Clinical and functional differences between early-onset and late-onset adult asthma: a population-based tasmanian longitudinal health study
Open accessAbstract
Background Differences between early-onset and late-onset adult asthma have not been comprehensively described using prospective data. Aims To characterise the differences between early-onset and late-onset asthma in a longitudinal cohort study. Methods The Tasmanian Longitudinal Health Study (TAHS) is a population-based cohort. Respiratory histories and spirometry were first performed in 1968 when participants were aged 7 (n=8583). The cohort was traced and resurveyed from 2002 to 2005 (n=5729 responses) and a sample, enriched for asthma and bronchitis participated in a clinical study when aged 44 (n=1389). Results Of the entire TAHS cohort, 7.7% (95% CI 6.6% to 9.0%) had early-onset and 7.8% (95% CI 6.4% to 9.4%) late-onset asthma. Atopy and family history were more common in early-onset asthma while female gender, current smoking and low socioeconomic status were more common in late-onset asthma. The impact on lung function of early-onset asthma was significantly greater than for late-onset asthma (mean difference prebronchodilator (BD) FEV1/FVC −2.8% predicted (−5.3 to −0.3); post-BD FEV1FVC −2.6% predicted (−5.0 to −0.1)). However, asthma severity and asthma score did not significantly differ between groups. An interaction between asthma and smoking was identified and found to be associated with greater fixed airflow obstruction in adults with late-onset asthma. This interaction was not evident in adults with early-onset disease. Conclusions Early-onset and late-onset adult asthma are equally prevalent in the middle-aged population. Major phenotypic differences occur with asthma age-of-onset; while both share similar clinical manifestations, the impact on adult lung function of early-onset asthma is greater than for late-onset asthma.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both early and late onset adult current asthma were associated with a reduction in lung function and an increased risk of fixed airflow obstruction at 45 years.
“It has been shown that both early and late onset adult current asthma were associated with a reduction in lung function and an increased risk of fixed airflow obstruction at 45 years, with the effect of early onset asthma being greater than late onset asthma (165–167).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [166]
The effect of early onset asthma on reduction in lung function and fixed airflow obstruction at 45 years was greater than late onset asthma.
“It has been shown that both early and late onset adult current asthma were associated with a reduction in lung function and an increased risk of fixed airflow obstruction at 45 years, with the effect of early onset asthma being greater than late onset asthma (165–167).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [166]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Miller, M. R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., Crapo, R., Enright, P., van der Grinten, C. P. M., Gustafsson, P., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00034805 · Cited by 15,627 · see citing works
Spirometric Reference Values from a Sample of the General U.S. Population
Hankinson, J., Odencrantz, J. R., & Fedan, K. B. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.1.9712108 · Cited by 4,220 · see citing works
Global strategy for asthma management and prevention: GINA executive summary
Bateman, E. D., Hurd, S. S., Barnes, P. J., Bousquet, J., Drazen, J. M., FitzGerald, M., Gibson, P., Ohta, K., O'Byrne, P., Pedersen, S. E., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00138707 · Cited by 3,203 · see citing works
Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program
Moore, W. C., Meyers, D. A., Wenzel, S. E., Teague, W. G., Li, H., Li, X., D'Agostino, R., Castro, M., Curran‐Everett, D., Fitzpatrick, A. M., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200906-0896oc · Cited by 2,131 · see citing works
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
Moffatt, M. F., Gut, I. G., Démenais, F., Strachan, D. P., Bouzigon, E., Heath, S. C., von Mutius, E., Farrall, M., Lathrop, M. G., & Cookson, W. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906312 · Cited by 2,003 · see citing works
Cluster analysis and clinical asthma phenotypes
Haldar, P., Pavord, I. D., Shaw, D. E., Berry, M. A., Thomas, M., Brightling, C. E., Wardlaw, A. J., & Green, R. H. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200711-1754oc · Cited by 1,987 · see citing works
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
Moffatt, M. F., Kabesch, M., Liang, L., Dixon, A. L., Strachan, D. P., Heath, S. C., Depner, M., Berg, A. V., Bufe, A., Rietschel, E., et al. (2007) · Nature · doi:10.1038/nature06014 · Cited by 1,590 · see citing works
(1996) · European Respiratory Journal · doi:10.1183/09031936.96.09040687 · Cited by 1,002 · see citing works
The overlap syndrome of asthma and COPD: what are its features and how important is it?
Gibson, P. G., & Simpson, J. L. (2009) · Thorax · doi:10.1136/thx.2008.108027 · Cited by 607 · see citing works
Self-citationDistinguishing severe asthma phenotypes
Miranda, C., Busacker, A. A., Balzar, S., Trudeau, J. B., & Wenzel, S. E. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.10.041 · Cited by 586 · see citing works
Impact of gender on asthma in childhood and adolescence: a GA 2 LEN review
Almqvist, C., Worm, M., Leynaert, B., & for the working group of GALEN WP 2.5 ‘Gender’ (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01524.x · Cited by 563 · see citing works
The Asthma–COPD Overlap Syndrome
Postma, D. S., & Rabe, K. F. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1411863 · Cited by 561 · see citing works
Steinke, J. W., & Borish, L. (2001) · Respiratory Research · doi:10.1186/rr40 · Cited by 445 · see citing works
Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma
Bouzigon, E., Corda, E., Aschard, H., Dizier, M., Boland, A., Bousquet, J., Chateigner, N., Gormand, F., Just, J., Moual, N. L., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806604 · Cited by 395 · see citing works
Gibson, P. G., McDonald, V. M., & Marks, G. B. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61087-2 · Cited by 395 · see citing works
Smoking and asthma: dangerous liaisons
Polosa, R., & Thomson, N. C. (2012) · European Respiratory Journal · doi:10.1183/09031936.00073312 · Cited by 371 · see citing works
Underdiagnosis and Undertreatment of Asthma in the Elderly
Enright, P., Clelland, R. L. M., Newman, A. B., Gottlieb, D. J., & Lebowitz, M. D. (1999) · CHEST Journal · doi:10.1378/chest.116.3.603 · Cited by 330 · see citing works
Consensus Document on the Overlap Phenotype COPD–Asthma in COPD
Soler‐Cataluña, J. J., Cosío, B. G., Alonso, J. L. I., López-Campos, J. L., Marín, J. M., Agüero, R., Baloira, A., Carrizo, S. J., Esteban, C., Gáldiz, J. B., et al. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2012.06.017 · Cited by 264 · see citing works
Documento de consenso sobre el fenotipo mixto EPOC-asma en la EPOC
Soler‐Cataluña, J. J., Cosío, B. G., Alonso, J. L. I., López-Campos, J. L., Marín, J. M., Agüero, R., Baloira, A., Carrizo, S. J., Esteban, C., Gáldiz, J. B., et al. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2011.12.009 · Cited by 237 · see citing works
Basagaña, X., Sunyer, J., Kogevinas, M., Zock, J., Duran‐Tauleria, E., Jarvis, D., Burney, P., & Anto, J. M. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh186 · Cited by 197 · see citing works
Holguín, F., COMHAIR, S. A. A., Hazen, S. L., Powers, R. W., Khatri, S. S., Bleecker, E. R., Busse, W. W., Calhoun, W. J., Castro, M., Fitzpatrick, A. M., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201207-1270oc · Cited by 166 · see citing works
Lung function, respiratory symptoms, and the menopausal transition
Real, F. G., Svanes, C., Omenaas, E. R., Antó, J. M., Plana, E., Jarvis, D., Janson, C., Neukirch, F., Zemp, E., Dratva, J., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.08.057 · Cited by 147 · see citing works
Perret, J. L., Dharmage, S. C., Matheson, M. C., Johns, D. P., Gurrin, L. C., Burgess, J. A., Marrone, J., Markos, J., Morrison, S., Feather, I., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201205-0788oc · Cited by 128 · see citing works
Self-citationTan, D. J., Walters, E. H., Perret, J. L., Lodge, C. J., Lowe, A. J., Matheson, M. C., & Dharmage, S. C. (2015) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2015.1000311 · Cited by 112 · see citing works
Self-citationFamily History and the Risk of Early-Onset Persistent, Early-Onset Transient, and Late-Onset Asthma
London, S. J., Gauderman, W. J., Avol, E. L., Rappaport, E. B., & Peters, J. M. (2001) · Epidemiology · doi:10.1097/00001648-200109000-00019 · Cited by 111 · see citing works
Postmenopausal hormone therapy and asthma onset in the E3N cohort
Romieu, I., Fabre, A., Fournier, A., Kauffmann, F., Varraso, R., Mesrine, S., Leynaert, B., & Clavel‐Chapelon, F. (2010) · Thorax · doi:10.1136/thx.2009.116079 · Cited by 103 · see citing works
Ventilatory Function in British Adults After Asthma or Wheezing Illness at Ages 0-35
Strachan, D. P., Griffiths, J. M., Johnston, I. D., & ANDERSON, H. R. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.6.8970346 · Cited by 83 · see citing works
Changes in indoor allergen and fungal levels predict changes in asthma activity among young adults
Matheson, M. C., Abramson, M. J., Dharmage, S. C., Forbes, A. B., Raven, J. M., Thien, F. C. K., & Walters, E. H. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02272.x · Cited by 77 · see citing works
Self-citationGIBSON, H. B., SILVERSTONE, H., Gandevia, B., & Hall, G. J. L. (1969) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1969.tb105698.x · Cited by 71 · see citing works
Parity and decreased use of oral contraceptives as predictors of asthma in young women
Jenkins, M. A., Dharmage, S. C., Flander, L. B., et al. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02475.x · Cited by 70 · see citing works
Self-citationTime to define the disorders of the syndrome of COPD
Beasley, R. W., Weatherall, M. W., Travers, J., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61541-5 · Cited by 50 · see citing works
Bias in retrospective studies of trends in asthma incidence
Brøgger, J. C., Eagan, T., Eide, G. E., et al. (2004) · European Respiratory Journal · doi:10.1183/09031936.03.00041103 · Cited by 46 · see citing works
RESPIRATORY SYMPTOMS IN TASMANIAN ADOLESCENTS: A FOLLOW UP OF THE 1961 BIRTH COHORT
Giles, G. G., Lickiss, N., GIBSON, H. B., et al. (1984) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1984.tb05015.x · Cited by 44 · see citing works
Self-citationWho remembers whether they had asthma as children?
Burgess, J. A., Walters, E. H., Byrnes, G. B., Wharton, C., Jenkins, M. A., Abramson, M. J., Hopper, J. L., & Dharmage, S. C. (2006) · Journal of Asthma · doi:10.1080/02770900601028587 · Cited by 37 · see citing works
Self-citationThe Prevalence of Asthma and Respiratory Symptoms Among Young Adults: Is It Increasing in Australia?
Abramson, M. J., Kutin, J. J., Czarny, D., et al. (1996) · Journal of Asthma · doi:10.3109/02770909609054551 · Cited by 36 · see citing works
Self-citationAge of onset and the characteristics of asthma
Jeng‐Yuan, H. S. U., King, S. I., Kuo, B. I.-T., & Chiang, C. (2004) · Respirology · doi:10.1111/j.1440-1843.2004.00572.x · Cited by 30 · see citing works
Ségala, C., Priol, G., Soussan, D., et al. (2000) · Allergy · doi:10.1034/j.1398-9995.2000.00488.x · Cited by 27 · see citing works
The independent and combined effects of lifetime smoke exposures and asthma as they relate to COPD
Perret, J. L., Walters, E. H., Abramson, M. J., McDonald, C. F., & Dharmage, S. C. (2014) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2014.905913 · Cited by 16 · see citing works
Self-citationA Comparison of the Clinical and Induced Sputum Characteristics of Early- and Late-Onset Asthma
Rossall, M., Cadden, P., Kolsum, U., et al. (2012) · Lung · doi:10.1007/s00408-012-9383-y · Cited by 13 · see citing works
Adult Serum Cytokine Concentrations and the Persistence of Asthma
Kandane‐Rathnayake, R., Tang, M. L. K., Simpson, J. A., Burgess, J. A., Mészáros, D., Feather, I. H., Southey, M. C., Schroen, C. J., Hopper, J. L., Morrison, S. C., et al. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000346910 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200 · see citing works
Self-citation
- Authors
- Tan, D. J., Walters, E. H., Perret, J. L., Burgess, J. A., Johns, D. P., Lowe, A. J., Lodge, C. J., Hayati Rezvan, P., Simpson, J. A., Morrison, S., Thompson, B. R., Thomas, P. S., Feather, I., Giles, G. G., Hopper, J. L., Abramson, M. J., Matheson, M. C., & Dharmage, S. C.
- Affiliations
- University of Tasmania (AU)
- The University of Melbourne (AU)
- The University of Queensland (AU)
- The Alfred Hospital (AU)
- UNSW Sydney (AU)
- Gold Coast Hospital (AU)
- Monash University (AU)
- Corresponding author
- Dharmage, Shyamali C
- ORCID
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2016-06-14
- Volume
- 71
- Issue
- 11
- Pages
- 981-987
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- OpenAlex
- W2424863076
- Cited by
- 69
- References
- 40
- Citations by year
- 2025: 6 · 2024: 7 · 2023: 7 · 2022: 13 · 2021: 10 · 2020: 10 · 2019: 3 · 2018: 4 · 2017: 8 · 2016: 1
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- adult asthma, early-onset asthma, late-onset asthma, age of asthma onset, lung function, airflow obstruction, smoking, atopy, family history (medicine), asthma severity, asthma phenotypes, Tasmanian Longitudinal Health Study
- MeSH terms
- Adult, Airway Obstruction, Asthma, Bronchodilator Agents, Female, Hospitalization, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Respiratory Function Tests, Risk Factors, Tasmania, Age of Onset
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
