Retroviral vectors
Open accessAbstract
Traditionally, the retrovirus is regarded as an enemy to be overcome. However, for the past two decades retroviruses have been harnessed as vehicles for transferring genes into eukaryotic cells, a process known as transduction. During this time, the technology has moved from being a scientific laboratory tool to a potential clinical molecular medicine to be used in gene therapy. This review explains the strategy for harnessing the retrovirus life cycle, the scientific research and clinical applications of this methodology, and its limitations, as well as possible future developments.
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The 5 main classes of viral vectors can be categorized in 2 groups according to whether their genomes integrate into host cellular chromatin (oncoretroviruses and LV) or persist in the cell nucleus predominantly as extrachromosomal episomes (AAV, AV, and herpes viruses).
“The 5 main classes of viral vectors can be categorized in 2 groups according to whether their genomes integrate into host cellular chromatin (oncoretroviruses and LV) or persist in the cell nucleus predominantly as extrachromosomal episomes (AAV, AV, and herpes viruses).”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [30]
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Cites
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- Authors
- Kurian, K. M.
- Affiliations
- Western General Hospital (GB)
- Corresponding author
- Kurian, K M
- ORCID
- Kurian, K M
- Venue
- Molecular Pathology
- Publisher
- BMJ
- Published
- 2000-08-01
- Volume
- 53
- Issue
- 4
- Pages
- 173-176
- ISSN
- 1366-8714 (ISSN-L)
- PMC
- PMC1186965
- OpenAlex
- W4242380573
- Cited by
- 53
- References
- 21
- Citations by year
- 2025: 4 · 2024: 5 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 2
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
- Keywords
- retroviral vectors, gene transduction, gene therapy
- MeSH terms
- Genetic Vectors, Humans, Neoplasms, Retroviridae, Genetic Therapy, Gene Transfer Techniques
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