Correlates of Serum C-Reactive Protein (CRP) — No Association With Sleep Duration or Sleep Disordered Breathing
Open accessAbstract
STUDY OBJECTIVES: Increasing evidence suggests that alterations in sleep duration are associated with cardiovascular disease (CVD) and mortality. Additionally, sleep disordered breathing (SDB), which is associated with disturbed nighttime sleep and hypoxemia, may be an independent risk factor for CVD. The inflammatory marker, C-reactive protein (CRP), is an important predictor of CVD. We investigated potential associations between circulating CRP, sleep duration, and SDB. DESIGN: Cross-sectional Study. POPULATION: Participants were 907 adults from the Wisconsin Sleep Cohort Study (WSCS). MEASUREMENTS AND RESULTS: CRP was measured after overnight polysomnography. The relationships between CRP and sleep parameters were evaluated using multiple linear regression with and without controlling for age, sex, and body mass index (BMI) and other potential confounders. CRP was found to be higher for women and had a strong positive correlation with age and BMI. CRP showed a significant positive association with current smoking, waist-hip ratio (WHR), LDL-cholesterol, triglycerides, leptin, and insulin, independent of age, sex, and BMI. Significant independent negative associations for CRP were observed with HDL-cholesterol (HDL), insulin sensitivity (quantitative insulin sensitivity check index [QUICKI]), and hours of exercise. There was a significant positive association between CRP levels and the apnea-hypopnea index (AHI, the measure of SDB), but these relationships were not significant after adjustment for age, sex, and BMI. No significant association between CRP levels and measures of sleep duration (polysomnographic and self-reported) were found. CONCLUSION: There was no significant association between CRP levels and sleep duration. The lack of an independent association between CRP levels and SDB suggests that the reported relationship between these 2 variables may be primarily driven by their association with obesity.
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Several high-quality studies found no relationship between self-reported and objective short sleep duration and markers of inflammation.
“Several high-quality studies have found no relationship between self-reported and objective (ie, polysomnographic) short sleep duration and markers of inflammation (Larkin et al, 2005;Taheri et al, 2007;Marsland et al, 2008;Lee et al, 2009;Rief et al, 2010;Ramey et al, 2012)”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Taheri et al, 2007
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- Authors
- Taheri, S., Austin, D., Lin, L., Nieto, F. J., Young, T., & Mignot, E.
- Affiliations
- University of Bristol (GB)
- University of Wisconsin–Madison (US)
- Howard Hughes Medical Institute (US)
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08
- Volume
- 30
- Issue
- 8
- Pages
- 991-996
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC1978379
- OpenAlex
- W1571999185
- Cited by
- 189
- References
- 46
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 11 · 2017: 7 · 2016: 11 · 2015: 16 · 2014: 15 · 2013: 21 · 2012: 11
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- National Institute on Aging (AG14124, R01AG014124)
- National Heart, Lung, and Blood Institute (R01HL062252, HL 071515, R01HL071515, HL62252)
- National Institute of Mental Health (MH-073435, R01MH073435)
- National Center for Research Resources (M01RR003186, RR03186)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- C-reactive protein, sleep duration, sleep-disordered breathing, apnea-hypopnea index, inflammation, cardiovascular risk, obesity, sex differences, insulin sensitivity, Wisconsin Sleep Cohort Study
- MeSH terms
- Adult, Blood Glucose, C-Reactive Protein, Cardiovascular Diseases, Female, Humans, Insulin, Life Style, Male, Risk Factors, Sleep Apnea Syndromes, Smoking, Statistics as Topic, Cohort Studies, Body Mass Index, Polysomnography, Leptin, Waist-Hip Ratio
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