The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Tuberculosis of the central nervous system
Open accessAbstract
Summary: Tuberculous involvement of the brain and spinal cord are common neurological disorders in developing countries and have recently shown a resurgence in developed ones. Tuberculous meningitis is an important manifestation and is associated with high morbidity and mortality. Diagnosis is based on clinical features, cerebrospinal fluid changes, and imaging characteristics. Bacteriological confirmation is not possible in all cases as serological tests do not have sufficient sensitivity and specificity. The polymerase chain reaction shows promise for the future. Appropriate chemotherapeutic agents should be administered as early as possible, although there is no unanimity concerning chemotherapeutic regimens or optimal duration of treatment. The patient's clinical stage at presentation is the most important prognostic factor. The role of corticosteroids is controversial but they should be administered to all patients presenting in stage III. Surgical procedures are directed at management of the hydrocephalus. Focal lesions, intracranial tuberculomas, and tuberculous abscesses, are usually located in cerebral or cerebellar hemispheres, uncommonly in brainstem and very rarely in spinal cord. They do not usually require surgical intervention and respond well to antituberculous treatment, along with corticosteroids.
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Cites
Global Epidemiology of Tuberculosis: Morbidity and Mortality of a Worldwide Epidemic
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Tuberculous Meningitis in Patients Infected with the Human Immunodeficiency Virus
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Schoeman, J. F., Van Zyl, L. E., Laubscher, J. A., & Donald, P. R. (1997) · Pediatrics · doi:10.1542/peds.99.2.226 · Cited by 300
Kennedy, D. H. (1979) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1979.03290290032021 · Cited by 294
Tuberculosis and human immunodeficiency virus infection in developing countries
Harries, A. D. (1990) · The Lancet · doi:10.1016/0140-6736(90)90216-r · Cited by 268
PATHOLOGY AND PATHOGENETIC MECHANISMS IN NEUROTUBERCULOSIS
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MR IMAGING OF CENTRAL NERVOUS SYSTEM TUBERCULOSIS
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Tuberculous meningitis in patients with and without human immunodeficiency virus infection
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Cited by
Miller, J. M., Binnicker, M. J., Campbell, S., Carroll, K. C., Chapin, K. C., Gilligan, P. H., Gonzalez, M. D., Jerris, R. C., Kehl, S. C., Patel, R., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy381 · Cited by 641
Baron, E. J., Miller, J. M., Weinstein, M. P., Richter, S. S., Gilligan, P. H., Thomson, R. B., Bourbeau, P., Carroll, K. C., Kehl, S. C., Dunne, W. M., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit278 · Cited by 592
Tuberculous meningitis: more questions, still too few answers
Thwaites, G. E., van Toorn, R., & Schoeman, J. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70168-6 · Cited by 482
Improving the Bacteriological Diagnosis of Tuberculous Meningitis
Thwaites, G. E., Chau, T. T. H., & Farrar, J. J. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.1.378-379.2004 · Cited by 288
Evaluation of GeneXpert MTB/RIF for Diagnosis of Tuberculous Meningitis
Nhu, N. T. Q., Heemskerk, D., Thu, D. D. A., Chau, T. T. H., Mai, N. T. H., Nghia, H. D. T., Loc, P. P., Ha, D. T. M., Merson, L., Thinh, T. T. V., et al. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01834-13 · Cited by 244
Metadata
- Authors
- Garg, R. K.
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-01
- Volume
- 75
- Issue
- 881
- Pages
- 133-140
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- OpenAlex
- W2016353926
- Cited by
- 306
- References
- 28
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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