Lung Function Impairment and Metabolic Syndrome
Abstract
Rationale: Increased risk for cardiovascular morbidity and mortality has been related to both lung function impairment and metabolic syndrome. Data on the relationship between lung function and metabolic syndrome are sparse. Objectives: To investigate risk for lung function impairment according to metabolic syndrome traits. Methods: This cross-sectional population-based study included 121,965 men and women examined at the Paris Investigations Préventives et Cliniques Center between 1999 and 2006. The lower limit of normal was used to define lung function impairment (FEV1 or FVC < lower limit of normal). Metabolic syndrome was assessed according to the American Heart Association/National Heart, Lung, and Blood Institute statement. Measurements and Main Results: We used a logistic regression model and principal component analysis to investigate the differential associations between lung function impairment and specific components of metabolic syndrome. Lung function impairment was associated with metabolic syndrome (prevalence = 15.0%) independently of age, sex, smoking status, alcohol consumption, educational level, body mass index, leisure-time physical activity, and cardiovascular disease history (odds ratio [OR] [95% confidence interval], 1.28 [1.20–1.37] and OR, 1.41 [1.31–1.51] for FEV1 and FVC, respectively). Three factors were identified from factor analysis: “lipids” (low high-density lipoprotein cholesterol, high triglycerides), “glucose–blood pressure” (high fasting glycemia, high blood pressure), and “abdominal obesity” (large waist circumference). All factors were inversely related to lung function, but abdominal obesity was the strongest predictor of lung function impairment (OR, 1.94 [1.80–2.09] and OR, 2.11 [1.95–2.29], for FEV1 and FVC, respectively). Similar results were obtained for women and men. Conclusions: We found a positive independent relationship between lung function impairment and metabolic syndrome in both sexes, predominantly due to abdominal obesity. Further studies are required to clarify the underlying mechanisms.
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Added weight on the thorax and abdomen (and also the neck) can significantly affect static and dynamic lung volumes along with respiratory mechanics, usually in a dose-response fashion.
“Added weight on the thorax and abdomen (and also the neck), can significantly affect static and dynamic lung volumes along with respiratory mechanics,92–112 usually in a dose-response fashion.”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [94]
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- Authors
- Leone, N., Courbon, D., Thomas, F., Bean, K., Jégo, B., Leynaert, B., Guize, L., & Zureik, M.
- Affiliations
- INSERM U700, Faculte´ de Me´decine Xavier Bichat Universite´ Denis Diderot, Paris VII, Paris, France; and
- Inserm (FR)
- Investigations Pre´ventives et Cliniques, Paris, Ile de France, Paris, France
- Sorbonne Université (FR)
- Délégation Paris 5 (FR)
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03
- Volume
- 179
- Issue
- 6
- Pages
- 509-516
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2102828736
- Cited by
- 531
- References
- 4
- Citations by year
- 2026: 12 · 2025: 31 · 2024: 44 · 2023: 30 · 2022: 30 · 2021: 43 · 2020: 25 · 2019: 33 · 2018: 27 · 2017: 30 · 2016: 23 · 2015: 29 · 2014: 30 · 2013: 34 · 2012: 31
- FWCI
- 30.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- lung function impairment, metabolic syndrome, abdominal obesity, waist circumference, FEV1, FVC, cardiovascular risk, dyslipidemia, hypertriglyceridemia, low HDL cholesterol, hyperglycemia, hypertension, sex differences
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Blood Glucose, Blood Pressure, Cross-Sectional Studies, Female, Forced Expiratory Volume, Humans, Cholesterol, LDL, Male, Middle Aged, Obesity, Sex Factors, Triglycerides, Vital Capacity, Logistic Models, Metabolic Syndrome, Principal Component Analysis, Waist Circumference, Young Adult
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