Use of non-steroidal anti-inflammatory drugs in US adults: changes over time and by demographic
Open accessAbstract
Objective: Aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) are preventive against cardiovascular disease (CVD) and several cancer types, but long-term use has been associated with significant health risks, resulting in conflicting recommendations on NSAID use for prevention of CVD and cancer. Previous research indicates that aspirin use increases with age and CVD risk factors and that a large percentage of the US population regularly use analgesics, including NSAIDs, but there has not been a recent, in-depth assessment of NSAID use prevalence, changes in use over time or predictors of NSAID use in the USA. Methods: We used the cross-sectional, National Health And Nutrition Examination Survey (NHANES) from 1988 to 1994 and three continuous cycles (1999–2004) to assess regular NSAID use prevalence, changes over time and predictors of regular NSAID use. Results: Overall, regular NSAID use increased over time and varied by demographic features. Participants over 60 years of age, women, participants with high body mass index, increased waist circumference or heart disease were significantly more likely to be regular NSAID users. By contrast, non-Hispanic African American and Mexican American participants were significantly less likely to regularly use NSAIDs. Conclusions: This study uses a nationally representative data set (NHANES) to provide an exploration of regular NSAID use patterns over time, highlighting several demographic, lifestyle and clinical conditions associated with regular NSAID use. Understanding who is likely to regularly use NSAIDs enables more targeted messaging both for increasing the preventive benefits and for limiting the toxicities associated with regular use of NSAIDs.
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A study in over 600 adolescents reported an association between high WBC counts and short self-reported sleep duration (<8 h/night).
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
“Given that a large proportion of the population uses NSAIDs on a regular basis (135), future research may address the long-term effects on sleep physiology.”
Background
- Authors
- Davis, J. S., Lee, H. Y., Kim, J., Advani, S. M., Peng, H.-L., Banfield, E., Hawk, E. T., Chang, S., & Frazier-Wood, A. C.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA
- Department of Biostatistics, The University of Texas School of Public Health, Houston, Texas, USA
- Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, Houston, Texas, USA
- Corresponding author
- Davis, Jennifer S
- Venue
- Open Heart
- Publisher
- BMJ
- Published
- 2017-04
- Volume
- 4
- Issue
- 1
- Pages
- e000550
- ISSN
- 2053-3624 (ISSN-L)
- PMC
- PMC5471872
- OpenAlex
- W2608303186
- Cited by
- 144
- References
- 52
- Citations by year
- 2026: 2 · 2025: 23 · 2024: 20 · 2023: 17 · 2022: 17 · 2021: 21 · 2020: 21 · 2019: 15 · 2018: 7
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Open Heart (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- USDA/ARS Children’s Nutrition Research Center, at Baylor College of Medicine
- American Heart Association
- University of Texas MD Anderson Cancer Center Duncan Family Institute for Cancer Prevention and Risk Assessment
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- nonsteroidal anti-inflammatory drugs, aspirin, drug use trends, cardiovascular disease prevention, cancer prevention, analgesic use, racial and ethnic disparities, body mass index, heart disease, older adults, women
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