Cited by 58Systemic Lupus Erythematosus ResearchSystemic Sclerosis and Related DiseasesVasculitis and related conditions

I too, am America: a review of research on systemic lupus erythematosus in African-Americans

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Williams, Edith M, Bruner, Larisa, Adkins, Alyssa, Vrana, Caroline, Logan, Ayaba, Kamen, Diane, Oates, James C·2016·Lupus Science & Medicine

Abstract

Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that can cause significant morbidity and mortality. A large body of evidence has shown that African-Americans experience the disease more severely than other racial-ethnic groups. Relevant literature for the years 2000 to August 2015 were obtained from systematic searches of PubMed, Scopus, and the EBSCOHost platform that includes MEDLINE, CINAHL, etc. to evaluate research focused on SLE in African-Americans. Thirty-six of the 1502 articles were classified according to their level of evidence. The systematic review of the literature reported a wide range of adverse outcomes in African-American SLE patients and risk factors observed in other mono and multi-ethnic investigations. Studies limited to African-Americans with SLE identified novel methods for more precise ascertainment of risk and observed novel findings that hadn't been previously reported in African-Americans with SLE. Both environmental and genetic studies included in this review have highlighted unique African-American populations in an attempt to isolate risk attributable to African ancestry and observed increased genetic influence on overall disease in this cohort. The review also revealed emerging research in areas of quality of life, race-tailored interventions, and self-management. This review reemphasizes the importance of additional studies to better elucidate the natural history of SLE in African-Americans and optimize therapeutic strategies for those who are identified as being at high risk.

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  • Differences in ethnicity between the SARD-BDB and Toronto cohorts may impact results such as incidence, prevalence, and mortality rates.

    “Such differences between two groups of patients may also impact results such as the incidence, prevalence and mortality rates (76–79).”

    From Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA (2019) · cites this paper as [77]

    The Introduction (page unavailable) reports racial and ethnic variation in SLE incidence, prevalence, and mortality, supporting the possibility that ethnic composition could affect those results. The review does not examine the SARD-BDB or Toronto cohorts, and its evidence concerns SLE rather than SARDs generally. (LLM, conf=0.83)

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Authors
Williams, E. M., Bruner, L., Adkins, A., Vrana, C., Logan, A., Kamen, D., & Oates, J. C.
Affiliations
  • Medical University of South Carolina (US)
  • University of South Carolina (US)
  • Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
  • Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina, USA
Corresponding author
Williams, Edith M
Venue
Lupus Science & Medicine
Publisher
BMJ
Published
2016-08
Volume
3
Issue
1
Pages
e000144
ISSN
2053-8790 (ISSN-L)
OpenAlex
W2510748208
Cited by
58
References
126
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 5
FWCI
0.85
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Lupus Science & Medicine (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (K01AR060026)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
Keywords
systemic lupus erythematosus, African Americans, racial disparities, autoimmune disease, disease severity, risk factors, genetic susceptibility, African ancestry, environmental risk factors, quality of life, self-management, natural history (disease)

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