The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Obesity and the lung: 5 {middle dot} Obesity and COPD
Open accessAbstract
Chronic obstructive pulmonary disease (COPD) and obesity are common and disabling chronic health conditions with increasing prevalence worldwide. A relationship between COPD and obesity is increasingly recognised, although the nature of this association remains unknown. This review focuses on the epidemiology of obesity in COPD and the impact of excessive fat mass on lung function, exercise capacity and prognosis. The evidence for altered adipose tissue functions in obesity--including reduced lipid storage capacity, altered expression and secretion of inflammatory factors, adipose tissue hypoxia and macrophage infiltration in adipose tissue--is also reviewed. The interrelationship between these factors and their contribution to the development of insulin resistance in obesity is considered. It is proposed that, in patients with COPD, reduced oxidative capacity and systemic hypoxia may amplify these disturbances, not only in obese patients but also in subjects with hidden loss of fat-free mass. The potential interaction between abnormal adipose tissue function, systemic inflammation and COPD may provide more insight into the pathogenesis and reversibility of systemic pathology in this disease.
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Cites
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Obesity is associated with macrophage accumulation in adipose tissue
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Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death
Gami, A. S., Witt, B. J., Howard, D. E., Erwin, P. J., Gami, L. A., Somers, V. K., & Montori, V. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.032 · Cited by 1,888
Cited by
Lim, J. U., Lee, J. H., Kim, J. S., Hwang, Y. I., Kim, T.-H., Lim, S. Y., Yoo, K. H., Jung, K.-S., Kim, Y. K., & Rhee, C. K. (2017) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s141295 · Cited by 549
Lung Function Impairment and Metabolic Syndrome
Leone, N., Courbon, D., Thomas, F., Bean, K., Jégo, B., Leynaert, B., Guize, L., & Zureik, M. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200807-1195oc · Cited by 531
Hypoxemia in patients with COPD: cause, effects, and disease progression
McNicholas, W., Kent, & Mitchell (2011) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s10611 · Cited by 434
Obesity and weight management in the elderly
Han, T. S., Tajar, A., & Lean, M. E. J. (2011) · British Medical Bulletin · doi:10.1093/bmb/ldr002 · Cited by 327
Ora, J., Laveneziana, P., Ofir, D., Deesomchok, A., Webb, K. A., & O'Donnell, D. E. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200904-0530oc · Cited by 139
Self-citation
Metadata
- Authors
- Franssen, F. M. E., O'Donnell, D. E., Goossens, G. H., Blaak, E. E., & Schols, A. M. W. J.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2008-05-20
- Volume
- 63
- Issue
- 12
- Pages
- 1110-1117
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2130905430
- Cited by
- 302
- References
- 24
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Franssen, F. M. E., O'Donnell, D. E., Goossens, G. H., Blaak, E. E., & Schols, A. M. W. J. (2008). Obesity and the lung: 5 {middle dot} Obesity and COPD. Thorax. https://doi.org/10.1136/thx.2007.086827
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
