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Cited by 288

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Autoantibodies in lung cancer: possibilities for early detection and subsequent cure

Open access
Chapman, C J, Murray, A, McElveen, J E, Sahin, U, Luxemburger, U, Tureci, O, Wiewrodt, R, Barnes, A C, Robertson, J F·2008·Thorax
DOI 10.1136/thx.2007.083592
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Abstract

BACKGROUND: People with lung cancer usually present at a late stage in the course of their disease when their chances of long-term survival are low. At present there is little to offer for early diagnosis, even in those at high risk of developing the disease. Autoantibodies have been shown to be present in the circulation of people with various forms of solid tumour before cancer-associated antigens can be detected, and these molecules can be measured up to 5 years before symptomatic disease. OBJECTIVE: To assess the potential of a panel of tumour-associated autoantibody profiles as an aid to other lung cancer screening modalities. METHODS: Plasma from normal controls (n = 50), patients with non-small cell lung cancer (n = 82) and patients with small cell lung cancer (n = 22) were investigated for the presence of autoantibodies to p53, c-myc, HER2, NY-ESO-1, CAGE, MUC1 and GBU4-5 by enzyme-linked immunosorbent assay. RESULTS: Raised levels of autoantibodies were seen to at least 1/7 antigens in 76% of all the patients with lung cancer plasma tested, and 89% of node-negative patients, with a specificity of 92%. There was no significant difference between the detection rates in the lung cancer subgroups, although more patients with squamous cell carcinomas (92%) could be identified. CONCLUSION: Measurement of an autoantibody response to one or more tumour-associated antigens in an optimised panel assay may provide a sensitive and specific blood test to aid the early detection of lung cancer.

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Metadata

Authors
Chapman, C. J., Murray, A., McElveen, J. E., Sahin, U., Luxemburger, U., Tureci, O., Wiewrodt, R., Barnes, A. C., & Robertson, J. F.
Venue
Thorax
Publisher
BMJ
Published
2008-03-01
Volume
63
Issue
3
Pages
228-233
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thx.2007.083592
OpenAlex
W2148977892
Cited by
288
References
32
FWCI
6.64
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Autoantibodies in lung cancer: possibilities for early detection and subsequent cure. https://app.cochat.ai/papers/10.1136/thx.2007.083592
The paper
Chapman, C. J., Murray, A., McElveen, J. E., Sahin, U., Luxemburger, U., Tureci, O., Wiewrodt, R., Barnes, A. C., & Robertson, J. F. (2008). Autoantibodies in lung cancer: possibilities for early detection and subsequent cure. Thorax. https://doi.org/10.1136/thx.2007.083592

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