CoChat
Sign Up
Cited by 1,721Chronic Obstructive Pulmonary Disease (COPD) ResearchHealth Systems, Economic Evaluations, Quality of LifeAsthma and respiratory diseases

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

A measure of quality of life for clinical trials in chronic lung disease

Open access
Guyatt, G H, Berman, L B, Townsend, M, Pugsley, S O, Chambers, L W·1987·Thorax
DOI 10.1136/thx.42.10.773PMC PMC460950
Open this paper in CoChat — free accountOpen PDF

Abstract

Since the relationships between pulmonary function, exercise capacity, and functional state or quality of life are generally weak, a self report questionnaire has been developed to determine the effect of treatment on quality of life in clinical trials. One hundred patients with chronic airflow limitation were asked how their quality of life was affected by their illness, and how important their symptoms and limitations were. The most frequent and important items were used to construct a questionnaire evaluating four dimensions: dyspnoea, fatigue, emotional function, and the patient's feeling of control over the disease (mastery). Reproducibility, tested by repeated administration to patients in a stable condition, was excellent: the coefficient of variation was less than 12% for all four dimensions. Responsiveness (sensitivity to change) was tested by administering the questionnaire to 13 patients before and after optimisation of their drug treatment and to another 28 before and after participation in a respiratory rehabilitation programme. In both cases large, statistically significant improvements in all four dimensions were noted. Changes in questionnaire score were correlated with changes in spirometric values, exercise capacity, and patients' and physicians' global ratings. Thus it has been shown that the questionnaire is precise, valid, and responsive. It can therefore serve as a useful disease specific measure of quality of life for clinical trials.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/thx.42.10.773

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Parkerson GR, Gehlback SH, Wagner EH, et al. The Duke-UNC Health Proffle. Med Care 1981;19:806-28.

Cited by

Sorted by citations

See all 1,721

Related

See all

Metadata

Authors
Guyatt, G. H., Berman, L. B., Townsend, M., Pugsley, S. O., & Chambers, L. W.
Affiliations
McMaster University (CA)
ORCID
Venue
Thorax
Publisher
BMJ
Published
1987-10-01
Volume
42
Issue
10
Pages
773-778
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thx.42.10.773
PMC
PMC460950
OpenAlex
W2097667004
Cited by
1,721
References
28
Citations by year
2026: 19 · 2025: 17 · 2024: 32 · 2023: 26 · 2022: 30 · 2021: 34 · 2020: 39 · 2019: 37 · 2018: 30 · 2017: 53 · 2016: 46 · 2015: 54 · 2014: 60 · 2013: 60 · 2012: 59
FWCI
12.15
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords
quality of life, chronic lung disease, chronic airflow obstruction, self-report questionnaire, dyspnea, fatigue, emotional functioning, reproducibility, responsiveness, pulmonary rehabilitation, spirometry, exercise capacity
MeSH terms
Clinical Trials as Topic, Humans, Lung Diseases, Obstructive, Quality of Life, Surveys and Questionnaires

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review