, J. (1994) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(94)90055-8 · Cited by 204 · see citing works
Garcı́a-Larrea, L., & Cézanne-Bert, G. (1998) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/s0168-5597(97)00085-3 · Cited by 187 · see citing works
Diversity and plasticity of self recognition during the development of multiple sclerosis.
Tuohy, V. K., Yu, M., Weinstock‐Guttman, B., & Kinkel, R. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119331 · Cited by 164 · see citing works
Language related brain potentials in patients with cortical and subcortical left hemisphere lesions
Friederici, A. D. (1999) · Brain · doi:10.1093/brain/122.6.1033 · Cited by 162 · see citing works
Working Memory in Schizophrenia: Transient "Online" Storage Versus Executive Functioning
Perry, W., Heaton, R. K., Potterat, E. G., Roebuck, T. M., Minassian, A., & BRAFF, D. L. (2001) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006854 · Cited by 155 · see citing works
Bicaudate Ratio as a Magnetic Resonance Imaging Marker of Brain Atrophy in Multiple Sclerosis
Bermel, R. A., Bakshi, R., Tjoa, C. W., Puli, S. R., & Jacobs, L. R. (2002) · Archives of Neurology · doi:10.1001/archneur.59.2.275 · Cited by 148 · see citing works
Brain imaging of human memory systems: between-systems similarities and within-system differences
Nyberg, L. H., Forkstam, C., Petersson, K. M., Cabeza, R. E. L., & Ingvar, M. (2002) · Cognitive Brain Research · doi:10.1016/s0926-6410(02)00052-6 · Cited by 124 · see citing works
The Behavioral High-Risk Paradigm in Psychopathology
Miller, G. A. (1995) · Series in psychopathology · doi:10.1007/978-1-4612-4234-5 · Cited by 111 · see citing works
Diamond, B. J., DeLuca, J., Kim, H., & Kelley, S. M. (1997) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639708403834 · Cited by 106 · see citing works
Bromocriptine in rheumatic and autoimmune diseases
McMurray, R. W. (2001) · Seminars in Arthritis and Rheumatism · doi:10.1053/sarh.2001.25482 · Cited by 100 · see citing works
Guillem, F., Rougier, A., & Claverie, B. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563526 · Cited by 100 · see citing works
Cognitive impairments in multiple sclerosis: A review
Sousa, D., Albert, R. H., & Kálmán, B. (2002) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750201700104 · Cited by 96 · see citing works
Guillem, F., N’Kaoua, B., Rougier, A., & Claverie, B. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb01221.x · Cited by 95 · see citing works
Neuropsychological deficits in multiple sclerosis after acute relapse
Foong, J., Rozewicz, L., Quaghebeur, G., Thompson, A. J., Miller, D. H., & Ron, M. A. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.4.529 · Cited by 92 · see citing works
Functional Magnetic Resonance Imaging
Binder, J. R. (1997) · Neurosurgery Clinics of North America · doi:10.1016/s1042-3680(18)30311-5 · Cited by 81 · see citing works
Working memory impairment among persons with chronic progressive multiple sclerosis
Grigsby, J., Ayarbe, S. D., Kravcisin, N., & Busenbark, D. (1993) · Journal of Neurology · doi:10.1007/bf00868338 · Cited by 79 · see citing works
Monk, C. S. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00384-0 · Cited by 74 · see citing works
The Neurobiological Basis of Time Estimation and Temporal Order
Lalonde, R., & Hannequin, D. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.2.151 · Cited by 69 · see citing works
Linking structural, metabolic and functional changes in multiple sclerosis
Filippi, M. (2001) · European Journal of Neurology · doi:10.1046/j.1468-1331.2001.00210.x · Cited by 51 · see citing works
Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test
Papageorgiou, C., Liappas, I., Asvestas, P., Vasios, C., Matsopoulos, G. K., Nikolaou, C., Nikita, K. S., Uzunoglu, N., & Rabavilas, A. (2001) · Neuroreport · doi:10.1097/00001756-200106130-00051 · Cited by 31 · see citing works
Honig's model of working memory and brain activation: an fMRI study
Landrø, N. I., Rund, B. R., Lund, A., Sundet, K., Mjellem, N., Asbjørnsen, A., Thomsen, T., Ersland, L., Lundervold, A., Smievoll, A. I., et al. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00038 · Cited by 30 · see citing works
The Effect of Decreased Catecholamine Transmission on ERP Indices of Selective Attention
Shelley, A. M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00190-x · Cited by 28 · see citing works
Smolnik, R., Perras, B., Mölle, M., et al. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200008000-00009 · Cited by 21 · see citing works
Glassman, R. B. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00096-2 · Cited by 20 · see citing works
The Behavioral High-Risk Paradigm in the Mood Disorders
Klein, D. N., & Anderson, R. L. (1995) · Series in psychopathology · doi:10.1007/978-1-4612-4234-5_7 · Cited by 10 · see citing works
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- Sfagos, Papageorgiou, Kosma, et al www.jnnp.com on July 12, 2023 by guest. Protected by copyright. http://jnnp.bmj.com/ J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.74.9.1231 on 21 August 2003. Downloaded from REFERENCES
- Miyake A, Shah P. Models of working memory. New York: Cambridge University Press, 1999.
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Papageorgiou, C. C., Sfagos, C., Kosma, K. K., Kontoangelos, K. A., Triantafyllou, N., Vassilopoulos, D., Rabavilas, A. D., & Soldatos, C. R. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.07.005 · Cited by 8 · see citing works
Self-citationChmiel, J., & Kładna, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15155994
- Authors
- Sfagos, C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Sfagos, C
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2003-09-01
- Volume
- 74
- Issue
- 9
- Pages
- 1231-1235
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1738660
- OpenAlex
- W2137649333
- Cited by
- 28
- References
- 43
- Citations by year
- 2023: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2012: 3
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace - NTUA (National Technical University of Athens) (submittedVersion, other-oa)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- multiple sclerosis, working memory deficits, P600, auditory event-related potentials, digit span, cognitive impairment, basal ganglia, cingulate cortex, target detection
- MeSH terms
- Adult, Cognition Disorders, Evoked Potentials, Auditory, Female, Frontal Lobe, Humans, Male, Memory Disorders, Mental Processes, Middle Aged, Multiple Sclerosis, Reaction Time
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