Integrating haplotypes and single genetic variability effects of the Pax7 gene on growth traits in two cattle breeds
Abstract
The paired box 7 (Pax7) gene encoding for the transcription factor can regulate the conversion of stem cells into myogenic cells and participate in the development and regeneration of skeletal muscle. The aims of this study were to detect variations of the Pax7 gene by DNA pool sequencing and aCRS–RFLP methods in 1441 cattle from five breeds and to investigate their associations with growth traits in Nanyang and Chinese red steppe cattle. Altogether, three novel single nucleotide polymorphisms (SNPs) were identified in the last intron of the Pax7 gene: NC_007300: ss1 (g. G103688A), ss2 (g. T103735C), and ss3 (g. A103764T). Genotypes and the referring haplotype frequencies showed a high similarity trend among five breeds, and the G, T, and A allele frequencies of the three loci were always superior when separate or in combination. Association analysis of the single SNPs and haplotype combinations revealed that the T allele of ss2 and ss3 loci and the haplotype H 2 H 2(GG-TT-TT) showed significant effects on growth traits such as body height, body mass, and chest girth in cattle at early stages (6 and 12 months old) (P < 0.05). The results showed that Pax7 gene variations and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
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Human pluripotent stem cells induced to express PAX7 and treated with defined chemical cocktails yield transplantable muscle progenitors that refill the satellite cell niche and maintain dystrophin-positive fibers in dystrophin-deficient mice.
“Induced expression of PAX7 and exposure to defined chemical cocktails145–147 in human pluripotent stem cells has been shown to generate engraftable muscle progenitor cells that replenish the satellite cell compartment and sustain formation of dystrophin-positive myofibers in dystrophin-deficient mice145,147.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [145]
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Stem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works
- Authors
- Xu, Y., Zhou, Y., Wang, N., Lan, X., Zhang, C., Lei, C., & Chen, H.
- Affiliations
- Northwest A&F University (CN)
- Jiangsu Normal University (CN)
- Venue
- Genome
- Publisher
- Canadian Science Publishing
- Published
- 2013-01
- Volume
- 56
- Issue
- 1
- Pages
- 9-15
- ISSN
- 0831-2796 (ISSN-L)
- 1480-3321
- OpenAlex
- W2323681238
- Cited by
- 14
- References
- 30
- Citations by year
- 2023: 2 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2014: 2 · 2013: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genome (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- single nucleotide polymorphisms, haplotypes, cattle growth traits, Nanyang cattle, skeletal muscle development, body height, body mass, chest circumference, intronic polymorphism
- MeSH terms
- Animals, Cattle, Gene Frequency, Haplotypes, Introns, Animals, Inbred Strains, Polymorphism, Single Nucleotide, Body Size, PAX7 Transcription Factor, Genetic Association Studies
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