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Cited by 358

The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

Effects of Ageing on the Motor Unit: A Brief Review

Doherty, Timothy J., Vandervoort, Anthony A., Brown, William F.·1993·Canadian Journal of Applied Physiology
DOI 10.1139/h93-029
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Abstract

This review briefly summarizes the current state of knowledge regarding age related changes in skeletal muscle, followed by a more in-depth review of ageing effects on animal and human motor units (MUs). Ageing in humans is generally associated with reductions in muscle mass (atrophy), leading to reduced voluntary and electrically evoked contractile strength by the 7th decade for most muscle groups studied. As well, contraction and one-half relaxation times are typically prolonged in muscles of the elderly. Evidence from animal and human studies points toward age associated MU loss as the primary mechanism for muscle atrophy, and such losses may be greatest among the largest and fastest MUs. However, based on studies in animals and humans, it appears that at least some of the surviving MUs are able to partially compensate for MU losses, as indicated by an increase in the average MU size with age. The fact that muscles in the elderly have fewer, but on average larger and slower, MUs has important implications for motor control and function in this population. Key words: skeletal muscle, motor neuron, motor axon, contractile properties, adaptation

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Metadata

Authors
Doherty, T. J., Vandervoort, A. A., & Brown, W. F.
Venue
Canadian Journal of Applied Physiology
Publisher
Canadian Science Publishing
Published
1993-12-01
Volume
18
Issue
4
Pages
331-358
ISSN
1066-7814 (ISSN-L)
DOI
10.1139/h93-029
OpenAlex
W2026880027
Cited by
358
References
132
FWCI
2.00
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Effects of Ageing on the Motor Unit: A Brief Review. https://app.cochat.ai/papers/10.1139/h93-029
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Doherty, T. J., Vandervoort, A. A., & Brown, W. F. (1993). Effects of Ageing on the Motor Unit: A Brief Review. Canadian Journal of Applied Physiology. https://doi.org/10.1139/h93-029

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