The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
Open accessAbstract
BACKGROUND: Bone-marrow derived mesenchymal stem cells (MSCs) reduce the severity of evolving acute lung injury (ALI), but their ability to repair the injured lung is not clear. A study was undertaken to determine the potential for MSCs to enhance repair after ventilator-induced lung injury (VILI) and elucidate the mechanisms underlying these effects. METHODS: Anaesthetised rats underwent injurious ventilation which produced severe ALI. Following recovery, they were given an intravenous injection of MSCs (2×10(6) cells) or vehicle immediately and a second dose 24 h later. The extent of recovery following VILI was assessed after 48 h. Subsequent experiments examined the potential for non-stem cells and for the MSC secretome to enhance VILI repair. The contribution of specific MSC-secreted mediators was then examined in a wound healing model. RESULTS: MSC therapy enhanced repair following VILI. MSCs enhanced restoration of systemic oxygenation and lung compliance, reduced total lung water, decreased lung inflammation and histological lung injury and restored lung structure. They attenuated alveolar tumour necrosis factor α concentrations while increasing concentrations of interleukin 10. These effects were not seen with non-stem cells (ie, rat fibroblasts). MSC-secreted products also enhanced lung repair and attenuated the inflammatory response following VILI. The beneficial effect of the MSC secretome on repair of pulmonary epithelial wounds was attenuated by prior depletion of keratinocyte growth factor. CONCLUSION: MSC therapy enhances lung repair following VILI via a paracrine mechanism that may be keratinocyte growth factor-dependent.
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Cites
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Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
Prockop, D. J. (1997) · Science · doi:10.1126/science.276.5309.71 · Cited by 4,629
Human mesenchymal stem cells modulate allogeneic immune cell responses
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Németh, K., Leelahavanichkul, A., Yuen, P. S. T., Mayer, B., Parmelee, A., Doi, K., Robey, P. G., Leelahavanichkul, K., Koller, B. H., Brown, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1905 · Cited by 2,364
Human mesenchymal stem cells modulate B-cell functions
Corcione, A., Benvenuto, F., Ferretti, E., Giunti, D., Cappiello, V., Cazzanti, F., Risso, M., Gualandi, F., Mancardi, G. L., Pistoia, V., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2657 · Cited by 1,767
Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
Wu, Y., Chen, L., Scott, P. G., & Tredget, E. E. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0226 · Cited by 1,676
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Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells
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Cited by
Islam, M. N., Das, S. R., Emin, M. T., Wei, M., Sun, L., Westphalen, K., Rowlands, D. J., Quadri, S. K., Bhattacharya, S., & Bhattacharya, J. (2012) · Nature Medicine · doi:10.1038/nm.2736 · Cited by 1,585
Jackson, M. V., Morrison, T. J., Doherty, D. F., McAuley, D. F., Matthay, M. A., Kissenpfennig, A., O'Kane, C. M., & Krasnodembskaya, A. D. (2016) · Stem Cells · doi:10.1002/stem.2372 · Cited by 582
Lung Extracellular Matrix and Fibroblast Function
White, E. S. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201406-240mg · Cited by 231
MSC-NTF (NurOwn®) exosomes: a novel therapeutic modality in the mouse LPS-induced ARDS model
Kaspi, H., Semo, J., Abramov, N., Dekel, C., Lindborg, S., Kern, R., Lebovits, C., & Aricha, R. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02143-w · Cited by 68
Metadata
- Authors
- Curley, G. F., Hayes, M., Ansari, B., Shaw, G., Ryan, A., Barry, F., O'Brien, T., O'Toole, D., & Laffey, J. G.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2011-11-21
- Volume
- 67
- Issue
- 6
- Pages
- 496-501
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- OpenAlex
- W2155254073
- Cited by
- 284
- References
- 26
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Curley, G. F., Hayes, M., Ansari, B., Shaw, G., Ryan, A., Barry, F., O'Brien, T., O'Toole, D., & Laffey, J. G. (2012). Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax. https://doi.org/10.1136/thoraxjnl-2011-201059
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