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Widal agglutination test − 100 years later: still plagued by controversy
Open accessAbstract
Summary: We review the significance of the Widal agglutination test in the diagnosis of typhoid fever. Over 100 years since its introduction as a serologic means of detecting the presence of typhoid fever, the Widal test continues to be plagued with controversies involving the quality of the antigens used and interpretation of the result, particularly in endemic areas. Areas of concern with clinical and laboratory significance discussed in this review include: the techniques of test performance, interpretation of results, limitation of the value of the test results in endemic typhoid areas, the quality of the antigens used, and alternative diagnostic tests.
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Citations
Cited by
Crump, J. A., Sjölund-Karlsson, M., Gordon, M. A., & Parry, C. M. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-15 · Cited by 1,156
Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence
Gunn, J. S., Marshall, J. M., Baker, S., Dongol, S., Charles, R. C., & Ryan, E. T. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.06.007 · Cited by 321
Typhoid and paratyphoid fever in travellers
Connor, B. A., & Schwartz, E. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70239-5 · Cited by 275
Salmonella infections: An update on epidemiology, management, and prevention
Sánchez-Vargas, F. M., Abu-El-Haija, M. A., & Gómez-Duarte, O. G. (2011) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2011.11.001 · Cited by 264
Typhoid epidemiology, diagnostics and the human challenge model
Darton, T. C., Blohmke, C. J., & Pollard, A. J. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000021 · Cited by 53
Metadata
- Authors
- Olopoenia, L. A., & King, A. L.
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-02-01
- Volume
- 76
- Issue
- 892
- Pages
- 80-84
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- OpenAlex
- W1938682682
- Cited by
- 262
- References
- 0
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Olopoenia, L. A., & King, A. L. (2000). Widal agglutination test − 100 years later: still plagued by controversy. Postgraduate Medical Journal. https://doi.org/10.1136/pmj.76.892.80
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
