Nocturnal intermittent hypoxia and C reactive protein among middle-aged community residents: a cross-sectional survey
Open accessAbstract
BACKGROUND: There are conflicting results for the association between obstructive sleep apnoea and raised C reactive protein (CRP) levels. A study was undertaken to investigate whether nocturnal intermittent hypoxia, a surrogate marker for obstructive sleep apnoea, was associated with CRP levels among a community-dwelling Japanese population. METHODS: Among participants in the Circulatory Risk in Communities Study (CIRCS), 1422 male and 2466 female community residents aged 40-69 years were tested during sleep. No nocturnal intermittent hypoxia, mild nocturnal intermittent hypoxia and moderate to severe nocturnal intermittent hypoxia were defined using 3% oxygen desaturation index cut-off points at 5 and 15 events/h, respectively. High-sensitivity CRP levels were measured using a latex particle-enhanced immunonephelometric assay. Multivariate analysis was adjusted for age, sex, body mass index, smoking status, current alcohol intake, hypertension, hypercholesterolaemia, diabetes mellitus and menopausal status for women. RESULTS: Multivariable-adjusted mean CRP levels among men were 0.70 mg/l (95% CI 0.65 to 0.75) for no nocturnal intermittent hypoxia, 0.82 mg/l (95% CI 0.74 to 0.89) for mild nocturnal intermittent hypoxia and 0.84 mg/l (95% CI 0.70 to 1.00) for moderate to severe nocturnal intermittent hypoxia (p for trend=0.03). The values for women were 0.59 mg/l (95% CI 0.57 to 0.62), 0.66 mg/l (95% CI 0.59 to 0.73) and 0.82 mg/l (95% CI 0.62 to 1.03), respectively (p for trend=0.008). Compared with no nocturnal intermittent hypoxia, the prevalence of a high CRP level (>or=1.0 mg/l) was 1.4-1.7-fold higher for mild to severe nocturnal intermittent hypoxia in both sexes. CONCLUSIONS: Nocturnal intermittent hypoxia is associated with raised serum CRP levels among middle-aged Japanese subjects.
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More hypoxemia as measured by T90 and lower SaO2 nadir in those with similar AHI is associated with more inflammation (measured by C-reactive protein, platelet count, and endothelial stiffness).
“It has been shown that more hypoxemia as measured by T90 and lower SaO2 nadir in those with similar AHI is associated with more inflammation (measured by C-reactive protein [CRP], platelet count, and endothelial stiffness).28–30”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [29]
The Discussion reports an association between nocturnal intermittent hypoxia, measured by 3% oxygen desaturation index, and higher hs-CRP in middle-aged community residents. The paper does not establish the claimed association using T90 or SaO2 nadir among people with similar AHI, and it does not report platelet count or endothelial stiffness as inflammation outcomes. Page numbers were not available in our copy. (LLM, conf=0.88)
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- Authors
- Muraki, I., Tanigawa, T., Yamagishi, K., Sakurai, S., Ohira, T., Imano, H., Kitamura, A., Kiyama, M., Sato, S., Shimamoto, T., Konishi, M., Iso, H., & for the CIRCS Investigators
- Affiliations
- The University of Osaka (JP)
- Ehime University (JP)
- University of Tsukuba (JP)
- Chiba Prefectural Institute of Public Health (JP)
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2010-06-01
- Volume
- 65
- Issue
- 6
- Pages
- 523-527
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2153448165
- Semantic Scholar
- 8ab0d121a41e265c2deca84cb179bfc488159e37
- Cited by
- 30
- References
- 33
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- University of Tsukuba
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- C-reactive protein, obstructive sleep apnea, inflammation, middle-aged adults, community-dwelling population, Japanese population, Circulatory Risk in Communities Study, oxygen desaturation index
- MeSH terms
- Adult, Aged, Hypoxia, C-Reactive Protein, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Biomarkers, Confounding Factors, Epidemiologic, Sleep Apnea, Obstructive, Atherosclerosis
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