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Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

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Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

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α‐Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

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DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation

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Cell Biology and Pathophysiology of α-SynucleinPreprint

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Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP

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The Synucleinopathies: Twenty Years On

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Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

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The Formation of Highly Soluble Oligomers of α-Synuclein Is Regulated by Fatty Acids and Enhanced in Parkinson's Disease

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α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

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Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

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α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

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The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

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RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

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α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

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Lipid Rafts Mediate the Synaptic Localization of α-Synuclein

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Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice

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Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

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α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis

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Structure of membrane-bound α-synuclein from site-directed spin labeling and computational refinement

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Lewy bodies

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

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Amyloid Precursor Protein, Presenilins, and α-Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer’s Disease

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Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

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Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson’s disease?

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Direct binding and functional coupling of α-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis

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Membrane-bound α-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form

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Defects in trafficking bridge Parkinson’s disease pathology and genetics

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Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior

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Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

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Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration

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Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids

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α-Synuclein and neuronal cell death

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A Structural and Functional Role for 11-mer Repeats in α-Synuclein and Other Exchangeable Lipid Binding Proteins

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α-Synuclein Overexpression in PC12 and Chromaffin Cells Impairs Catecholamine Release by Interfering with a Late Step in Exocytosis

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Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease

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Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence

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Genetic and environmental factors in the cause of Parkinson's disease

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Synucleins Are a Novel Class of Substrates for G Protein-coupled Receptor Kinases

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Striatal dopamine neurotransmission: Regulation of release and uptake

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Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

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Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

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Gene Expression in Human Alcoholism: Microarray Analysis of Frontal Cortex

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Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice

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Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

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Summary

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Manuel, J., Verdugo, G., Armanini, M. P., et al. (2013)

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

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Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

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Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

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Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synuclein

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