CoChat
Sign Up
Cited by 51

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Effects of metformin on apoptosis and α-synuclein in a rat model of pentylenetetrazole-induced epilepsy

Hussein, Abdelaziz M., Eldosoky, Mohamed, El-Shafey, Mohamed, El-Mesery, Mohamed, Ali, Amr N., Abbas, Khaled M., Abulseoud, Osama A.·2019·Canadian Journal of Physiology and Pharmacology
DOI 10.1139/cjpp-2018-0266
Open this paper in CoChat — free account

Abstract

The present study was designed to examine the possible neuroprotective and antiepileptic effects of metformin (Metf) in a rat model of pentylenetetrazole (PTZ)-induced epilepsy and its possible underlying mechanisms. Forty male albino rats were assigned to 4 groups of equal size: (1) normal control (NC) group, (2) Metf group: daily treatment with Metf (200 mg/kg, i.p.) for 2 weeks, (3) PTZ group: treatment with PTZ (50 mg/kg, i.p.) every other day for 2 weeks, and (4) Metf + PTZ group: daily treatment with PTZ and metformin (200 mg/kg, i.p.) for 2 weeks. Administration of PTZ caused a significant increase in seizure score and duration, induced a state of oxidative stress (high malondialdehyde, low reduced glutathione and catalase activity), and led to the upregulation of β-catenin, caspase-3, and its cleavage products, Hsp70 and α-synuclein, in hippocampal regions as well as a significant reduction in seizure latency. While Metf treatment significantly ameliorated PTZ-induced seizures, attenuated oxidative stress, and upregulated α-synuclein and β-catenin expression, it also inhibited caspase-3 activation and the release of the cleavage product and caused more upregulation in Hsp70 expression in hippocampal regions (p < 0.05). In conclusion, the antiepileptic and neuroprotective effects of Metf in PTZ-induced epilepsy might be due to the inhibition of apoptosis, attenuation of oxidative stress and α-synuclein expression, and upregulation of Hsp70.

Overview

Integrity signals

Registry

Crossref · 10.1139/cjpp-2018-0266

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Metformin induces nuclear retention of AUF1, disrupting its interaction with target mRNAs, and is neuroprotective in different Parkinson's disease models in part by decreasing SNCA levels, phosphorylation, and aggregation.

    “Coincidentally, the hypoglycemic agent metformin that induces nuclear retention of AUF1 disrupting its interaction with target mRNAs [31], is neuroprotective in different PD models in part by decreasing SNCA levels [32], phosphorylation [33,34] and aggregation [35].”

    From RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts (2023) · cites this paper as [32]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 69

  1. 10.1146/annurev-biochem-072909-095555 · DOI
  2. 10.1007/s12035-015-9091-8 · DOI
  3. 10.12669/pjms.333.11996 · DOI
  4. 10.1111/j.1528-1167.2007.01055.x · DOI
  5. 10.1016/j.bbrc.2004.05.204 · DOI
  6. 10.17305/bjbms.2017.2044 · DOI
  7. Chen Z.F., 2013, Chin. Med. J., 126, 937, 10.3760/cma.j.issn.0366-6999.20122331 · DOI
  8. Chuang Y.C., 2010, Acta Neurol. Taiwan., 19, 3
  9. 10.1016/j.cell.2012.05.012 · DOI · Paper page
  10. 10.1016/j.brainres.2013.06.043 · DOI
  11. 10.1073/pnas.0603523104 · DOI
  12. 10.1016/j.neuroscience.2013.01.050 · DOI
  13. 10.1016/j.brainres.2013.08.039 · DOI
  14. 10.1016/j.nbd.2013.11.002 · DOI
  15. Eller M., 2011, Clin. Chem. Lab. Med., 49, 403, 10.1515/CCLM.2011.077 · DOI
  16. 10.1007/s12031-007-9002-1 · DOI
  17. Engel T., 2009, Int. J. Physiol. Pathophysiol. Pharmacol., 1, 97
  18. 10.1093/jnen/61.10.903 · DOI
  19. 10.1016/S0169-328X(96)00138-6 · DOI
  20. 10.1016/0306-4522(95)92049-P · DOI
  21. 10.1016/j.neuroscience.2004.12.029 · DOI
  22. 10.1126/science.281.5381.1309 · DOI
  23. 10.1016/S0091-3057(02)01044-4 · DOI
  24. 10.1139/cjpp-2016-0219 · DOI
  25. 10.1016/j.bbrc.2011.11.073 · DOI
  26. 10.1016/S1734-1140(10)70357-1 · DOI
  27. 10.1371/journal.pone.0074420 · DOI
  28. Lee C.S., 1994, Zentralbl. Pathol., 140, 259
  29. 10.1111/j.1750-3639.2010.00414.x · DOI
  30. 10.1161/STROKEAHA.110.589697 · DOI
  31. 10.1016/j.pbb.2012.03.002 · DOI · Paper page
  32. 10.2307/3578988 · DOI
  33. 10.1586/14789450.4.2.227 · DOI
  34. 10.1016/S0006-3223(03)00700-5 · DOI
  35. 10.1007/s11011-017-0132-z · DOI
  36. 10.1016/0167-4838(96)00089-1 · DOI
  37. 10.1523/JNEUROSCI.20-09-03214.2000 · DOI
  38. 10.1186/1756-6606-2-20 · DOI
  39. Naseer M.I., 2011, Pak. J. Pharm. Sci., 24, 263
  40. 10.4049/jimmunol.0803563 · DOI
  41. National Research Council. 1996. Guide for the care and use of laboratory animals. National Academies Press, Washington, D.C.
  42. 10.1093/med/9780199746545.001.0001 · DOI
  43. 10.1111/j.1528-1167.2008.01579.x · DOI
  44. 10.1016/j.lfs.2012.08.017 · DOI
  45. 10.1016/j.parkreldis.2008.08.002 · DOI
  46. 10.1242/dmm.008110 · DOI
  47. 10.1016/0013-4694(72)90177-0 · DOI
  48. 10.14581/jer.14011 · DOI
  49. 10.1097/WNR.0000000000000751 · DOI
  50. Shehata A.M., 2011, Bull. Egypt. Soc. Physiol. Sci., 31, 135
  51. 10.1016/0306-4522(96)00326-0 · DOI
  52. 10.1371/journal.pone.0097868 · DOI
  53. 10.1038/sj.bjp.0706396 · DOI
  54. 10.1016/S0009-8981(00)00337-5 · DOI
  55. 10.1038/ncb0311-184 · DOI
  56. 10.1016/j.bbrc.2013.03.036 · DOI
  57. 10.1371/journal.pone.0074428 · DOI
  58. 10.1016/j.bbrc.2011.05.034 · DOI
  59. 10.1046/j.1365-2990.2003.00452.x · DOI
  60. 10.1016/j.stem.2012.03.016 · DOI · Paper page
  61. 10.1007/s11064-013-0980-9 · DOI
  62. Xing X.L., 2011, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 33, 659
  63. 10.1007/s00726-005-0281-y · DOI
  64. 10.1016/j.bbrc.2017.01.157 · DOI
  65. 10.1111/j.1460-9568.1996.tb01605.x · DOI
  66. 10.2174/1871527312666131223114149 · DOI
  67. 10.1016/j.bbrc.2014.04.130 · DOI
  68. Zhao Z.G., 2004, Asian J. Androl., 6, 319
  69. 10.1172/JCI13505 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Hussein, A. M., Eldosoky, M., El-Shafey, M., El-Mesery, M., Ali, A. N., Abbas, K. M., & Abulseoud, O. A.
Affiliations
  • Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Department of Human Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
  • Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Chemistry and Drug Metabolism, IRP, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, Baltimore, MD, USA.
Venue
Canadian Journal of Physiology and Pharmacology
Publisher
Canadian Science Publishing
Published
2019-01
Volume
97
Issue
1
Pages
37-46
ISSN
  • 0008-4212
  • 1205-7541
DOI
10.1139/cjpp-2018-0266
Cited by
51
References
4
Language
en
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review