The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Iodine deficiency as a cause of brain damage
Open accessAbstract
This editorial reviews the impact of iodine deficiency (1) on thyroid function in pregnant women and neonates and (2) on the neurointellectual development of infants and children. All degrees of iodine deficiency (mild: iodine intake of 50–99 μg/day, moderate: 20–49 μg/day, and severe: <20 μg/day) affect thyroid function of the mother and the neonate as well as the mental development of the child. The damage increases with the degree of the deficiency, with overt endemic cretinism as the severest consequence. Maternal hypothyroxinaemia during early pregnancy is a key factor in the development of the neurological damage in the cretin. Selenium deficiency combined with iodine deficiency partly prevents the neurological damage but precipitates severe hypothyroidism in cretins. Iodine deficiency results in a global loss of 10–15 IQ points at a population level and constitutes the world’s greatest single cause of preventable brain damage and mental retardation.
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Cites
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Self-citationIODINE DEFICIENCY DISORDERS (IDD) AND THEIR ERADICATION
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Cited by
Maternal thyroid hormones early in pregnancy and fetal brain development
Escobar, G. M. D., Obregón, M. J., & Rey, F. E. D. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.03.012 · Cited by 585
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Hynes, K. L., Otahal, P., Hay, I., & Burgess, J. R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4249 · Cited by 296
Evolution of ligands, receptors and metabolizing enzymes of thyroid signaling
Holzer, G., Roux, N., & Laudet, V. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.03.021 · Cited by 62
Maternal micronutrient disturbance as risks of offspring metabolic syndrome
Shi, Y., Zhong, H., & Pang, L. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127097 · Cited by 10
Metadata
- Authors
- Delange, F.
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-04-01
- Volume
- 77
- Issue
- 906
- Pages
- 217-220
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- OpenAlex
- W2041889235
- Cited by
- 317
- References
- 34
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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