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Cited by 1,232

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials.

Open access
Juniper, E F, Guyatt, G H, Epstein, R S, Ferrie, P J, Jaeschke, R, Hiller, T K·1992·Thorax
DOI 10.1136/thx.47.2.76
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Abstract

BACKGROUND: In the past only physiological and clinical outcomes have been used to assess the effect of asthma interventions and the effect of the intervention on the lives of the patients has not been determined. The objective of this study was to assess health related impairment of quality of life in adult asthmatic patients and to develop a questionnaire for measuring quality of life in clinical trials in asthma. METHODS: Impairment of quality of life in adults with asthma was evaluated from structured interviews in which patients were asked to identify the parts of their daily lives affected by asthma. On the basis of these results, an asthma quality of life questionnaire was developed in an interviewer and self administered form and tested for comprehension and acceptability. A total of 150 adults with asthma and with a wide range of airway hyperresponsiveness were enrolled from previous clinical trials, local asthma clinics, and notices in the media. RESULTS: Areas of quality of life impairment included symptoms classically associated with asthma, responses to environmental stimuli, the need to avoid these stimuli, limitation of activities, and emotional dysfunction. Areas of impairment were similar across strata of airway hyperresponsiveness, age, and treatment requirements and between sexes, thus allowing a single questionnaire suitable for all adults with asthma to be developed. The questionnaire contains 32 items and takes 5-10 minutes to administer; in the pretesting it was shown to be acceptable to a wide range of patients. CONCLUSIONS: The questionnaire includes areas of quality of life impairment that are important to adult asthmatic patients. It has been designed to be responsive to within subject change and therefore may be used as a measure of outcome in clinical trials in asthma.

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Citations

Cites

Show all 1 references

Research works printed but not linked: 23

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  21. Guyatt GH, Norgradi S, Halcrow S, Singer J, Sullivan MJJ, Fallen EL. Development and testing of a new measure of health status for clinical trials in heart failure. J Gen Intern Med 1989;4:101-7. · DOI · Paper page
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Metadata

Authors
Juniper, E. F., Guyatt, G. H., Epstein, R. S., Ferrie, P. J., Jaeschke, R., & Hiller, T. K.
Venue
Thorax
Publisher
BMJ
Published
1992-02-01
Volume
47
Issue
2
Pages
76-83
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thx.47.2.76
OpenAlex
W2105665234
Cited by
1,232
References
1
FWCI
9.75
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. https://app.cochat.ai/papers/10.1136/thx.47.2.76
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Juniper, E. F., Guyatt, G. H., Epstein, R. S., Ferrie, P. J., Jaeschke, R., & Hiller, T. K. (1992). Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax. https://doi.org/10.1136/thx.47.2.76

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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