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Cited by 1,135Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

Muscle strength and speed of movement in relation to age and muscle morphology

Larsson, L., Grimby, G., Karlsson, J.·1979·Journal of Applied Physiology
DOI 10.1152/jappl.1979.46.3.451
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Abstract

Maximum values for isometric strength, dynamic strength, and speed of movement (MEV) in the quadriceps muscle were measured in 114 male subjects who were between 11 and 70 yr. Biopsy samples were taken from the quadriceps muscle in 51 of the subjects (22–65 yr. old). Isometric and dynamic strength increased up to the third decade, remained almost constant to the fifth decade, and then decreased with increasing age. However, no measurable external atrophy of the quadriceps muscle, explaining the decline in strength, could be seen in old age. Histochemical changes in the muscle tissue such as decreased proportion of type II fibers and a selective atrophy of type II fibers, were seen with increasing age. The strength decline in old age was also observed to correlate significantly with the type II fiber area. Multiple regression analyses indicated, however, that mechanisms other than the type II fiber atrophy might be responsible for the decline in strength performance during aging. The implications of these findings are discussed.

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Crossref · 10.1152/jappl.1979.46.3.451

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  • There is an aging-related decline in SM-mediated metabolic function that manifests with a diminishment of mitochondrial function and capacity for thermogenic energy expenditure.

    “Furthermore, there is also an aging-related decline in SM-mediated metabolic function that manifests with a diminishment of mitochondrial function and capacity for thermogenic energy expenditure [17,33].”

    From Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management (2025) · cites this paper as [33]

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Authors
Larsson, L., Grimby, G., & Karlsson, J.
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1979-03-01
Volume
46
Issue
3
Pages
451-456
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1979.46.3.451
OpenAlex
W2135377155
Cited by
1,135
References
0
Citations by year
2026: 6 · 2025: 13 · 2024: 22 · 2023: 21 · 2022: 25 · 2021: 28 · 2020: 30 · 2019: 35 · 2018: 27 · 2017: 19 · 2016: 23 · 2015: 21 · 2014: 33 · 2013: 36 · 2012: 40
FWCI
2.59
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
muscle strength, movement speed, aging, quadriceps, muscle fiber area, isometric strength, dynamic strength, muscle morphology
MeSH terms
Adolescent, Adult, Aged, Aging, Child, Histocytochemistry, Humans, Isometric Contraction, Male, Mathematics, Middle Aged, Muscle Contraction, Muscles

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