Maintenance of genetic variability by mutation–selection balance: a child's guide through the jungle
Abstract
Metric characters closely connected with fitness have little additive genetic variability, presumably because it is quickly exhausted under continuous directional selection on fitness. Other metric characters have substantial additive genetic variability with a typical heritability of about 0.5. A popular model is that the second class of characters is subject to weak stabilizing selection for an optimal value, which depletes genetic variability, while recurrent mutation tends to restore it. Can this model account for the variability observed, given the evidence available about the strength of selection and mutation rates? Much theoretical work has been done on this complex problem. This work is reviewed, with the intention of simplifying it as much as possible.Key words: mutation–selection balance, genetic variability, continuum-of-alleles model, house-of-cards approximation.
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The existence of disease-promoting variants reflects a balance between mutation creating new susceptibility variants and selection preventing them from drifting into the population.
“The existence of disease-promoting variants reflects the balance between mutation creating new susceptibility variants, and selection preventing them from drifting into the population2,28.”
From Rare and common variants: twenty arguments (2012) · cites this paper as [28]
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- Authors
- Bulmer, M. G.
- Corresponding author
- Bulmer, M. G.
- Venue
- Genome
- Publisher
- Canadian Science Publishing
- Published
- 1989-01-15
- Volume
- 31
- Issue
- 2
- Pages
- 761-767
- ISSN
- 0831-2796 (ISSN-L)
- 1480-3321
- OpenAlex
- W1974664068
- Cited by
- 100
- References
- 0
- Citations by year
- 2024: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 4
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genome (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Mathematics › Geometry and Topology › Morphological variations and asymmetry
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- mutation-selection balance, genetic variation, additive genetic variance, stabilizing selection, recurrent mutations, heritability, mutation rate, directional selection
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