Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death
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Objectives The purpose of this research was to assess the association between the metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of longitudinal studies.Background Controversy exists regarding the cardiovascular risk associated with MetSyn.Methods We searched electronic reference databases through March 2005, studies that referenced Reaven's seminal article, abstracts presented at meetings in 2003 to 2004, and queried experts. Two reviewers independently assessed eligibility. Longitudinal studies reporting associations between MetSyn and cardiovascular events or mortality were eligible. Two reviewers independently used a standardized form to collect data from published reports. Authors were contacted. Study quality was assessed by the control of selection, detection, and attrition biases.Results We found 37 eligible studies that included 43 cohorts (inception 1971 to 1997) and 172,573 individuals. Random effects meta-analyses showed MetSyn had a relative risk (RR) of cardiovascular events and death of 1.78 (95% confidence interval [CI] 1.58 to 2.00). The association was stronger in women (RR 2.63 vs. 1.98, p = 0.09), in studies enrolling lower risk (<10%) individuals (RR 1.96 vs. 1.43, p = 0.04), and in studies using factor analysis or the World Health Organization definition (RR 2.68 and 2.06 vs. 1.67 for National Cholesterol Education Program definition and 1.35 for other definitions; p = 0.005). The association remained after adjusting for traditional cardiovascular risk factors (RR 1.54, 95% CI 1.32 to 1.79).Conclusions The best available evidence suggests that people with MetSyn are at increased risk of cardiovascular events. These results can help clinicians counsel patients to consider lifestyle interventions, and should fuel research of other preventive interventions.
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MetS is a clinical entity associated with an increased risk of ASCVD or death, even after controlling for its component risk factors (risk ratio: 1.54; 95% confidence interval: 1.32 to 1.79).
“It is imperative to recognize that MetS is not just a repackaging of its individual risk components, but, as demonstrated in at least 1 analysis, is a clinical entity associated with an increased risk of ASCVD or death, even after controlling for its component risk factors (risk ratio: 1.54; 95% confidence interval: 1.32 to 1.79) (39).”
From The CardioMetabolic Health Alliance (2015) · cites this paper as [39]
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Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
A Coefficient of Agreement for Nominal Scales
Cohen, J. (1960) · Educational and Psychological Measurement · doi:10.1177/001316446002000104 · Cited by 42,398 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099 · see citing works
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works
The file drawer problem and tolerance for null results.
Rosenthal, R. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.3.638 · Cited by 9,068 · see citing works
The combination of estimates from different experiments
Cochran, W. G. (1954) · Biometrics · doi:10.2307/3001666 · Cited by 5,380 · see citing works
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033 · see citing works
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801 · see citing works
Funnel plots for detecting bias in meta-analysis
Sterne, J. A. C., & Egger, M. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00377-8 · Cited by 3,779 · see citing works
Interaction revisited: the difference between two estimates.
Altman, D. G., & Bland, J. M. (2003) · BMJ · doi:10.1136/bmj.326.7382.219 · Cited by 3,203 · see citing works
The Metabolic Syndrome: Time for a Critical Appraisal
Kahn, R., Buse, J. B., Ferrannini, E., & Stern, M. P. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2289 · Cited by 2,377 · see citing works
Ridker, P. M., Buring, J. E., Cook, N. R., & Rifai, N. (2003) · Circulation · doi:10.1161/01.cir.0000055014.62083.05 · Cited by 2,292 · see citing works
Sackett, D. L. (1979) · Journal of Chronic Diseases · doi:10.1016/0021-9681(79)90012-2 · Cited by 2,075 · see citing works
Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., L'Italien, G. J., Pio, J. R., & Williams, G. R. (2004) · Circulation · doi:10.1161/01.cir.0000140677.20606.0e · Cited by 1,845 · see citing works
Sattar, N., Gaw, A., Scherbakova, O., Ford, I., O’Reilly, D. S. J., Haffner, S. M., Isles, C., Macfarlane, P. W., Packard, C. J., Cobbe, S. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000080897.52664.94 · Cited by 1,506 · see citing works
Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults
Ford, E. S., Giles, W. H., & Mokdad, A. H. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2444 · Cited by 1,488 · see citing works
Dandona, P., Aljada, A., Chaudhuri, A., Mohanty, P., & Garg, R. (2005) · Circulation · doi:10.1161/01.cir.0000158483.13093.9d · Cited by 1,263 · see citing works
Hu, G. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1066 · Cited by 1,135 · see citing works
de Ferranti, S. D., Gauvreau, K., Ludwig, D. S., Neufeld, E. J., Newburger, J. W., & Rifai, N. (2004) · Circulation · doi:10.1161/01.cir.0000145117.40114.c7 · Cited by 1,123 · see citing works
McNeill, A. M., Rosamond, W. D., Girman, C. J., Golden, S. H., Schmidt, M. I., East, H. E., Ballantyne, C. M., & HEISS, G. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.385 · Cited by 1,051 · see citing works
Stern, M. P., Williams, K., González-Villalpando, C., Hunt, K. J., & Haffner, S. M. (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2676 · Cited by 735 · see citing works
Clustering of metabolic factors and coronary heart disease
Wilson, P. W. F., Kannel, W. B., Silbershatz, H., & D'Agostino, R. B. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.10.1104 · Cited by 712 · see citing works
Rutter, M. K., Meigs, J. B., Sullivan, L. M., D’Agostino, R. B., & Wilson, P. W. F. (2004) · Circulation · doi:10.1161/01.cir.0000136581.59584.0e · Cited by 664 · see citing works
Hunt, K. J., Resendez, R. G., Williams, K., Haffner, S. M., & Stern, M. P. (2004) · Circulation · doi:10.1161/01.cir.0000140762.04598.f9 · Cited by 662 · see citing works
The obesity epidemic, metabolic syndrome and future prevention strategies
James, P. T., Rigby, N., Leach, R., & International Obesity Task Force (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000114707.27531.48 · Cited by 570 · see citing works
Brand, J. L. (1997) · Digital Commons - Andrews University (Andrews University) · Cited by 535 · see citing works
Girman, C. J., Rhodes, T., Mercuri, M. F., Pyörälà, K., KJEKSHUS, J. K., Pedersen, T. R., Beere, P. A., Gotto, A. M., & Clearfield, M. B. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.028 · Cited by 525 · see citing works
Meta-analysis: State-of-the-Science
Dickersin, K., & Berlin, J. A. (1992) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036084 · Cited by 502 · see citing works
Ford, E. S. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.12.022 · Cited by 501 · see citing works
Components of the Metabolic Syndrome and Risk of Cardiovascular Disease and Diabetes in Beaver Dam
Klein, R., Klein, R., & Lee, K. E. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1790 · Cited by 468 · see citing works
Resnick, H. E., Jones, K. L., Ruotolo, G., Jain, A. K., Henderson, J. A., Lu, W., & Howard, B. V. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.861 · Cited by 427 · see citing works
Katzmarzyk, P. T., Church, T. S., & Blair, S. N. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1092 · Cited by 408 · see citing works
Syndrome X and Mortality: A Population-based Study
Trevisan, M., Liu, J., Bahsas, F. B., & Menotti, A. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009572 · Cited by 389 · see citing works
Metabolic Syndrome, Obesity, and Mortality
Katzmarzyk, P. T., Church, T. S., Janssen, I., Ross, R., & Blair, S. N. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.391 · Cited by 378 · see citing works
Prognostic value of the metabolic syndrome in essential hypertension
Schillaci, G., Pirro, M., Vaudo, G., Gemelli, F., Marchesi, S., Porcellati, C., & Mannarino, E. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.12.049 · Cited by 352 · see citing works
Pyörälä, M., Miettinen, H., Halonen, P. M., Laakso, M., & Pyörälà, K. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.538 · Cited by 349 · see citing works
Onat, A., Ceyhan, K., Başar, O., Erer, B., Toprak, S., & Sansoy, V. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00236-8 · Cited by 349 · see citing works
Carotid Atherosclerosis and Coronary Heart Disease in the Metabolic Syndrome
Bonora, E., Kiechl, S. J., Willeit, J., Oberhollenzer, F., Egger, G., Bonadonna, R. C., & Muggeo, M. (2003) · Diabetes Care · doi:10.2337/diacare.26.4.1251 · Cited by 332 · see citing works
Holvoet, P., Kritchevsky, S. B., Tracy, R. P., Mertens, A. C., Rubin, S. M., Butler, J., Goodpaster, B. H., & Harris, T. B. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1068 · Cited by 318 · see citing works
Insulin Resistance Syndrome Predicts Coronary Heart Disease Events in Elderly Nondiabetic Men
Lempiäinen, P., Mykkänen, L., Pyörälä, K., Laakso, M., & Kuusisto, J. (1999) · Circulation · doi:10.1161/01.cir.100.2.123 · Cited by 293 · see citing works
Bonora, E., Targher, G., Formentini, G., Calcaterra, F., Lombardi, S., Marini, F., Zenari, L., Saggiani, F., Poli, M., Perbellini, S., et al. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.01068.x · Cited by 286 · see citing works
Consensus Development Conference on Insulin Resistance: 5–6 November 1997
American Diabetes Association (1998) · Diabetes Care · doi:10.2337/diacare.21.2.310 · Cited by 251 · see citing works
Marroquin, O. C., Kip, K. E., Kelley, D. E., Johnson, B. D., Shaw, L. J., Bairey Merz, C. N., Sharaf, B. L., Pepine, C. J., Sopko, G., & Reis, S. E. (2004) · Circulation · doi:10.1161/01.cir.0000115517.26897.a7 · Cited by 243 · see citing works
Metabolic Syndrome as a Predictor of All-Cause and Cardiovascular Mortality in Type 2 Diabetes
Bruno, G., Merletti, F., Biggeri, A., Bargero, G., Ferrero, S., Runzo, C., Cerai, S. P., Pagano, G., & Cavallo‐Perin, P. (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2689 · Cited by 224 · see citing works
Lehto, S., Rönnemaa, T., Pyörälà, K., & Laakso, M. (2000) · Diabetologia · doi:10.1007/s001250050023 · Cited by 192 · see citing works
Invited commentary: benefits of heterogeneity in meta-analysis of data from epidemiologic studies
Berlin, J. A. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117645 · Cited by 191 · see citing works
Pisciotta, L., Hamilton‐Craig, I. R., Tarugi, P., Bellocchio, A., Fasano, T., Alessandrini, P., Bon, G. B., Siepi, D., Mannarino, E., Cattin, L., et al. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.11.009 · Cited by 69 · see citing works
Nakanishi, N., Takatorige, T., Fukuda, H., Shirai, K., Li, W., Okamoto, M., Yoshida, H., Matsuo, Y., Suzuki, K., & Tatara, K. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.10.001 · Cited by 65 · see citing works
Anderson, J. L., Horne, B. D., Jones, H. U., Reyna, S. P., Carlquist, J. F., Bair, T. L., Pearson, R. R., LAPPE, D. L., & Muhlestein, J. B. (2004) · Cardiology · doi:10.1159/000076695 · Cited by 64 · see citing works
The Triglyceride Issue Revisited
Tenkanen, L. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420230107012 · Cited by 56 · see citing works
Influencia del síndrome metabólico en el riesgo cardiovascular de pacientes con diabetes tipo 2
Orna, J. A. G., Arnal, L. M. L., Herguedas, E. M., Juliani, B. B., & Córdoba, D. P. P. (2004) · Revista Española de Cardiología · doi:10.1016/s0300-8932(04)77141-9 · Cited by 54 · see citing works
How deadly is the “deadly quartet”?
Sprecher, D. L., & Pearce, G. L. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00867-6 · Cited by 49 · see citing works
Hsia, J., Bittner, V., Tripputi, M., & Howard, B. V. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00227-8 · Cited by 43 · see citing works
Cook, R. J., & Farewell, V. T. (1995) · Canadian Journal of Statistics · doi:10.2307/3315378 · Cited by 43 · see citing works
Corsetti, J. P., Zaręba, W., Moss, A. J., & Sparks, C. E. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.07.019 · Cited by 43 · see citing works
Kaukua, J., Turpeinen, A., Uusitupa, M. I. J., & NISKANEN, L. K. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00093.x · Cited by 40 · see citing works
The metabolic syndrome—is one global definition possible?
Jørgensen, M. E., & Borch‐Johnsen, K. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01400.x · Cited by 24 · see citing works
Metabolic Syndrome as a Cardiovascular Risk Factor in Patients With Type 2 Diabetes
Orna, J. A. G., Arnal, L. M. L., Herguedas, E. M., Juliani, B. B., & Córdoba, D. P. P. (2004) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(06)60626-9 · Cited by 23 · see citing works
Godsland, I. F., Bruce, R., Jeffs, J. A. R., Leyva, F., Walton, C., & Stevenson, J. C. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.05.008 · Cited by 18 · see citing works
Metabolic Syndrome: A Definition in Progress
Lim, H. S., Patel, J. V., & Lip, G. Y. H. (2004) · Circulation · doi:10.1161/01.cir.0000139383.19636.d6 · Cited by 12 · see citing works
Alberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7
Flagged first, then by citations
Research works printed but not linked: 1
- Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observa- tional studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) Group. JAMA 2000;283:2008 -12.
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596 · see citing works
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works
Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., de Ferranti, S., Faiella-Tommasino, J., Forman, D. E., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000625 · Cited by 6,185 · see citing works
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
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Mottillo, S., Filion, K. B., Genest, J., Joseph, L., Pilote, L., Poirier, P., Rinfret, S., Schiffrin, E. L., & Eisenberg, M. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.05.034 · Cited by 3,009 · see citing works
Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., de Ferranti, S., Faiella-Tommasino, J., Forman, D. E., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.003 · Cited by 2,691 · see citing works
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583 · see citing works
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162 · see citing works
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease
Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.010 · Cited by 1,896 · see citing works
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914 · see citing works
Metabolic syndrome: definitions and controversies
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Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
Després, J.-P., Lemieux, I., Bergeron, J., Pibarot, P., Mathieu, P., Larose, E., Rodés-Cabau, J., Bertrand, O. F., & Poirier, P. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.159228 · Cited by 1,589 · see citing works
Grundy, S. M. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151092 · Cited by 1,571 · see citing works
Vancampfort, D., Stubbs, B., Mitchell, A. J., De Hert, M., Wampers, M., Ward, P. B., Rosenbaum, S., & Correll, C. U. (2015) · World Psychiatry · doi:10.1002/wps.20252 · Cited by 1,271 · see citing works
Mitchell, A. J., Vancampfort, D., Sweers, K., van Winkel, R., Yu, W., & Binder, M. D. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr148 · Cited by 1,087 · see citing works
Assessing Adiposity: A Scientific Statement From the American Heart Association
Cornier, M.-A., Després, J.-P., Davis, N., Grossniklaus, D. A., Klein, S., Lamarche, B., Lopez-Jimenez, F., Rao, G., St-Onge, M.-P., Towfighi, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318233bc6a · Cited by 945 · see citing works
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 919 · see citing works
Jacobson, T. A., Ito, M. K., Maki, K. C., Orringer, C. E., Bays, H. E., Jones, P. H., McKenney, J. M., Grundy, S. M., Gill, E. A., Wild, R. A., et al. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.02.003 · Cited by 772 · see citing works
Psychological Perspectives on Pathways Linking Socioeconomic Status and Physical Health
Matthews, K., & Gallo, L. C. (2011) · Annual Review of Psychology · doi:10.1146/annurev.psych.031809.130711 · Cited by 682 · see citing works
Pre-Diabetes, Metabolic Syndrome, and Cardiovascular Risk
Grundy, S. M. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.080 · Cited by 627 · see citing works
Metabolic Syndrome and Incident Diabetes
Ford, E. S., Li, C., & Sattar, N. A. (2008) · Diabetes Care · doi:10.2337/dc08-0423 · Cited by 575 · see citing works
Cardiovascular consequences of metabolic syndrome
Tune, J. D., Goodwill, A. G., Sassoon, D., & Mather, K. J. (2017) · Translational research · doi:10.1016/j.trsl.2017.01.001 · Cited by 618 · see citing works
Metabolic Syndrome and Kidney Disease: A Systematic Review and Meta-analysis
Thomas, G., Sehgal, A. R., Kashyap, S. R., Srinivas, T. R., Kirwan, J. P., & Navaneethan, S. D. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02180311 · Cited by 553 · see citing works
Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., Groshen, S., Mack, W. J., Guen, E., Di Biase, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8700 · Cited by 553 · see citing works
Welzel, T. M., Graubard, B. I., Zeuzem, S., El‐Serag, H. B., Davila, J. A., & McGlynn, K. A. (2011) · Hepatology · doi:10.1002/hep.24397 · Cited by 539 · see citing works
Association of Sedentary Behaviour with Metabolic Syndrome: A Meta-Analysis
Edwardson, C. L., Gorely, T., Davies, M. J., Gray, L. J., Khunti, K., Wilmot, E. G., Yates, T. E., & Biddle, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034916 · Cited by 539 · see citing works
Meta-analysis: Its strengths and limitations
WALKER, E., HERNANDEZ, A. V., & KATTAN, M. W. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.6.431 · Cited by 519 · see citing works
Zicari, S., Sessa, L., Cotugno, N., Ruggiero, A., Rocchi, F., Concato, C., Rocca, S., Zangari, P., Manno, E. C., & Palma, P. (2019) · Viruses · doi:10.3390/v11030200 · Cited by 525 · see citing works
Elmets, C. A., Leonardi, C. L., Davis, D. M. R., Gelfand, J. M., Lichten, J. B., Mehta, N. N., Armstrong, A. W., Connor, C. J., Cordoro, K. M., Elewski, B. E., et al. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.11.058 · Cited by 506 · see citing works
Animal models of nonalcoholic fatty liver disease
Hebbard, L., & George, J. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.191 · Cited by 495 · see citing works
Sattar, N. A., McConnachie, A., Shaper, A. G., Blauw, G. J., Buckley, B. M., de Craen, A. J. M., Ford, I., Forouhi, N. G., Freeman, D. J., Jukema, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60602-9 · Cited by 492 · see citing works
Salas-Salvadó, J., Fernández-Ballart, J., Ros, E., Martínez-González, M.-A., Fitó, M., Estruch, R., Corella, D., Fiol, M., Gómez-Gracia, E., Arós, F., et al. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.22.2449 · Cited by 463 · see citing works
Neeland, I. J., Lim, S., Tchernof, A., Gastaldelli, A., Rangaswami, J., Ndumele, C. E., Powell-Wiley, T. M., & Després, J.-P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00563-5 · Cited by 463 · see citing works
Review: Mortality trends in the general population: the importance of cardiorespiratory fitness
Lee, D.-C., Artero, E. G., Sui, X., & Blair, S. N. (2010) · Journal of Psychopharmacology · doi:10.1177/1359786810382057 · Cited by 628 · see citing works
Psoriasis and metabolic syndrome: A systematic review and meta-analysis of observational studies
Armstrong, A. W., Harskamp, C. T., & Armstrong, E. J. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.08.015 · Cited by 458 · see citing works
Hepatic insulin resistance, metabolic syndrome and cardiovascular disease
Meshkani, R., & Adeli, K. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.05.018 · Cited by 458 · see citing works
Gallo, L., Penedo, F., Monteros, K. E. D. L., & Arguelles, W. (2009) · Journal of Personality · doi:10.1111/j.1467-6494.2009.00598.x · Cited by 454 · see citing works
Golden, S. H., Brown, A., Cauley, J. A., Chin, M. H., Gary-Webb, T. L., Kim, C., Sosa, J. A., Sumner, A. E., & Anton, B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2043 · Cited by 405 · see citing works
The role of leptin/adiponectin ratio in metabolic syndrome and diabetes
López-Jaramillo, P., Gómez-Arbeláez, D., López-López, J., López-López, C., Martínez-Ortega, J., Gómez-Rodríguez, A., & Triana-Cubillos, S. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0053 · Cited by 405 · see citing works
Metabolic syndrome across Europe: Different clusters of risk factors
Scuteri, A., Laurent, S., Cucca, F., Cockcroft, J., Cunha, P., Rodríguez‐Mañas, L., Mattace-Raso, F. U. S., Muiesan, M. L., Ryliškytė, L., Rietzschel, E. R., et al. (2014) · European Journal of Preventive Cardiology · doi:10.1177/2047487314525529 · Cited by 391 · see citing works
Antipsychotic-associated weight gain: management strategies and impact on treatment adherence
Dayabandara, M., Hanwella, R., Ratnatunga, S. S., Seneviratne, S., Suraweera, C. U., & de Silva, V. A. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s113099 · Cited by 377 · see citing works
Anxiety and new onset of cardiovascular disease: critical review and meta-analysis
Batelaan, N. M., Seldenrijk, A., Bot, M., van Balkom, A. J. L. M., & Penninx, B. W. J. H. (2016) · British Journal of Psychiatry · doi:10.1192/bjp.bp.114.156554 · Cited by 362 · see citing works
Grundy, S. M. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.10.001 · Cited by 349 · see citing works
Grundy, S. M., Arai, H., Barter, P. J., Bersot, T. P., Betteridge, D. J., Carmena, R., Cuevas, A. M., Davidson, M. H., Genest, J. J., Kesäniemi, Y. A., et al. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.12.005 · Cited by 328 · see citing works
Simon, T. G., Roelstraete, B., Hagström, H., Sundström, J., & Ludvigsson, J. F. (2021) · Gut · doi:10.1136/gutjnl-2021-325724 · Cited by 331 · see citing works
Vancampfort, D., Correll, C. U., Wampers, M., Sienaert, P., Mitchell, A. J., De Herdt, A., Probst, M., Scheewe, T. W., & De Hert, M. (2014) · Psychological Medicine · doi:10.1017/s0033291713002778 · Cited by 317 · see citing works
Vancampfort, D., Wampers, M., Mitchell, A. J., Correll, C. U., Herdt, A. D., Probst, M., & Binder, M. D. (2013) · World Psychiatry · doi:10.1002/wps.20069 · Cited by 320 · see citing works
Guembe, M. J., Fernandez-Lazaro, C. I., Sayón-Orea, C., Toledo, E., Moreno‐Iribas, C., for the RIVANA Study Investigators, Cosials, J. B., Reyero, J. B., Dı́ez, J., Diego, P. G., et al. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01166-6 · Cited by 331 · see citing works
Insulin resistance is a cardiovascular risk factor in humans
Adeva‐Andany, M. M., Martínez‐Rodríguez, J., González-Lucán, M., Fernández‐Fernández, C., & Castro-Quintela, E. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.02.023 · Cited by 314 · see citing works
Metabolic Syndrome: Past, Present and Future
Lemieux, I., & Despres, J. (2020) · Nutrients · doi:10.3390/nu12113501 · Cited by 272 · see citing works
Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke
Weikert, C., Stefan, N., Schulze, M. B., Pischon, T., Berger, K., Joost, H., Häring, H., Boeing, H., & Fritsche, A. (2008) · Circulation · doi:10.1161/circulationaha.108.814418 · Cited by 310 · see citing works
Obesity and the lung: 5 {middle dot} Obesity and COPD
Franssen, F. M. E., O'Donnell, D. E., Goossens, G. H., Blaak, E. E., & Schols, A. M. W. J. (2008) · Thorax · doi:10.1136/thx.2007.086827 · Cited by 300 · see citing works
van Dijk, S. J., Feskens, E. J., Bos, M. B., Hoelen, D. W., Heijligenberg, R., Bromhaar, M. G., de Groot, L. C., de Vries, J. H., Müller, M., & Afman, L. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27792 · Cited by 291 · see citing works
The CardioMetabolic Health Alliance
Sperling, L. S., Mechanick, J. I., Neeland, I. J., Herrick, C. J., Després, J.-P., Ndumele, C. E., Vijayaraghavan, K., Handelsman, Y., Puckrein, G. A., Araneta, M. R. G., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.06.1328 · Cited by 294 · see citing works
Metabolic syndrome, or What you will: definitions and epidemiology
Day, C. (2007) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2007.003 · Cited by 285 · see citing works
Drager, L. F., Lopes, H. F., Maki‐Nunes, C., Trombetta, I. C., Toschi‐Dias, E., Alves, M. J. N. N., Fraga, R. F., Jun, J. C., Negrão, C. E., Krieger, E. M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012065 · Cited by 284 · see citing works
Rodríguez‐Monforte, M., Sánchez, E., Barrio, F., Costa, B., & Flores‐Mateo, G. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1305-y · Cited by 284 · see citing works
Pujades‐Rodríguez, M., Morgan, A. W., Cubbon, R. M., & Wu, J. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003432 · Cited by 284 · see citing works
Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome
Wang, H. H., Lee, D. K., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2020) · Pediatric Gastroenterology Hepatology & Nutrition · doi:10.5223/pghn.2020.23.3.189 · Cited by 294 · see citing works
D’Aiuto, F., Sabbah, W., Netuveli, G., Donos, N., Hingorani, A. D., Deanfield, J. E., & Tsakos, G. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2522 · Cited by 280 · see citing works
Pattyn, N., Cornelissen, V. A., Eshghi, S. R. T., & Vanhees, L. (2013) · Sports Medicine · doi:10.1007/s40279-012-0003-z · Cited by 266 · see citing works
Papadaki, A., Nolen‐Doerr, E., & Mantzoros, C. S. (2020) · Nutrients · doi:10.3390/nu12113342 · Cited by 266 · see citing works
Adherence to the Mediterranean Diet and Inflammatory Markers
Sureda, A., Bibiloni, M. D. M., Julibert, A., Bouzas, C., Argelich, E., Llompart, I., Pons, A., & Tur, J. A. (2018) · Nutrients · doi:10.3390/nu10010062 · Cited by 256 · see citing works
Prevalence of metabolic syndrome in Brazilian adults: a systematic review
Vidigal, F. D. C., Bressan, J., Babió, N., & Salas‐Salvadó, J. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-1198 · Cited by 247 · see citing works
Rosenbaum, S., Stubbs, B., Ward, P. B., Steel, Z., Lederman, O., & Vancampfort, D. (2015) · Metabolism · doi:10.1016/j.metabol.2015.04.009 · Cited by 246 · see citing works
Metabolic syndrome and liver transplantation: A review and guide to management
Watt, K. D. S., & Charlton, M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.01.040 · Cited by 243 · see citing works
Licht, C. M. M., Vreeburg, S. A., van Reedt Dortland, A. K. B., Giltay, E. J., Hoogendijk, W. J. G., DeRijk, R. H., Vogelzangs, N., Zitman, F. G., de Geus, E. J. C., & Penninx, B. W. J. H. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2801 · Cited by 240 · see citing works
Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State
Monserrat-Mesquida, M., Quetglas‐Llabrés, M. M., Capó, X., Bouzas, C., Mateos, D., Pons, A., Tur, J. A., & Sureda, A. (2020) · Antioxidants · doi:10.3390/antiox9030236 · Cited by 235 · see citing works
The metabolic syndrome in cancer survivors
de Haas, E. C., Oosting, S. F., Lefrandt, J. D., Wolffenbuttel, B. H. R., Sleijfer, D. T., & Gietema, J. A. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70287-6 · Cited by 234 · see citing works
Managing Atherosclerotic Cardiovascular Risk in Young Adults
Stone, N. J., Smith, S. C., Orringer, C. E., Rigotti, N. A., Návar, A. M., Khan, S. S., Jones, D. W., Goldberg, R. B., Mora, S., Blaha, M. J., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.016 · Cited by 250 · see citing works
Strength training versus aerobic interval training to modify risk factors of metabolic syndrome
Stensvold, D., Tjønna, A. E., Skaug, E.-A., Aspenes, S., Stølen, T., Wisløff, U., & Slørdahl, S. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00996.2009 · Cited by 231 · see citing works
Amabile, N., Cheng, S. C., Renard, J. M., Larson, M. G., Ghorbani, A., McCabe, E. L., Griffin, G. K., Guérin, C. L., Ho, J. E., Shaw, S. Y., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu153 · Cited by 231 · see citing works
Enas, E., Mohan, V., Deepa, M., Farooq, S., Pazhoor, S., & Chennikkara, H. (2007) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4564.2007.07392.x · Cited by 254 · see citing works
Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad ?
Pofi, R., Caratti, G., Ray, D. W., & Tomlinson, J. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad016 · Cited by 225 · see citing works
Casas‐Agustench, P., López-Uriarte, P. J., Bulló, M., Ros, E., Vila, J., & Salas‐Salvadó, J. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.08.005 · Cited by 211 · see citing works
Brand, J. S., Rovers, M. M., Yeap, B. B., Schneider, H. J., Tuomainen, T., Haring, R., Corona, G., Onat, A., Maggio, M. G., Bouchard, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100409 · Cited by 213 · see citing works
Alcohol consumption and risk of metabolic syndrome: A meta-analysis of prospective studies
Sun, K., Ren, M., Liu, D., Wang, C., Yang, C. H., & Yan, L. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.10.003 · Cited by 211 · see citing works
Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials
Chiva‐Blanch, G., & Badimón, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5812401 · Cited by 211 · see citing works
Wewege, M. A., Thom, J. M., Rye, K.-A., & Parmenter, B. J. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.05.002 · Cited by 210 · see citing works
Adherence to the Mediterranean diet and risk of metabolic syndrome and its components
Babió, N., Bulló, M., Basora, J., Martínez‐González, M. Á., Fernandez-Ballart, J. D., Márquez‐Sandoval, F., Molina, C., & Salas‐Salvadó, J. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.10.007 · Cited by 201 · see citing works
Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis
Wu, J. J., Kavanaugh, A., Lebwohl, M. G., Gniadecki, R., & Merola, J. F. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18044 · Cited by 214 · see citing works
Mitjavila, M. T., Fandos, M., Salas‐Salvadó, J., Covas, M., Borrego, S., Estruch, R., Lamuela-Raventós, R. M., Corella, D., Martínez‐González, M. Á., Sánchez, J. M., et al. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.002 · Cited by 200 · see citing works
Pirih, F. Q. M., Monajemzadeh, S., Singh, N., Sinacola, R. S., Shin, J. M., Chen, T., Fenno, J. C., Kamarajan, P., Rickard, A. H., Travan, S., et al. (2021) · Periodontology 2000 · doi:10.1111/prd.12379 · Cited by 200 · see citing works
Alkerwi, A., Boutsen, M., Vaillant, M., Barré, J., Lair, M., Albert, A., Guillaume, M., & Dramaix, M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.10.036 · Cited by 198 · see citing works
Rosenzweig, J. L., Ferrannini, E., Grundy, S. M., Haffner, S. M., Heine, R. J., Horton, E. S., & Kawamori, R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0222 · Cited by 194 · see citing works
Glucose Intolerance in Pregnancy and Postpartum Risk of Metabolic Syndrome in Young Women
Retnakaran, R., Qi, Y., Connelly, P. W., Sermer, M., Zinman, B., & Hanley, A. J. G. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1990 · Cited by 190 · see citing works
A Meta-Analysis of the Metabolic Syndrome Prevalence in the Global HIV-Infected Population
Nguyen, K. A., Peer, N., Mills, E. J., & Kengne, A. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150970 · Cited by 192 · see citing works
Cardiovascular Risk Factors and Incident Alzheimer Disease: A Systematic Review of the Literature
Purnell, C., Gao, S., Callahan, C. M., & Hendrie, H. C. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318187541c · Cited by 189 · see citing works
Dumas, M., Kinross, J. K., & Nicholson, J. K. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.001 · Cited by 186 · see citing works
Yang, Z., Miyahara, H., Takeo, J., & Katayama, M. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-32 · Cited by 186 · see citing works
- Authors
- Gami, A. S., Witt, B. J., Howard, D. E., Erwin, P. J., Gami, L. A., Somers, V. K., & Montori, V. M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Gami, Apoor S.
- ORCID
- Somers, Virend K.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 49
- Issue
- 4
- Pages
- 403-414
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W74340591
- Cited by
- 1,888
- References
- 67
- Citations by year
- 2026: 31 · 2025: 38 · 2024: 70 · 2023: 58 · 2022: 76 · 2021: 91 · 2020: 87 · 2019: 99 · 2018: 103 · 2017: 84 · 2016: 113 · 2015: 125 · 2014: 131 · 2013: 140 · 2012: 122
- FWCI
- 91.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- metabolic syndrome, cardiovascular events, cardiovascular mortality, cardiovascular risk, sex differences, metabolic syndrome definitions, traditional cardiovascular risk factors, lifestyle intervention
- MeSH terms
- Cardiovascular Diseases, Humans, Longitudinal Studies, Risk Factors, Metabolic Syndrome
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