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Cited by 474

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny

Open access
Lavado-Autric, Rosalía, Ausó, Eva, García-Velasco, José Victor, del Carmen Arufe, María, Escobar del Rey, Francisco, Berbel, Pere, Morreale de Escobar, Gabriella·2003·Journal of Clinical Investigation
DOI 10.1172/jci16262
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Abstract

Epidemiological studies from both iodine-sufficient and -deficient human populations strongly suggest that early maternal hypothyroxinemia (i.e., low circulating free thyroxine before onset of fetal thyroid function at midgestation) increases the risk of neurodevelopmental deficits of the fetus, whether or not the mother is clinically hypothyroid. Rat dams on a low iodine intake are hypothyroxinemic without being clinically hypothyroid because, as occurs in pregnant women, their circulating 3,5,3'-triiodothyronine level is usually normal. We studied cell migration and cytoarchitecture in the somatosensory cortex and hippocampus of the 40-day-old progeny of the iodine-deficient dams and found a significant proportion of cells at locations that were aberrant or inappropriate with respect to their birth date. Most of these cells were neurons, as assessed by single- and double-label immunostaining. The cytoarchitecture of the somatosensory cortex and hippocampus was also affected, layering was blurred, and, in the cortex, normal barrels were not formed. We believe that this is the first direct evidence of an alteration in fetal brain histogenesis and cytoarchitecture that could only be related to early maternal hypothyroxinemia. This condition may be 150-200 times more common than congenital hypothyroidism and ought to be prevented both by mass screening of free thyroxine in early pregnancy and by early iodine supplementation to avoid iodine deficiency, however mild.

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Metadata

Authors
Lavado-Autric, R., Ausó, E., García-Velasco, J. V., del Carmen Arufe, M., Escobar del Rey, F., Berbel, P., & Morreale de Escobar, G.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2003-04-01
Volume
111
Issue
7
Pages
1073-1082
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci16262
OpenAlex
W4240837091
Cited by
474
References
43
FWCI
15.47
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. https://app.cochat.ai/papers/10.1172/jci16262
The paper
Lavado-Autric, R., Ausó, E., García-Velasco, J. V., del Carmen Arufe, M., Escobar del Rey, F., Berbel, P., & Morreale de Escobar, G. (2003). Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. Journal of Clinical Investigation. https://doi.org/10.1172/jci16262

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.